Monitoring seasonal influenza vaccination coverage among pregnant women in the United States

Abstract Background Pertussis and seasonal influenza are responsible for significant maternal, neonatal, and infant morbidity and mortality, but vaccine coverage rates (VCR) for both pertussis (administered as a tetanus, diphtheria, acellular pertussis [Tdap] vaccination) and seasonal influenza in pregnancy remain generally low. Only a small number of countries, including Spain, the United Kingdom (UK), and the United States (US), have high Tdap and seasonal influenza VCRs in pregnancy. The purpose of this study was to identify the key factors that contributed to the high VCRs observed in these countries. Methods The experience from both Tdap and seasonal influenza vaccination programmes during pregnancy were documented in Spain, the UK, and the US using a three-step approach. A literature review yielded 157 publications, and a further 117 documents were selected through desk research. A published five-pillar VCR framework for influenza was amended to evaluate the specific contributing factors leading to high Tdap and seasonal influenza VCRs among pregnant women. Results The analysis identified components that contributed to higher VCR in pregnant women across three different healthcare systems in Spain, UK, and US. The combination of several key interventions in each country led to a rapid increase in VCR that reached near-optimal levels (i.e. 75% for seasonal influenza) within a few years. As well as inclusion in national immunisation programme and vaccine reimbursement, key components that were identified included the mobilisation of health authorities, prenatal care Healthcare Professionals (HCP) and scientific societies, the inclusion of vaccination in antenatal medical guidance, the provision of educational material to HCPs, and a strong disease awareness driven by recent pertussis outbreaks in each country. Conclusions Although there is no simple, universal solution to improving sub-optimal VCRs, the list of components identified in this study from three countries with high-performing Tdap and seasonal influenza vaccination programmes provides a basis for public health and medical stakeholders in other countries to define strategies to successfully implement national vaccination programmes for pregnant women.

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Seasonal Influenza Vaccination Coverage Among Adult Populations in the United States, 2005-2011

American Journal of Epidemiology ◽

10.1093/aje/kwt158 ◽

2013 ◽

Vol 178 (9) ◽

pp. 1478-1487 ◽

Cited By ~ 44

Author(s):

P.-J. Lu ◽

J. A. Singleton ◽

G. L. Euler ◽

W. W. Williams ◽

C. B. Bridges

Keyword(s):

United States ◽

Influenza Vaccination ◽

Vaccination Coverage ◽

Seasonal Influenza ◽

The United States ◽

Seasonal Influenza Vaccination

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Vaccination In Pregnancy Against Pertussis And Seasonal Influenza: Key Learnings And Components From High-Performing Vaccine Programmes In Three Countries: United Kingdom, The United States And Spain

10.21203/rs.3.rs-491336/v1 ◽

2021 ◽

Author(s):

Théophile Baïssas ◽

Florence Boisnard ◽

Inmaculada Cuesta Esteve ◽

Marta García Sánchez ◽

Christine E. Jones ◽

...

Keyword(s):

United States ◽

United Kingdom ◽

Influenza Vaccination ◽

Pregnant Women ◽

Seasonal Influenza ◽

The United States ◽

National Immunisation Programme ◽

Seasonal Influenza Vaccination ◽

High Performing ◽

In Pregnancy

Abstract Background: Pertussis and seasonal influenza are responsible for significant maternal, neonatal, and infant morbidity and mortality, but vaccine coverage rates (VCR) for both pertussis (administered as a tetanus, diphtheria, acellular pertussis [Tdap] vaccination) and seasonal influenza in pregnancy remain generally low. Only a small number of countries, including Spain, the United Kingdom (UK), and the United States of America (USA), have high Tdap and seasonal influenza VCRs in pregnancy. The purpose of this study was to identify the key factors that contributed to the high VCRs observed in these countries.Methods: The experience from both Tdap and seasonal influenza vaccination programmes during pregnancy were documented in Spain, the UK, and the USA using a three-step approach. A literature review yielded 157 publications, and a further 117 documents were selected through desk research. A published five-pillar VCR framework for influenza was amended to evaluate the specific contributing factors leading to high Tdap and seasonal influenza VCRs among pregnant women.Results: The analysis identified components that contributed to higher VCR in pregnant women across three different healthcare systems in Spain, UK, and USA. The combination of several key interventions in each country led to a rapid increase in VCR that reached near-optimal levels (i.e. 75% for seasonal influenza) within a few years. As well as inclusion in national immunisation programme and vaccine reimbursement, key components that were identified included the mobilisation of health authorities, prenatal care Healthcare Professionals (HCP) and scientific societies, the inclusion of vaccination in antenatal medical guidance, the provision of educational material to HCPs, and a strong disease awareness driven by recent pertussis outbreaks in each country.Conclusions: Although there is no simple, universal solution to improving sub-optimal VCRs, the list of components identified in this study from three countries with high-performing Tdap and seasonal influenza vaccination programmes provides a basis for public health and medical stakeholders in other countries to define strategies to successfully implement national vaccination programmes for pregnant women.

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Seasonal Influenza Vaccination Patterns Among Pregnant Women in New Mexico

Hispanic Health Care International ◽

10.1177/1540415319896254 ◽

2019 ◽

Vol 18 (4) ◽

pp. 214-223

Author(s):

Upasana Chalise ◽

Jill A. McDonald ◽

Anup Amatya ◽

Martha Morales

Keyword(s):

Health Care ◽

New Mexico ◽

Influenza Vaccination ◽

Pregnant Women ◽

Seasonal Influenza ◽

Vaccine Coverage ◽

The United States ◽

Vaccination Rate ◽

Seasonal Influenza Vaccination ◽

Border States

Introduction: Seasonal influenza vaccination is recommended for pregnant women, but half of the pregnant women in the United States remain unvaccinated. Vaccine coverage in U.S.–Mexico border states has not been examined in depth even though risk factors for low vaccine coverage exist in these states, especially in the counties bordering Mexico. Method: Using 2012-2014 New Mexico (NM) Pregnancy Risk Assessment and Monitoring System data, this study examined the weighted annual seasonal influenza vaccination rates and the relationship of various factors to vaccination among NM residents with a live birth during those years. Results: Among respondents, 53.8% were Hispanic, 15.7% were Native American, and 30.5% were non-Hispanic White. The vaccination rate in NM increased from 49.0% in 2012 to 64.8% in 2014. The adjusted odds of vaccination were higher among women whose health care provider recommended/offered vaccination during the year prior to delivery compared to women whose provider did not (AOR = 11.92, 95% confidence interval [CI: 9.86, 14.42]) and among those living in the U.S.–Mexico nonborder counties compared to those living in the border counties (AOR = 1.23, 95% CI [1.18, 1.25]). Conclusion: Efforts to increase the vaccination rate among pregnant women in border states should concentrate on health care providers and the highest risk women, such as those resident in the border region.

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Effect of expanded US recommendations for seasonal influenza vaccination: comparison of two pediatric emergency departments in the United States and Canada

Canadian Medical Association Journal ◽

10.1503/cmaj.110241 ◽

2011 ◽

Vol 183 (13) ◽

pp. E1025-E1032 ◽

Cited By ~ 5

Author(s):

A. G. Hoen ◽

D. L. Buckeridge ◽

K. M. L. Charland ◽

K. D. Mandl ◽

C. Quach ◽

...

Keyword(s):

United States ◽

Influenza Vaccination ◽

Emergency Departments ◽

Seasonal Influenza ◽

The United States ◽

Pediatric Emergency ◽

Seasonal Influenza Vaccination

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Seasonal influenza vaccination trends from 2007–2011 in privately insured children and adults in the United States

Vaccine ◽

10.1016/j.vaccine.2014.07.009 ◽

2014 ◽

Vol 32 (48) ◽

pp. 6563-6568 ◽

Cited By ~ 7

Author(s):

Evgeniya Antonova ◽

Christopher S. Ambrose ◽

David Kern ◽

Stan L. Block ◽

Herve Caspard ◽

...

Keyword(s):

United States ◽

Influenza Vaccination ◽

Seasonal Influenza ◽

The United States ◽

Seasonal Influenza Vaccination ◽

Privately Insured

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Faculty Opinions recommendation of Effect of expanded US recommendations for seasonal influenza vaccination: comparison of two pediatric emergency departments in the United States and Canada.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13352978.14724083 ◽

2011 ◽

Author(s):

George Petrikkos ◽

Sotirios Tsiodras

Keyword(s):

United States ◽

Influenza Vaccination ◽

Emergency Departments ◽

Seasonal Influenza ◽

The United States ◽

Pediatric Emergency ◽

Seasonal Influenza Vaccination

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2742. The Impact of Influenza Vaccination on Antibiotic Use in the United States, 2010–2017

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.2419 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S965-S966

Author(s):

Eili Klein ◽

Emily Schueller ◽

Katie K Tseng ◽

Arindam Nandi

Keyword(s):

United States ◽

Antibiotic Resistance ◽

Influenza Vaccination ◽

Vaccination Coverage ◽

Seasonal Influenza ◽

Antibiotic Use ◽

The United States ◽

Antibiotic Prescribing ◽

Coverage Rates ◽

The Impact

Abstract Background Antibiotic resistance is a cause of morbidity and mortality driven by inappropriate prescribing. In the United States, a third of all outpatient antibiotic prescriptions may be inappropriate. Seasonal influenza rates are significantly associated with antibiotic prescribing rates. The impact of influenza vaccination coverage on antibiotic prescribing is unknown. Methods We conducted a retrospective analysis of state-level vaccination coverage and antibiotic prescribing rates from 2010 to 2017. We used fixed effects regression to analyze the relationship between cumulative vaccine coverage rates for a season and the per capita number of prescriptions for systemic antibiotics for the corresponding season (January–March) controlling for temperature, poverty, healthcare infrastructure, population structure, and vaccine effectiveness. Results Rates of vaccination coverage ranged from 33% in Nevada to 52% in Rhode Island for the 2016–2017 season, while antibiotic use rates ranged from 25 prescriptions per 1,000 inhabitants in Alaska to 377 prescriptions per 1,000 inhabitants in West Virginia (Figure 1). Vaccination coverage rates were highly correlated with reduced prescribing rates, and controlling for other factors, we found that a one percent increase in the influenza vaccination rate was associated with 1.40 (95% CI: 2.22–0.57, P < 0.01) fewer antibiotic prescriptions per 1,000 inhabitants (Table 1). Increases in the vaccination coverage rate in the pediatric population (aged 0–18) had the strongest effect, followed by the elderly (aged 65+). Conclusion Vaccination can reduce morbidity and mortality from seasonal influenza. Though coverage rates are far below levels necessary to generate herd immunity, we found that higher coverage rates in a state were associated with lower antibiotic prescribing rates. While the effectiveness of the vaccine varies from year to year and the factors that drive antibiotic prescribing rates are multi-factorial, these results suggest that increased vaccination coverage for influenza would have significant benefit in terms of reducing antibiotic overuse and correspondingly antibiotic resistance. Disclosures All authors: No reported disclosures.

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