scholarly journals Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib

2006 ◽  
Vol 17 (7) ◽  
pp. 1120-1127 ◽  
Author(s):  
F. Cappuzzo ◽  
L. Toschi ◽  
G. Tallini ◽  
G.L. Ceresoli ◽  
I. Domenichini ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Insulin Like Growth Factor ◽  
Small Cell Lung ◽  
Lung Cancer Patients

Prognostic role of insulin-like growth factor receptor-1 expression in small cell lung cancer

Apmis ◽  
2009 ◽  
Vol 117 (12) ◽  
pp. 861-869 ◽  
Author(s):  
MYUNG HEE CHANG ◽  
JEEYUN LEE ◽  
JOUNGHO HAN ◽  
YEON HEE PARK ◽  
JIN SEOK AHN ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Insulin Like Growth Factor ◽  
Small Cell Lung ◽  
Prognostic Role

Prognostic role of insulin-like growth factor receptor-1 (IGFR-1) and insulin-like growth factor binding protein-3 (IGFBP-3) expression in small cell lung cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22155-e22155
Author(s):  
M. Chang ◽  
Y. Won ◽  
J. Han ◽  
H. Kim ◽  
O. Kwon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Insulin Like Growth Factor ◽  
Small Cell Lung ◽  
Extensive Disease ◽  
Igfbp 3

e22155 Background: Insulin-like growth factor receptor-1 (IGFR-1) is a cellular membrane receptor overexpressed in many tumor cell lines and in some human tumors that seems to play a critical role in anti-apoptosis by enhancing cell survival. Also, insulin-like growth factor binding protein-3 (IGFBP-3) was reported to be a growth suppressor in variable pathways. Purpose of this study was to evaluate the state IGFR-1 and IGFBP-3 expression in patients with small cell lung cancer (SCLC) and its prognostic value. Methods: We analyzed IGFR-1 and IGFBP-3 expression in 194 SCLC tissues specimens by immunohistochemical stain. The relationship between IGFR-1 and IGFBP-3 expression and cliniopathological factors was evaluated. Univariate and multivariate analyses were performed to define its prognostic significance. Results: Median age was 63 years (range 38–85), 84% were men. One hundred-seventeen patients had extensive disease (60.3%), and 77 had limited disease (39.7%). With the median follow- up duration of 49.5 months (24–82), the median progression free survival (PFS) and overall survival (OS) were 8 months (95% CI: 7.3–8.7 months), and 14.4 months (95% CI: 12.7–16 months), respectively, The IGFR-1 expression was observed in 154 of 190 tumor tissues (79.4%), whereas there was no tissue stained by IGFBP-3. Multivariate analysis showed that stage (p<0.001), response to treatment (p<0.001), LDH level (p<0.001) were the independent prognostic factors for PFS, and age (p=0.014), LDH level (p<0.001), and stage (p<0.001) for OS. The IGFR-1 positivity was not associated with PFS or OS in the whole cohort. However, 84% of 115 extensive disease patients showed IGFR-1 positivity. The subgroup analysis revealed that OS was significantly longer for patients with IGFR-1 positive compared to those with IGFR-1 negative in extensive disease (11.3% vs 0% at 2year, p=0.034). Conclusions: These results suggest that IGFR-1 expression may be useful as a prognostic marker in patients with extensive disease of SCLC. No significant financial relationships to disclose.

The potential role of insulin-like growth factor receptor inhibitors in the treatment of advanced non-small cell lung cancer

2010 ◽  
Vol 19 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Cesare Gridelli ◽  
Antonio Rossi ◽  
Maria Anna Bareschino ◽  
Clorinda Schettino ◽  
Paola Claudia Sacco ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Potential Role ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Insulin Like Growth Factor ◽  
Small Cell Lung
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