Phase I trial combining temozolomide plus lapatinib for the treatment of brain metastases in patients with HER2-positive metastatic breast cancer: the LAPTEM trial

Brain Metastases ◽

Phase I ◽

Phase I Trial ◽

Metastatic Breast ◽

Faculty of 1000 evaluation for Phase I trial combining temozolomide plus lapatinib for the treatment of brain metastases in patients with HER2-positive metastatic breast cancer: the LAPTEM trial.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718102079.793485106 ◽

2013 ◽

Author(s):

Ana Maria Gonzalez-Angulo

Keyword(s):

Breast Cancer ◽

Brain Metastases ◽

Phase I ◽

Phase I Trial ◽

Metastatic Breast ◽

Phase I study of lapatinib (L) and temozolomide (T) combination for the treatment of progressive brain metastases (BM) in HER2-positive metastatic breast cancer patients (Pts) (LAPTEM, LAP 111172).

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.15_suppl.570 ◽

2011 ◽

Vol 29 (15_suppl) ◽

pp. 570-570 ◽

Cited By ~ 2

Author(s):

E. De Azambuja ◽

M. Lemort ◽

J. R. Rossari ◽

C. Moulin ◽

A. Buttice ◽

...

Keyword(s):

Breast Cancer ◽

Brain Metastases ◽

Phase I ◽

Cancer Patients ◽

Phase I Study ◽

Metastatic Breast ◽

Breast Cancer Patients ◽

Abstract P4-12-24: Phase I trial of S-222611, a dual tyrosine kinase inhibitor of EGFR and HER2, with preliminary evidence of efficacy in patients (pts) with heavily-pretreated HER2-positive metastatic breast cancer

10.1158/0008-5472.sabcs13-p4-12-24 ◽

2013 ◽

Cited By ~ 1

Author(s):

RD Baird ◽

N Cresti ◽

E Beddowes ◽

M Saggese ◽

M Flynn ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Tyrosine Kinase Inhibitor ◽

Phase I Trial ◽

Kinase Inhibitor ◽

Metastatic Breast ◽

Preliminary Evidence ◽

Her2 Positive ◽

Heavily Pretreated

Phase I Trial of Panobinostat (LBH589) in Combination with Trastuzumab in Pretreated HER2-Positive Metastatic Breast Cancer (mBC): Preliminary Safety, Efficacy and Pharmacokinetic Results.

10.1158/0008-5472.sabcs-09-6101 ◽

2009 ◽

Cited By ~ 5

Author(s):

M. Campone ◽

P. Conte ◽

D. Amadori ◽

P. Pronzato ◽

A. Wardley ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Phase I Trial ◽

Metastatic Breast ◽

A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer

Clinical Breast Cancer ◽

10.1016/j.clbc.2017.10.014 ◽

2018 ◽

Vol 18 (4) ◽

pp. 289-297 ◽

Cited By ~ 9

Author(s):

Autumn J. McRee ◽

Paul K. Marcom ◽

Dominic T. Moore ◽

William C. Zamboni ◽

Zachary A. Kornblum ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Phase I Trial ◽

Metastatic Breast ◽

Pi3k Inhibitor

122 O - A phase I trial of epirubicin (E) and paclitaxel (P) in patients with metastatic breast cancer (MBC)

European Journal of Cancer ◽

10.1016/0959-8049(96)84879-9 ◽

1996 ◽

Vol 32 ◽

pp. S24

Author(s):

R. Salyadori ◽

A. Mlchelotti ◽

E. Baldini ◽

A. Gennari ◽

C. Tibaldi ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Phase I Trial ◽

Metastatic Breast

Phase I trial of liposomal doxorubicin and ZD1839 in patients with refractory gynecological malignancies or metastatic breast cancer

International Journal of Clinical Oncology ◽

10.1007/s10147-010-0073-6 ◽

2010 ◽

Vol 15 (4) ◽

pp. 390-398 ◽

Cited By ~ 4

Author(s):

Susana M. Campos ◽

Suzanne T. Berlin ◽

Leroy M. Parker ◽

Wendy Y. Chen ◽

Craig A. Bunnell ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Phase I Trial ◽

Liposomal Doxorubicin ◽

Metastatic Breast ◽

Gynecological Malignancies

Trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer and brain metastases: exploratory final analysis of cohort 1 from KAMILLA, a single-arm phase IIIb clinical trial☆

Annals of Oncology ◽

10.1016/j.annonc.2020.06.020 ◽

2020 ◽

Vol 31 (10) ◽

pp. 1350-1358 ◽

Cited By ~ 9

Author(s):

F. Montemurro ◽

S. Delaloge ◽

C.H. Barrios ◽

R. Wuerstlein ◽

A. Anton ◽

...

Keyword(s):

Breast Cancer ◽

Clinical Trial ◽

Brain Metastases ◽

Metastatic Breast ◽

Final Analysis ◽

Trastuzumab Emtansine ◽

Her2 Positive ◽

Phase Iiib

Abstract P5-20-13: Preliminary report of a phase I/II study of entinostat (IND#NSC 706995, /M275) and lapatinib (IND#NSC 727989) in patients with HER2-positive metastatic breast cancer in whom trastuzumab has failed

10.1158/0008-5472.sabcs12-p5-20-13 ◽

2012 ◽

Author(s):

NT Ueno ◽

SA Jackson ◽

RH Alvarez ◽

JS Willey ◽

GN Hortobagyi ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Preliminary Report ◽

Metastatic Breast ◽

Abstract 5468: GEP01: A phase I pharmacokinetic study of lapatinib and iv vinorelbine in the treatment of HER2-positive locally advanced or metastatic breast cancer

10.1158/1538-7445.am2011-5468 ◽

2011 ◽

Author(s):

Keyvan Rezai ◽

Nicolas Isambert ◽

Etienne Brain ◽

Florence Dalenc ◽

Saïk Urien ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Pharmacokinetic Study ◽

Locally Advanced ◽

Metastatic Breast ◽