122PD Stereotactic statistical analysis of brain perfusion SPECT using 3-dimensional stereotactic surface projections to estimate brain function of the patients harboring brain metastases before and after radiotherapy

Summary Objective: The purpose of this study is to investigate the impact of cognitive group therapy and happiness training objectively in the local cerebral blood flow of patients with major depression (MD). Patients, material, methods: The present research is semi-experimental to pre- and post-test with a control group. Three groups were formed, and this number was incorporated in each group: 12 patients were chosen randomly; the first group of depressed patients benefited from the combination of pharmacotherapy and sessions of cognitive group therapy; the second group used a combination of pharmaco- therapy and sessions of happiness training; and a third group used only pharmacother- apy. We compared cognitive-behavioural therapy and happiness training efficacy with only pharmacotherapy in MD patients. We performed brain perfusion SPECT in each group, before and after each trial. Results: The study was conducted on 36 patients with MD (32 women and 4 men; mean age: 41.22 ± 9.08; range: 27-65 years). There were significant differences regarding the two trial effects into two experimental groups (p < 0/001) before and after trials, while such differences were not significant in the control group (p > 0.05). In addition, there was significant difference among the regional cerebral blood flow in the frontal and prefrontal regions into two experimental groups before and after trials (p < 0/001), while such differences were not significant in the control group (p > 0.05). Conclusion: This study demonstrated decreased cerebral perfusion in the frontal regions in MD patients, which increased following cognitive group therapy and happiness training. Because of its availability, low costs, easy performance, and the objective semi-quantitative information supplied, brain perfusion SPECT

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Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang’s method

Annals of Nuclear Medicine ◽

10.1007/s12149-020-01477-4 ◽

2020 ◽

Vol 34 (7) ◽

pp. 502-511

Author(s):

Koji Sohara ◽

Tomonari Kiriyama ◽

Sunao Mizumura ◽

Akiko Ishiwata ◽

Mineo Yamazaki ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Statistical Analysis ◽

Attenuation Correction ◽

Brain Perfusion ◽

Diagnostic Utility ◽

Brain Perfusion Spect ◽

Perfusion Spect

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Development of cerebral microbleeds in patients with cerebral hyperperfusion following carotid endarterectomy and its relation to postoperative cognitive decline

Journal of Neurosurgery ◽

10.3171/2020.7.jns202353 ◽

2021 ◽

pp. 1-7

Author(s):

Suguru Igarashi ◽

Toshihiko Ando ◽

Tatsuhiko Takahashi ◽

Jun Yoshida ◽

Masakazu Kobayashi ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Cognitive Decline ◽

Carotid Endarterectomy ◽

Brain Perfusion ◽

Brain Perfusion Spect ◽

Cerebral Hyperperfusion ◽

Postoperative Cognitive Decline ◽

Before And After ◽

Perfusion Spect

OBJECTIVEA primary cause of cognitive decline after carotid endarterectomy (CEA) is cerebral injury due to cerebral hyperperfusion. However, the mechanisms of how cerebral hyperperfusion induces cerebral cortex and white matter injury are not known. The presence of cerebral microbleeds (CMBs) on susceptibility-weighted imaging (SWI) is independently associated with a decline in global cognitive function. The purpose of this prospective observational study was to determine whether cerebral hyperperfusion following CEA leads to the development of CMBs and if postoperative cognitive decline is related to these developed CMBs.METHODSDuring the 27-month study period, patients who underwent CEA for ipsilateral internal carotid artery stenosis (≥ 70%) also underwent SWI and neuropsychological testing before and 2 months after surgery, as well as quantitative brain perfusion SPECT prior to and immediately after surgery.RESULTSAccording to quantitative brain perfusion SPECT and SWI before and after surgery, 12 (16%) and 7 (9%) of 75 patients exhibited postoperative cerebral hyperperfusion and increased CMBs in the cerebral hemisphere ipsilateral to surgery, respectively. Cerebral hyperperfusion was associated with an increase in CMBs after surgery (logistic regression analysis, 95% CI 5.08–31.25, p < 0.0001). According to neuropsychological assessments before and after surgery, 10 patients (13%) showed postoperative cognitive decline. Increased CMBs were associated with cognitive decline after surgery (logistic regression analysis, 95% CI 6.80–66.67, p < 0.0001). Among the patients with cerebral hyperperfusion after surgery, the incidence of postoperative cognitive decline was higher in those with increased CMBs (100%) than in those without (20%; p = 0.0101).CONCLUSIONSCerebral hyperperfusion following CEA leads to the development of CMBs, and postoperative cognitive decline is related to these developed CMBs.

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Brain perfusion SPECT and MRI in foetal alcohol syndrome

Developmental Medicine & Child Neurology ◽

10.1017/s0012162299001358 ◽

1999 ◽

Vol 41 (10) ◽

pp. 652-659 ◽

Cited By ~ 101

Author(s):

R Riikonen ◽

I Salonen ◽

K Partanen ◽

S Verho

Keyword(s):

Brain Perfusion ◽

Brain Perfusion Spect ◽

Foetal Alcohol Syndrome ◽

Perfusion Spect

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High-quality brain perfusion SPECT images may be achieved with a high-speed recording using 360° CZT camera

EJNMMI Physics ◽

10.1186/s40658-020-00334-7 ◽

2020 ◽

Vol 7 (1) ◽

Author(s):

Manon Bordonne ◽

Mohammad B. Chawki ◽

Pierre-Yves Marie ◽

Timothée Zaragori ◽

Véronique Roch ◽

...

Keyword(s):

Image Quality ◽

High Speed ◽

Brain Perfusion ◽

Fold Increase ◽

Brain Structures ◽

Czt Camera ◽

Recording Time ◽

Brain Perfusion Spect ◽

Central Brain ◽

Perfusion Spect

Abstract Objective The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera. Methods The 360° CZT camera utilizing a brain configuration, with 12 detectors surrounding the head, was compared to a 2-head Anger camera for count sensitivity and image quality on 30-min SPECT recordings from a brain phantom and from 99mTc-HMPAO brain perfusion in 2 groups of 21 patients investigated with the CZT and Anger cameras, respectively. Image reconstruction was adjusted according to image contrast for each camera. Results The CZT camera provided more than 2-fold increase in count sensitivity, as compared with the Anger camera, as well as (1) lower sharpness indexes, giving evidence of higher spatial resolution, for both peripheral/central brain structures, with respective median values of 5.2%/3.7% versus 2.4%/1.9% for CZT and Anger camera respectively in patients (p < 0.01), and 8.0%/6.9% versus 6.2%/3.7% on phantom; and (2) higher gray/white matter contrast on peripheral/central structures, with respective ratio median values of 1.56/1.35 versus 1.11/1.20 for CZT and Anger camera respectively in patients (p < 0.05), and 2.57/2.17 versus 1.40/1.12 on phantom; and (3) no change in noise level. Image quality, scored visually by experienced physicians, was also significantly higher on CZT than on the Anger camera (+ 80%, p < 0.01), and all these results were unchanged on the CZT images obtained with only a 15 min recording time. Conclusion The 360° CZT camera provides brain perfusion images of much higher quality than a conventional Anger camera, even with high-speed recordings, thus demonstrating the potential for repositioning brain perfusion SPECT to the forefront of brain imaging.

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