scholarly journals Characterizing the DNA damage response in putative stem cells of resected normal lung and matched NSCLC patient samples

2017 ◽  
Vol 28 ◽  
pp. ii4
Author(s):  
T.M. Marti ◽  
C.C. Tièche ◽  
R. Peng ◽  
S.R.R. Hall ◽  
L. Froment ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Nsclc Patient ◽  
Normal Lung ◽  
Damage Response

scholarly journals Lack of DNA Damage Response at Low Radiation Doses in Adult Stem Cells Contributes to Organ Dysfunction

2018 ◽  
Vol 24 (24) ◽  
pp. 6583-6593 ◽  
Author(s):  
Peter W. Nagle ◽  
Nynke A. Hosper ◽  
Lara Barazzuol ◽  
Anne L. Jellema ◽  
Mirjam Baanstra ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Organ Dysfunction ◽  
Dna Damage Response ◽  
Adult Stem Cells ◽  
Radiation Doses ◽  
Damage Response ◽  
Low Radiation Doses

scholarly journals DNA Damage Response/Repair in Cancer Stem Cells — Potential vs. Controversies

10.5772/61355 ◽  
2015 ◽  
Author(s):  
Maria Louka ◽  
Effrossyni Boutou ◽  
Vasiliki Bakou ◽  
Vassiliki Pappa ◽  
Anastasios Georgoulis ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations

2016 ◽  
Vol 186 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Kalpana Mujoo ◽  
E. Brian Butler ◽  
Raj K. Pandita ◽  
Clayton R. Hunt ◽  
Tej K. Pandita
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Pluripotent Stem Cells ◽  
Damage Response ◽  
Ionizing Radiations

Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

2013 ◽  
Vol 6 (259) ◽  
pp. ra5-ra5 ◽  
Author(s):  
J. Carreras Puigvert ◽  
L. von Stechow ◽  
R. Siddappa ◽  
A. Pines ◽  
M. Bahjat ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Systems Biology ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Damage Response

scholarly journals Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells

2012 ◽  
Vol 46 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Mangmang Li ◽  
Yunlong He ◽  
Wendy Dubois ◽  
Xiaolin Wu ◽  
Jianxin Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Regulatory Mechanisms ◽  
Damage Response

scholarly journals Stemness factor Sall4 is required for DNA damage response in embryonic stem cells

2015 ◽  
Vol 208 (5) ◽  
pp. 513-520 ◽  
Author(s):  
Jianhua Xiong ◽  
Dilyana Todorova ◽  
Ning-Yuan Su ◽  
Jinchul Kim ◽  
Pei-Jen Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Ataxia Telangiectasia Mutated ◽  
Mouse Escs ◽  
Chromatin Remodeling Complex ◽  
Damage Response ◽  
Underlying Mechanisms

Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper, we show that the stemness factor Sall4 is required for activating the critical Ataxia Telangiectasia Mutated (ATM)–dependent cellular responses to DNA double-stranded breaks (DSBs) in mouse ESCs and confer their resistance to DSB-induced cytotoxicity. Sall4 is rapidly mobilized to the sites of DSBs after DNA damage. Furthermore, Sall4 interacts with Rad50 and stabilizes the Mre11–Rad50–Nbs1 complex for the efficient recruitment and activation of ATM. Sall4 also interacts with Baf60a, a member of the SWI/SNF (switch/sucrose nonfermentable) ATP-dependent chromatin-remodeling complex, which is responsible for recruiting Sall4 to the site of DNA DSB damage. Our findings provide novel mechanisms to coordinate stemness of ESCs with DNA damage response, ensuring genomic stability during the expansion of ESCs.

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