Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells

2013 ◽  
Vol 6 (259) ◽  
pp. ra5-ra5 ◽  
Author(s):  
J. Carreras Puigvert ◽  
L. von Stechow ◽  
R. Siddappa ◽  
A. Pines ◽  
M. Bahjat ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Systems Biology ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Damage Response

scholarly journals Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells

2012 ◽  
Vol 46 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Mangmang Li ◽  
Yunlong He ◽  
Wendy Dubois ◽  
Xiaolin Wu ◽  
Jianxin Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Regulatory Mechanisms ◽  
Damage Response

scholarly journals Stemness factor Sall4 is required for DNA damage response in embryonic stem cells

2015 ◽  
Vol 208 (5) ◽  
pp. 513-520 ◽  
Author(s):  
Jianhua Xiong ◽  
Dilyana Todorova ◽  
Ning-Yuan Su ◽  
Jinchul Kim ◽  
Pei-Jen Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Ataxia Telangiectasia Mutated ◽  
Mouse Escs ◽  
Chromatin Remodeling Complex ◽  
Damage Response ◽  
Underlying Mechanisms

Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper, we show that the stemness factor Sall4 is required for activating the critical Ataxia Telangiectasia Mutated (ATM)–dependent cellular responses to DNA double-stranded breaks (DSBs) in mouse ESCs and confer their resistance to DSB-induced cytotoxicity. Sall4 is rapidly mobilized to the sites of DSBs after DNA damage. Furthermore, Sall4 interacts with Rad50 and stabilizes the Mre11–Rad50–Nbs1 complex for the efficient recruitment and activation of ATM. Sall4 also interacts with Baf60a, a member of the SWI/SNF (switch/sucrose nonfermentable) ATP-dependent chromatin-remodeling complex, which is responsible for recruiting Sall4 to the site of DNA DSB damage. Our findings provide novel mechanisms to coordinate stemness of ESCs with DNA damage response, ensuring genomic stability during the expansion of ESCs.

scholarly journals LIF Insensitivity and Expression of Proteins Activated by DNA Damage Response in Teratoma-Isolated Cells Derived from Mouse Embryonic Stem Cells

CYTOLOGIA ◽  
2013 ◽  
Vol 78 (2) ◽  
pp. 195-202
Author(s):  
Alfredo Santana ◽  
Nestor Vicente-salar ◽  
Raimundo Freire ◽  
Juan A Reig ◽  
Enrique Roche
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Isolated Cells ◽  
Damage Response

scholarly journals Stemness factor Sall4 is required for DNA damage response in embryonic stem cells

2015 ◽  
Vol 212 (3) ◽  
pp. 2123OIA6
Author(s):  
J. Xiong ◽  
D. Todorova ◽  
N Su ◽  
J. Kim ◽  
P Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Damage Response

scholarly journals Activation of DNA damage response signaling in mouse embryonic stem cells

Cell Cycle ◽  
2008 ◽  
Vol 7 (18) ◽  
pp. 2922-2928 ◽  
Author(s):  
Ilya A. Chuykin ◽  
Maria S. Lianguzova ◽  
Tatiana V. Pospelova ◽  
Valery A. Pospelov
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Damage Response

scholarly journals MicroRNAs Regulate p21Waf1/Cip1 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells

Stem Cells ◽  
2012 ◽  
Vol 30 (7) ◽  
pp. 1362-1372 ◽  
Author(s):  
Dasa Dolezalova ◽  
Marek Mraz ◽  
Tomas Barta ◽  
Karla Plevova ◽  
Vladimir Vinarsky ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Protein Expression ◽  
Dna Damage Response ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Damage Response

scholarly journals An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells

Stem Cells ◽  
2011 ◽  
Vol 29 (4) ◽  
pp. 651-659 ◽  
Author(s):  
Irina Neganova ◽  
Felipe Vilella ◽  
Stuart P. Atkinson ◽  
Maria Lloret ◽  
João F. Passos ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Embryonic Stem Cells ◽  
Dna Damage Response ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Checkpoint Activation ◽  
Damage Response
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