Role of cancer ratio and carcinogenic embryonic antigen ratio in diagnosis of pleural effusion

Abstract Background The Middle East respiratory syndrome coronavirus (MERS-Cov) continues to be a source of concern due to intermittent outbreaks. Serial chest radiographic changes in MERS-Cov patients were analyzed for various variables that could be compared to the patients’ final outcomes in a cluster of MERS-Cov patients and to identify a predictor of mortality in the United Arab Emirates. Results A total of 44 MERS-Cov cases were reviewed. The mean age of the patients was 43.7 ± 14.7 years. The chest radiograph was abnormal in 14/44 (31.8%). The commonest radiology features include ground-glass opacities (seven of 14, 50%), ground-glass and consolidation (seven of 14, 50%), pleural effusion (eight of 14, 57.1%), and air bronchogram (three of 14, 21.4%). The mortality rate was 13.6% (six of 44); the deceased group (6 of 44, 13.6%) was associated with significantly higher incidence of mechanical ventilation (p < 0.001), pleural effusion (p < 0.001), chest radiographic score (8.90 ± 6.31, p < 0.001), and type 4 radiographic progression of disease (p < 0.001). A chest radiographic score at presentation was seen to be an independent and strong predictor of mortality (OR [95% confidence interval] 3.20 [1.35, 7.61]). The Cohen κ coefficient for the interobserver agreement was k = 0.89 (p = 0.001). Conclusion The chest radiographic score, associated with a higher degree of disease progression (type 4), particularly in patients with old age or with comorbidity, may indicate a poorer prognosis in MERS-Cov infection, necessitating intensive care unit management or predicting impending death.

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The role of PET-CT in differential diagnosis of malignant-paramalignant pleural effusion

Southern Clinics of Istanbul Eurasia ◽

10.14744/scie.2019.42104 ◽

2019 ◽

Author(s):

Bülent Akkurt

Keyword(s):

Differential Diagnosis ◽

Pleural Effusion ◽

Pet Ct

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The role of genexpert in the diagnosis of tubercular pleural effusion in India

Advances in respiratory medicine ◽

10.5603/arm.2019.0049 ◽

2019 ◽

Vol 87 (5) ◽

pp. 276-280

Author(s):

Anushree Chakraborty ◽

Swapna Ramaswamy ◽

Akshata Jayachamrajpura Shivananjiah ◽

Raghu Bokkikere Puttaswamy ◽

Nagaraja Chikkavenkatappa

Keyword(s):

Pleural Effusion

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Role of Intrapleural Pressure in the Positional Effect on Gas Exchange in Unilateral Pleural Effusion

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.1984.31.4.176 ◽

1984 ◽

Vol 31 (4) ◽

pp. 176-182

Author(s):

Dong Cheol Han ◽

Soo Taek Uh ◽

Byung Soo Ahn ◽

Taek Jun Kim ◽

Choon Sik Park

Keyword(s):

Pleural Effusion ◽

Gas Exchange ◽

Intrapleural Pressure ◽

Positional Effect

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The Role of Cytokine profile detection in Myelomatous pleural effusions

10.21203/rs.3.rs-363841/v1 ◽

2021 ◽

Author(s):

Junhui Xu ◽

Liang Gao ◽

Miao Yan ◽

Bingjie Wang ◽

Zhengyang Song ◽

...

Keyword(s):

Multiple Myeloma ◽

Pleural Effusion ◽

Cytokine Profile ◽

Pleural Effusions ◽

Case Presentation ◽

Cytokine Detection ◽

Tnf Α ◽

Tumor Load ◽

Poor Outcomes

Abstract Background: Myelomatous pleural effusion (MPE), as a presentation of extramedullary infiltration of multiple myeloma (MM), is rare and associated with poor outcomes without comparatively effective treatment now. The value of the cytokine detection in pleural effusions to MPE has not been reported at present. Case presentation: We herein report a case of refractory and relapsed multiple myeloma which developed bilateral MPE due to disease progression caused by intolerance to various chemotherapy regimens. The cytomorphology and flow cytometry is adopted in the diagnosis confirmation. The chemotherapy containing immunomodulators combined with thoracic catheterization drainage is applied to the patient, showing a certain therapeutic effect. During the course of disease, the changes of cytokine profile in pleural effusion were monitored by Biolegend CBA technology, revealing that the cytokines such as IL-6 and IL-10 related to the tumor load in pleural effusion decreased with the improvement of the disease, while IL-2, IL-4, IL-17A, TNF - α, INF - γ, granzyme A, Granzyme B, perforin and granulysin increased with the improvement of the disease. Conclusions: There is a prospect that the cytokines level in pleural effusion becomes an indication to evaluate treatment response of MPE, and in the light of our finding, immunomodulators, IL-2 and INF - γ may be utilized in treating patients suffering MPE.

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Role of chest radiation in extensive-stage small cell lung cancer with ipsilateral pleural effusion.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e20567 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e20567-e20567

Author(s):

Takefumi Komiya ◽

Emily Powell ◽

Charles Vu ◽

Shinkichi Takamori

Keyword(s):

Lung Cancer ◽

Pleural Effusion ◽

Small Cell Lung Cancer ◽

Survival Benefit ◽

Multivariate Analyses ◽

Small Cell ◽

Hazard Ratio ◽

Small Cell Lung ◽

Extensive Stage

e20567 Background: Prognosis of extensive-stage small cell lung cancer (ES-SCLC) remains poor. Previous randomized trials suggested consolidation chest radiation (CXRT) has a modest survival benefit; however, its role in subgroups of ES-SCLC, especially ipsilateral pleural effusion (IPE) have not been reported and unknown. Methods: Using National Cancer Database (NCDB), 283,347 ES-SCLC cases diagnosed between 2004 and 2017 were screened. Eligible cases must have been staged with 7th edition of staging system and have information about clinical T and N stage, and minimum follow-up of one month. Role of CXRT was examined in M1a, M1b, and IPE subgroups. Surveillance, Epidemiology, and End Results Program (SEER) was analyzed to independently validate our results. Univariate and multivariate analyses were conducted with Cox proportional hazard models. A p-value < 0.05 was considered as statistically significant. Results: A total of 36,762 (5,511 with M1a, 31,251 with M1b, and 2,013 with IPE) cases were analyzed. In both M1a and IPE groups, use of CXRT was significantly associated with younger age, female sex, non-academic institution, and clinical T stage. Both univariate and multivariate analyses showed that use of CXRT demonstrated significantly longer overall survival in all the groups, with lower hazard ratios in the M1a and IPE groups than in the M1b group (univariate hazard ratio 0.62, 0.56, and 0.72, respectively). Propensity score analysis of the IPE group also showed a survival advantage in the CXRT group (hazard ratio 0.54). The SEER data also showed a survival advantage of CXRT in the IPE group (univariate hazard ratio of 0.40). Conclusions: This retrospective database analysis suggests M1a and in particular IPE subgroups have more survival benefit of CXRT than the M1b subgroup. Further studies are warranted to confirm the hypothesis.

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