A-166 Assuming Fine Motor Impairment in Pediatric Brain Tumor

2021 ◽  
Vol 36 (6) ◽  
pp. 1221-1221
Author(s):  
Dianne Kong ◽  
Viannae Carmona ◽  
Ashley M Whitaker

Abstract Objective As neuropsychologists adopt virtual assessments in the context of COVID-19, the field is shifting toward teleneuropsychology. Comprehensive remote evaluations are proving to be feasible and reliable across domains, though traditional fine motor (FM) tests cannot be administered virtually. In the absence of direct FM measurement, this cross-sectional study considered whether universal FM recommendations are appropriate for patients with pediatric brain tumor (PBT). Method Dominant FM z-scores were obtained from 176 patients with PBT (x- age at diagnosis and evaluation = 7.3 and 12.8 years, respectively). There were no significant differences between Lafayette Grooved and Purdue Pegboard performances. FM differences between tumor location (46% infratentorial), chemotherapy (71.6%), and gender (52.3% male) were analyzed. Results The sample as a whole performed over 2 SDs below normative age expectations, t(175) = −14.7, p < 0.0001), with more pronounced deficits among patients with infratentorial (x-= − 2.4) than supratentorial (x-= − 1.7) tumors, F(1,174) = 7.1, p = 0.008. Consistent with prior findings, patients performed worse when treated with chemotherapy (x-= − 2.3) than without (x-= − 1.7), F(1,174) = 16.2, p < 0.0001. Time since diagnosis was negatively correlated with FM performance r = −0.27, p < 0.001. While gender differences were not apparent overall, post-hoc analyses revealed FM impairment in over 89% of males and 75% of females by middle school. Conclusions Given the likelihood of FM concerns (particularly by middle school), FM recommendations should be offered even in the absence of direct FM measurement for patients with PBT evaluated virtually. Accommodations (e.g., note copies, typing/dictation, abbreviated assignments, extended time) are free/easy to implement and can be incorporated into medically based Section 504 Plans, while early intervention may mitigate long-term effects.

2021 ◽  
Author(s):  
Junxiang Peng ◽  
Svenja Boekhoff ◽  
Maria Eveslage ◽  
Brigitte Bison ◽  
Panjarat Sowithayasakul ◽  
...  

Abstract Background: Obesity, cardiovascular disease (CVD), and relapse/progression have impact on prognosis in pediatric brain tumor (BT) patients. Methods: In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI follow-up monitoring as a parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy controls (HC). Furthermore, BMI, waist-to-height ratio (WHtR), caliper-measured skinfold thickness (cSFT), and blood-pressure (BP) were analysed.Results: CP patients showed higher BMI, WHtR, NST and cSFT when compared with BT and HC. WHO grade 1–2 BT patients were observed with higher BMI, waist circumference and triceps cSFT when compared to WHO grade 3–4 BT patients. NST correlated with BMI, WHtR, and cSFT. NST, BMI and WHtR had predictive value for CVD in terms of increased BP. In multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14–1.379). In CP patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased. Conclusions: NST could serve as a novel useful parameter for assessment of BC and CVD risk in BT patients.


2021 ◽  
Vol 36 (6) ◽  
pp. 1225-1225
Author(s):  
Viannae Carmona ◽  
Dianne Kong ◽  
Ashley M Whitaker

Abstract Objective As the field of neuropsychology strives to provide equitable care among diverse and disadvantaged populations, disparities in treatment and long-term outcomes continue to disproportionately impact individuals of lower socioeconomic status (SES). Motor deficits are common following pediatric brain tumor (PBT) diagnoses. However, while the relationship between SES and cognitive outcomes in this population is well documented, the role of SES in predicting more basic motor outcomes is not yet understood. This retrospective cross-sectional study was designed to determine the impact of SES on fine motor and graphomotor outcomes in PBT patients to ensure appropriate interventions and accommodations for those at higher risk. Method 225 patients with PBT (52.9% male; $ \overset{-}{\textrm{x}} $ age = 12 yrs; SD = 5.3 yrs) underwent neuropsychological evaluation, including assessment of graphomotor speed/coordination, visual-motor integration, and fine motor dexterity. Estimated median household income was used as a proxy for SES ($ \overset{-}{\textrm{x}} $=$71,543; SD = $23,480). Linear regression analyses were used to explore the role of SES in predicting motor outcomes. Results Lower SES predicted poorer graphomotor speed, F(1,96) = 5.205, p = 0.013, graphomotor coordination, F(1,60) = 3.890, p = 0.027, visual-motor integration, F(1,88) = 8.116, p = 0.003, and fine motor dexterity, F(1,166) = 3.755, p = 0.027. All analyses were significant even after implementing false discovery rates. Conclusions Consistent with lower SES predicting poorer cognitive late effects, SES also plays a role in motor-related outcomes of PBT. Unfortunately, lower SES is also associated with barriers in accessing formal evaluations and services required to mitigate such deficits. Therefore, patients with lower SES should be considered higher risk and receive interventions and accommodations even in the absence of formal assessment to prevent delays in care.


2008 ◽  
Vol 33 (4) ◽  
pp. 505-520 ◽  
Author(s):  
Aimilia Papazoglou ◽  
Tricia Z. King ◽  
Robin D. Morris ◽  
Nicolas S. Krawiecki

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii455-iii455
Author(s):  
Junxiang Peng ◽  
Svenja Boekhoff ◽  
Maria Eveslage ◽  
Brigitte Bison ◽  
Panjarat Sowithayasakul ◽  
...  

Abstract BACKGROUND Obesity, cardiovascular disease (CVD), and relapse/progression have major impact on prognosis in pediatric brain tumor (BT) patients. Cranial MRI is part of routine follow-up. METHODS In a cross-sectional study, we analyzed nuchal skinfold thickness (NST) on MRI performed for BT follow-up monitoring as a novel parameter for body composition (BC) and CVD in 177 BT patients (40 WHO grade 1–2 BT; 31 grade 3–4 BT; 106 craniopharyngioma (CP)), and 53 healthy controls (HC). Associations of NST with body mass index (BMI), waist-to-height ratio (WHtR), caliper-measured skinfold thickness (cSFT), and blood pressure (BP) were analysed in BT and HC. RESULTS CP patients showed higher BMI, WHtR, NST and cSFT when compared with BT and HC, whereas these differences were not detectable between BT and HC. However, WHO grade 1–2 BT patients were observed with higher BMI, waist circumference and triceps cSFT when compared to WHO grade 3–4 BT patients. NST showed high correlations with BMI, WHtR, and cSFT. NST, BMI and WHtR had predictive value for CVD in terms of increased BP, and in multivariate analysis, only BMI was selected for the final model resulting in an odds ratio of 1.25 (1.14–1.379). In CP patients with hypothalamic involvement/lesion or gross-total resection, rate and degree of obesity were increased. CONCLUSIONS As monitoring of MRI and BC play an important role in follow-up after BT, NST could serve as a novel useful parameter for assessment of BC and CVD risk in BT patients.


2012 ◽  
Vol 224 (06) ◽  
Author(s):  
T Milde ◽  
M Zucknick ◽  
M Kool ◽  
A Korshunov ◽  
H Witt ◽  
...  

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