scholarly journals Combined magnetic resonance imaging and positron emission tomography brain imaging in behavioural variant frontotemporal degeneration: refining the clinical phenotype

Brain ◽  
2009 ◽  
Vol 132 (9) ◽  
pp. 2566-2578 ◽  
Author(s):  
C. M. Kipps ◽  
J. R. Hodges ◽  
T. D. Fryer ◽  
P. J. Nestor
Author(s):  
Saugat Bhattacharyya ◽  
Anwesha Khasnobish ◽  
Poulami Ghosh ◽  
Ankita Mazumder ◽  
D. N. Tibarewala

Evolution has endowed human race with the most adroit brain, and to harness its potential to the fullest the concept of brain computer interface (BCI) has emerged. One of the most crucial components of BCI is the technique of brain imaging. The first approach in the field of brain imaging was to measure the electrical and magnetic activity of the brain, the techniques being known as Electroencephalography and Magnetoencephalography. Striving for furtherance, researchers came up with another alternative known as Magnetic Resonance Imaging. But it being confined to only structural imaging, the functional aspects of brain were mapped using functional magnetic resonance imaging. A similar but comparatively newer neuroimaging modality is Functional Near Infrared Spectroscopy. Transcranial Magnetic Stimulation neuro-physiological technique is based on the principle of electromagnetic induction. Based on nuclear medicine the brain imaging technologies that are widely explored in the world of BCI are Positron Emission Tomography and Single Positron Emission Tomography.


1986 ◽  
Vol 31 (7) ◽  
pp. 675-680 ◽  
Author(s):  
Trevor Young ◽  
Peter Williamson

The application of brain imaging techniques to psychiatry is reviewed with respect to computerized tomography (CT), EEG topography, positron emission tomography (PET), and magnetic resonance imaging (MRI). While early computerized tomography studies have suggested structural abnormalities in schizophrenia, more recent studies have shown that most schizophrenics and patients with other disorders have normal CT scans. EEG topography and positron emission tomography have not been evaluated as fully as computerized tomography. However, preliminary studies indicate some functional abnormalities in schizophrenia and affective disorders compared to normal controls. Magnetic resonance imaging shows promise but has had only a limited application to date in psychiatry.


2017 ◽  
pp. 300-330 ◽  
Author(s):  
Saugat Bhattacharyya ◽  
Anwesha Khasnobish ◽  
Poulami Ghosh ◽  
Ankita Mazumder ◽  
D. N. Tibarewala

Evolution has endowed human race with the most adroit brain, and to harness its potential to the fullest the concept of brain computer interface (BCI) has emerged. One of the most crucial components of BCI is the technique of brain imaging. The first approach in the field of brain imaging was to measure the electrical and magnetic activity of the brain, the techniques being known as Electroencephalography and Magnetoencephalography. Striving for furtherance, researchers came up with another alternative known as Magnetic Resonance Imaging. But it being confined to only structural imaging, the functional aspects of brain were mapped using functional magnetic resonance imaging. A similar but comparatively newer neuroimaging modality is Functional Near Infrared Spectroscopy. Transcranial Magnetic Stimulation neuro-physiological technique is based on the principle of electromagnetic induction. Based on nuclear medicine the brain imaging technologies that are widely explored in the world of BCI are Positron Emission Tomography and Single Positron Emission Tomography.


2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Sangwoo Kim ◽  
Youngjeon Lee ◽  
Chang-Yeop Jeon ◽  
Yeung Bae Jin ◽  
Sukhoon Oh ◽  
...  

Abstract Background Although the thalamus is known to modulate basal ganglia function related to motor control activity, the abnormal changes within the thalamus during distinct medical complications have been scarcely investigated. In order to explore the feasibility of assessing iron accumulation in the thalamus as an informative biomarker for Parkinson’s disease (PD), this study was designed to employ quantitative susceptibility mapping using a 7 T magnetic resonance imaging system in cynomolgus monkeys. A 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-injected cynomolgus monkey and a healthy control (HC) were examined by 7 T magnetic resonance imaging. Positron emission tomography with 18F-N-(3-fluoro propyl)-2ß-carboxymethoxy-3ß-(4-iodophenyl) nortropane was also employed to identify the relationship between iron deposits and dopamine depletion. All acquired values were averaged within the volume of interest of the nigrostriatal pathway. Findings Compared with the HC, the overall elevation of iron deposition within the thalamus in the Parkinson’s disease model (about 53.81% increase) was similar to that in the substantia nigra (54.81%) region. Substantial susceptibility changes were observed in the intralaminar part of the thalamus (about 70.78% increase). Additionally, we observed that in the Parkinson’s disease model, binding potential values obtained from positron emission tomography were considerably decreased in the thalamus (97.51%) and substantia nigra (92.48%). Conclusions The increased iron deposition in the thalamus showed negative correlation with dopaminergic activity in PD, supporting the idea that iron accumulation affects glutaminergic inputs and dopaminergic neurons. This investigation indicates that the remarkable susceptibility changes in the thalamus could be an initial major diagnostic biomarker for Parkinson’s disease-related motor symptoms.


Sign in / Sign up

Export Citation Format

Share Document