scholarly journals Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Allen A Champagne ◽  
Emile Peponoulas ◽  
Itamar Terem ◽  
Andrew Ross ◽  
Maryam Tayebi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
White Matter Tract ◽  
Exposure Group ◽  
Resonance Imaging ◽  
High Exposure

Abstract Increasing evidence for the cumulative effects of head trauma on structural integrity of the brain has emphasized the need to understand the relationship between tissue mechanic properties and injury susceptibility. Here, diffusion tensor imaging, helmet accelerometers and amplified magnetic resonance imaging were combined to gather insight about the region-specific vulnerability of the corpus callosum to microstructural changes in white-matter integrity upon exposure to sub-concussive impacts. A total of 33 male Canadian football players (meanage = 20.3 ± 1.4 years) were assessed at three time points during a football season (baseline pre-season, mid-season and post-season). The athletes were split into a LOW (N = 16) and HIGH (N = 17) exposure group based on the frequency of sub-concussive impacts sustained on a per-session basis, measured using the helmet-mounted accelerometers. Longitudinal decreases in fractional anisotropy were observed in anterior and posterior regions of the corpus callosum (average cluster size = 40.0 ± 4.4 voxels; P < 0.05, corrected) for athletes from the HIGH exposure group. These results suggest that the white-matter tract may be vulnerable to repetitive sub-concussive collisions sustained over the course of a football season. Using these findings as a basis for further investigation, a novel exploratory analysis of strain derived from sub-voxel motion of brain tissues in response to cardiac impulses was developed using amplified magnetic resonance imaging. This approach revealed specific differences in strain (and thus possibly stiffness) along the white-matter tract (P < 0.0001) suggesting a possible signature relationship between changes in white-matter integrity and tissue mechanical properties. In light of these findings, additional information about the viscoelastic behaviour of white-matter tissues may be imperative in elucidating the mechanisms responsible for region-specific differences in injury susceptibility observed, for instance, through changes in microstructural integrity following exposure to sub-concussive head impacts.

White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults

2010 ◽  
Vol 3 (5) ◽  
pp. 203-213 ◽  
Author(s):  
Oswald J.N. Bloemen ◽  
Quinton Deeley ◽  
Fred Sundram ◽  
Eileen M. Daly ◽  
Gareth J. Barker ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Asperger Syndrome ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
White Matter Integrity ◽  
Magnetic Resonance Imaging Study ◽  
Resonance Imaging

White matter integrity in Asperger syndrome: A preliminary diffusion tensor magnetic resonance imaging study in adults

2011 ◽  
Vol 4 (2) ◽  
pp. 160-160
Author(s):  
Oswald J.N. Bloemen ◽  
Quinton Deeley ◽  
Fred Sundram ◽  
Eileen M. Daly ◽  
Gareth J. Barker ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Asperger Syndrome ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
White Matter Integrity ◽  
Magnetic Resonance Imaging Study ◽  
Resonance Imaging

scholarly journals Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study

2003 ◽  
Vol 182 (5) ◽  
pp. 439-443 ◽  
Author(s):  
J. Burns ◽  
D. Job ◽  
M. E. Bastin ◽  
H. Whalley ◽  
T. Macgillivray ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Fractional Anisotropy ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Uncinate Fasciculus ◽  
Arcuate Fasciculus ◽  
Resonance Imaging ◽  
White Matter Tracts

BackgroundThere is growing evidence that schizophrenia is a disorder of cortical connectivity Specifically, frontotemporal and frontoparietal connections are thought to be functionally impaired. Diffusion tensor magnetic resonance imaging (DT–MRI) is a technique that has the potential to demonstrate structural disconnectivity in schizophrenia.AimsTo investigate the structural integrity of frontotemporal and frontoparietal white matter tracts in schizophrenia.MethodThirty patients with DSM–IV schizophrenia and thirty matched control subjects underwent DT–MRI and structural MRI. Fractional anisotropy – an index of the integrity of white matter tracts – was determined in the uncinate fasciculus, the anterior cingulum and the arcuate fasciculus and analysed using voxel-based morphometry.ResultsThere was reduced fractional anisotropy in the left uncinate fasciculus and left arcuate fasciculus in patients with schizophrenia compared with controls.ConclusionsThe findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fasciculus suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia.

scholarly journals A Connectomic Atlas of the Human Cerebrum—Chapter 13: Tractographic Description of the Inferior Fronto-Occipital Fasciculus

2018 ◽  
Vol 15 (suppl_1) ◽  
pp. S436-S443 ◽  
Author(s):  
Andrew K Conner ◽  
Robert G Briggs ◽  
Goksel Sali ◽  
Meherzad Rahimi ◽  
Cordell M Baker ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Language Processing ◽  
White Matter Tract ◽  
Resonance Imaging ◽  
Large White ◽  
Human Cortex ◽  
Human Connectome Project ◽  
And Function

ABSTRACT The inferior fronto-occipital fasciculus (IFOF) is a large white matter tract of the human cerebrum with functional connectivity associated with semantic language processing and goal-oriented behavior. However, little is known regarding the overall connectivity of this tract. Recently, the Human Connectome Project parcellated the human cortex into 180 distinct regions. In our other work, we have shown these various regions in relation to clinically applicable anatomy and function. Utilizing Diffusion Spectrum Magnetic Resonance Imaging tractography coupled with the human cortex parcellation data presented earlier in this supplement, we aim to describe the macro-connectome of the IFOF in relation to the linked parcellations present within the human cortex. The purpose of this study is to present this information in an indexed, illustrated, and tractographically aided series of figures and tables for anatomic and clinical reference.

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