scholarly journals Using Metabolomics to Classify the Underlying Effects of Multi-Nutrient Supplementation in ADHD Youth

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1351-1351
Author(s):  
Madeline Stern ◽  
Leanna Perez ◽  
Jeanette Johnstone ◽  
Barbara Gracious ◽  
Brenda Leung ◽  
...  
Keyword(s):  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Adhd Symptoms ◽  
Open Label ◽  
Nutrient Supplementation ◽  
Open Label Phase ◽  
The Ohio State University ◽  
Double Blinded

Abstract Objectives Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric disorder commonly diagnosed in childhood. Current pharmaceutical treatment options provide a poor long-term risk: benefit ratio with little knowledge of the long-term effects. A broad-spectrum multi-nutrient formula has shown promise in children, but its effects on nutrient status and the underlying metabolome interactions have not been characterized. Methods Blood samples from medication-free children (n = 74) with ADHD enrolled in a double–blind randomized placebo-controlled multinutrient trial (RCT) were collected at baseline and 8 weeks post-intervention. Following RCT is an 8-week open label phase during which all participants took the active supplement. Symptoms were assessed using the Child and Adolescent Symptom Inventory 5. Double-blinded plasma samples will be analyzed for tyrosine, phenylalanine, tryptophan, magnesium, and zinc. Untargeted LC-MS metabolomics using HILIC chromatography and a high resolution QTof will assess very polar analytes in plasma extracts. Linear modeling will elucidate the influence of treatment, sampling time, and ADHD symptom score on plasma nutrient and plasma metabolite concentration. Results Preliminary findings of the open label phase show a significant improvement in inattention (P = 0.0435), hyperactivity (P = 0.0068), ODD (P = 0.0108) and DMDD (P = 0.0119). We hypothesize that these improvements in ADHD symptoms will be correlated with increased circulating concentrations of tyrosine, phenylalanine, tryptophan, magnesium, zinc, and metabolites involved in neurotransmitter synthesis and/or branched chain amino acid metabolism. Conclusions Preliminary findings indicate improvements of ADHD symptoms of inattention, hyperactivity, ODD and DMDD following 8 weeks of open label multi-nutrient supplementation. Results of the double-blinded phase are expected to mirror those observed in the open label phase, with increases in nutrients in those receiving the multinutrient. Funding Sources The sample analyses were supported by NIH Award Number Grant P30 CA016058, OSU, and OSUCCC. Foundation for the Center of Excellence in Mental Health, Canada; The Ohio State University Department of Human Sciences, College of Education and Human Ecology; The Ohio State University Wexner Medical Center, Clinical Research Center.

scholarly journals Multinutrients for ADHD Youth (MADDY) Trial: Preliminary Trends for Treatment (P16-028-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Madeline Stern ◽  
Leanna Perez ◽  
Jeanette Johnstone ◽  
Barbara Gracious ◽  
Brenda Leung ◽  
...  
Keyword(s):  
Alternative Treatment ◽  
Medical Center ◽  
Controlled Trial ◽  
Outcome Data ◽  
Ohio State University ◽  
State University ◽  
Adhd Symptoms ◽  
Open Label ◽  
The Ohio State University ◽  
Mood Dysregulation

Abstract Objectives Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric disorder with increasing global prevalence and high heritability commonly diagnosed in childhood. Current pharmaceutical treatment options provide a poor long-term risk: benefit ratio. Nutrition has significant effects on neurological functioning, and increasing evidence exists to support the use of multinutrients as alternative treatment for ADHD. The goal of this study is to assess the efficacy and tolerability of a multinutrient supplement as an alternative treatment for ADHD and co-occurring mood dysregulation symptoms. Methods The Multinutrients in ADHD Youth study is a fully-funded, multi-site, randomized double-blinded clinical trial for adolescents ages 6–12 years (n = 135). The study is 16 weeks in total, with an 8-week randomized controlled trial (RCT) followed by an 8-week open label (OL) phase. During the RCT phase, participants are assigned to either the treatment or placebo group at a 3:2 ratio. Study outcomes of ADHD symptoms include child's inattention, hyperactivity and mood dysregulation, which are assessed using validated questionnaires. Outcome data for the OL phase of the study were analyzed using end of RCT phase as baseline given that the RCT component of the study is still blinded. Results Preliminary findings based on the OL phase compared ADHD symptoms following 8 weeks of open label supplementation (n = 27 families). A significant decrease in symptom count was found for inattention (P ≤ 0.001), hyperactivity (P ≤ 0.001), ODD (P ≤ 0.001) and DMDD (P ≤ 0.001). Conclusions This study is the first adequately powered RCT in North America to investigate the effects of multinutrients supplements on ADHD symptoms among children. Preliminary findings indicate a trend in the improvements of ADHD symptoms of inattention, hyperactivity, ODD and DMDD in the OL phase of the study. Funding Sources Foundation for the Center of Excellence in Mental Health, Canada; The Ohio State University Department of Human Sciences, College of Education and Human Ecology; The Ohio State University Wexner Medical Center, Clinical Research Center.

Pharmacy Issues: Intravenous Drug Ordering

2001 ◽  
Vol 36 (3) ◽  
pp. 329-332
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care ◽  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
Intravenous Drug ◽  
State University ◽  
Order Entry ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University

This continuing feature will inform readers about the process of implementing, maintaining, and supporting prescriber computer order entry (PCOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of PCOE at the Medical Center.

Pharmacy Issues: Weight-Based Dosing

2001 ◽  
Vol 36 (7) ◽  
pp. 790-791
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care ◽  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Order Entry ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University

This continuing feature will inform readers about the process of implementing, maintaining, and supporting prescriber computer order entry (PCOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of PCOE at the Medical Center.

The Training Process (Part 1)

2003 ◽  
Vol 38 (1) ◽  
pp. 84-88 ◽  
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Order Entry ◽  
Training Process ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University ◽  
Computerized Prescriber Order Entry

This continuing feature will inform readers about the process of implementing, maintaining, and supporting computerized prescriber order entry (CPOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of CPOE at the Medical Center.

Neonatal Intensive Care Unit Pathway

2003 ◽  
Vol 38 (8) ◽  
pp. 794-797
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care Professionals ◽  
Neonatal Intensive Care ◽  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Order Entry ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University ◽  
Computerized Prescriber Order Entry

This continuing feature will inform readers about the process of implementing, maintaining, and supporting computerized prescriber order entry (CPOE) at the Ohio State University Medical Center. (By “pre-scribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of CPOE at the Medical Center.

Urinary Incontinence in Juvenile Female Soft-Coated Wheaten Terriers: Hospital Prevalence and Anatomic Urogenital Anomalies

2016 ◽  
Vol 52 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Jason Callard ◽  
Mary A. McLoughlin ◽  
Julie K. Byron ◽  
Dennis J. Chew
Keyword(s):  
Urinary Incontinence ◽  
Medical Center ◽  
Clinical Signs ◽  
Ohio State University ◽  
State University ◽  
Inclusion Criteria ◽  
Related Disorder ◽  
Juvenile Female ◽  
The Ohio State University ◽  
Ectopic Ureters

Urinary incontinence in juvenile female dogs is often associated with urogenital anatomic anomalies. Study objectives include: (1) determine hospital prevalence of urinary incontinence in juvenile female soft-coated wheaten terriers (SCWTs) compared to other affected dogs; (2) characterize anatomic anomalies affecting urinary incontinent juvenile female SCWTs utilizing uroendoscopy; and (3) compare incidence of ectopic ureters, paramesonephric remnants, and short urethras in juvenile female urinary incontinent SCWTs to other juvenile female dogs with urinary incontinence. We hypothesize juvenile SCWTs have an increased prevalence of urinary incontinence and an increased incidence of ectopic ureters, paramesonephric remnants, and short urethras compared to non-SCWTs with urinary incontinence within our hospital population. Medical records of female dogs 6 mo of age and younger with clinical signs of urinary incontinence and video uroendoscopic evaluation presenting to The Ohio State University Veterinary Medical Center from January 2000 to December 2011 were reviewed. Twelve juvenile SCWTs and 107 juvenile non-SCWTs met the inclusion criteria. Juvenile SCWTs were found to have an increased hospital prevalence of urinary incontinence compared to other affected breeds. Observed anomalies in SCWTs include: ectopic ureters, shortened urethras, paramesonephric remnants, and bifid vaginas. This information will help guide veterinarians in recognizing a breed-related disorder of the lower urogenital tract in SCWTs.

scholarly journals The Engineered Course of Treatment

2001 ◽  
Vol 123 (12) ◽  
pp. 44-47 ◽  
Author(s):  
Mauro Ferrari ◽  
Jun Liu
Keyword(s):  
Three Dimensional ◽  
Coronary Bypass ◽  
Therapeutic Agents ◽  
Ohio State University ◽  
State University ◽  
Valve Repair ◽  
Surgical Field ◽  
Computer Controlled ◽  
The Ohio State University

Use of nanoscale devices is helping to revolutionize medical treatment and research. The Ohio State University recently became the first place in the country where coronary bypass and mitral valve repair operations are performed by a computer controlled robot, operated by a remotely located surgeon handling joysticks and considering a three-dimensional, enlarged view of the surgical field. With the invaluable help of many associates and students, researchers have focused on two classes of objects: devices that feature nanopore membranes, and multifunctional particulates for the delivery of medical therapeutic agents. Nanomembranes may also be used as flux regulators for the long-term release of biopharmaceuticals from implanted depots. This application embodies a purely passive mass transport mode of molecules in channels that are just a few nanometers larger than the effective radii of the molecules themselves.

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