scholarly journals Intracellular Characterization of Suppressive Responses in Supragranular Pyramidal Neurons of Cat Primary Auditory Cortex In Vivo

2002 ◽  
Vol 12 (10) ◽  
pp. 1079-1091 ◽  
Author(s):  
H. Ojima
Keyword(s):  
Auditory Cortex ◽  
Pyramidal Neurons ◽  
Primary Auditory Cortex

scholarly journals Characterization of thalamocortical responses of regular-spiking and fast-spiking neurons of the mouse auditory cortex in vitro and in silico

2012 ◽  
Vol 107 (5) ◽  
pp. 1476-1488 ◽  
Author(s):  
Max L. Schiff ◽  
Alex D. Reyes
Keyword(s):  
Auditory Cortex ◽  
Pyramidal Neurons ◽  
Modulation Frequency ◽  
Primary Auditory Cortex ◽  
Cortical Inhibition ◽  
Membrane Properties ◽  
Thalamic Stimulation ◽  
Fast Spiking

We use a combination of in vitro whole cell recordings and computer simulations to characterize the cellular and synaptic properties that contribute to processing of auditory stimuli. Using a mouse thalamocortical slice preparation, we record the intrinsic membrane properties and synaptic properties of layer 3/4 regular-spiking (RS) pyramidal neurons and fast-spiking (FS) interneurons in primary auditory cortex (AI). We find that postsynaptic potentials (PSPs) evoked in FS cells are significantly larger and depress more than those evoked in RS cells after thalamic stimulation. We use these data to construct a simple computational model of the auditory thalamocortical circuit and find that the differences between FS and RS cells observed in vitro generate model behavior similar to that observed in vivo. We examine how feedforward inhibition and synaptic depression affect cortical responses to time-varying inputs that mimic sinusoidal amplitude-modulated tones. In the model, the balance of cortical inhibition and thalamic excitation evolves in a manner that depends on modulation frequency (MF) of the stimulus and determines cortical response tuning.

scholarly journals Serotonin Transporter Defect Disturbs Structure and Function of the Auditory Cortex in Mice

2021 ◽  
Vol 15 ◽  
Author(s):  
Wenlu Pan ◽  
Jing Pan ◽  
Yan Zhao ◽  
Hongzheng Zhang ◽  
Jie Tang
Keyword(s):  
Auditory Cortex ◽  
Serotonin Transporter ◽  
Cortical Neurons ◽  
Pyramidal Neurons ◽  
Frequency Tuning ◽  
Primary Auditory Cortex ◽  
Neuronal Morphology ◽  
Neuronal Connections ◽  
The Central Nervous System ◽  
And Function

Serotonin transporter (SERT) modulates the level of 5-HT and significantly affects the activity of serotonergic neurons in the central nervous system. The manipulation of SERT has lasting neurobiological and behavioral consequences, including developmental dysfunction, depression, and anxiety. Auditory disorders have been widely reported as the adverse events of these mental diseases. It is unclear how SERT impacts neuronal connections/interactions and what mechanism(s) may elicit the disruption of normal neural network functions in auditory cortex. In the present study, we report on the neuronal morphology and function of auditory cortex in SERT knockout (KO) mice. We show that the dendritic length of the fourth layer (L-IV) pyramidal neurons and the second-to-third layer (L-II/III) interneurons were reduced in the auditory cortex of the SERT KO mice. The number and density of dendritic spines of these neurons were significantly less than those of wild-type neurons. Also, the frequency-tonotopic organization of primary auditory cortex was disrupted in SERT KO mice. The auditory neurons of SERT KO mice exhibited border frequency tuning with high-intensity thresholds. These findings indicate that SERT plays a key role in development and functional maintenance of auditory cortical neurons. Auditory function should be examined when SERT is selected as a target in the treatment for psychiatric disorders.

Characterization of Auditory Evoked Potential for Different Tones in Marmoset Primary Auditory Cortex

2019 ◽  
pp. 95-101
Author(s):  
Felipe A. Araujo ◽  
Eduardo B. Jacobi ◽  
Juliana Avila-Souza ◽  
Jose F. Rodrigues ◽  
Renan C. Moioli ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Evoked Potential ◽  
Primary Auditory Cortex ◽  
Auditory Evoked Potential

scholarly journals Experience-dependent overrepresentation of ultrasonic vocalization frequencies in the rat primary auditory cortex

2013 ◽  
Vol 110 (5) ◽  
pp. 1087-1096 ◽  
Author(s):  
Heesoo Kim ◽  
Shaowen Bao
Keyword(s):  
Auditory Cortex ◽  
Large Scale ◽  
Primary Auditory Cortex ◽  
Wide Band ◽  
Ultrasonic Vocalization ◽  
Ultrasonic Vocalizations ◽  
Central Nucleus ◽  
Frequency Range ◽  
Species Specific

Cortical sensory representation is highly adaptive to the environment, and prevalent or behaviorally important stimuli are often overrepresented. One class of such stimuli is species-specific vocalizations. Rats vocalize in the ultrasonic range >30 kHz, but cortical representation of this frequency range has not been systematically examined. We recorded in vivo cortical electrophysiological responses to ultrasonic pure-tone pips, natural ultrasonic vocalizations, and pitch-shifted vocalizations to assess how rats represent this ethologically relevant frequency range. We find that nearly 40% of the primary auditory cortex (AI) represents an octave-wide band of ultrasonic vocalization frequencies (UVFs; 32–64 kHz) compared with <20% for other octave bands <32 kHz. These UVF neurons respond preferentially and reliably to ultrasonic vocalizations. The UVF overrepresentation matures in the cortex before it develops in the central nucleus of inferior colliculus, suggesting a cortical origin and corticofugal influences. Furthermore, the development of cortical UVF overrepresentation depends on early acoustic experience. These results indicate that natural sensory experience causes large-scale cortical map reorganization and improves representations of species-specific vocalizations.

scholarly journals Local Homogeneity of Tonotopic Organization in the Primary Auditory Cortex of Marmosets

2018 ◽  
Author(s):  
Huan-huan Zeng ◽  
Jun-feng Huang ◽  
Ming Chen ◽  
Yun-qing Wen ◽  
Zhi-ming Shen ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Large Scale ◽  
Frequency Tuning ◽  
Primary Auditory Cortex ◽  
Primate Species ◽  
Tonotopic Organization ◽  
Brain Structure And Function ◽  
A1 Neurons ◽  
Cortical Regions

AbstractMarmoset has emerged as a useful non-human primate species for studying the brain structure and function. Previous studies on the mouse primary auditory cortex (A1) showed that neurons with preferential frequency tuning responses are mixed within local cortical regions, despite a large-scale tonotopic organization. Here we found that frequency tuning properties of marmoset A1 neurons are highly uniform within local cortical regions. We first defined tonotopic map of A1 using intrinsic optical imaging, and then used in vivo two-photon calcium imaging of large neuronal populations to examine the tonotopic preference at the single-cell level. We found that tuning preferences of layer 2/3 neurons were highly homogeneous over hundreds of micrometers in both horizontal and vertical directions. Thus, marmoset A1 neurons are distributed in a tonotopic manner at both macro- and microscopic levels. Such organization is likely to be important for the organization of auditory circuits in the primate brain.

Characterization of time‐varying responses to dynamic broadband spectra in primary auditory cortex

2000 ◽  
Vol 107 (5) ◽  
pp. 2812-2812
Author(s):  
Jonathan Z. Simon ◽  
Didier A. Depireux ◽  
David J. Klein ◽  
Shihab A. Shamma
Keyword(s):  
Auditory Cortex ◽  
Primary Auditory Cortex ◽  
Time Varying
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