Novel Approach to Performing Metabolite Identification in Drug Metabolism

Faculty Opinions recommendation of Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734257569.793557467 ◽

2019 ◽

Author(s):

Santosh Kumar

Keyword(s):

Drug Metabolism ◽

Drug Exposure ◽

A novel approach for precisely controlled multiple cell patterning in microfluidic chips by inkjet printing and the detection of drug metabolism and diffusion

The Analyst ◽

10.1039/c6an00395h ◽

2016 ◽

Vol 141 (10) ◽

pp. 2940-2947 ◽

Cited By ~ 32

Author(s):

Jie Zhang ◽

Fengming Chen ◽

Ziyi He ◽

Yuan Ma ◽

Katsumi Uchiyama ◽

...

Keyword(s):

Drug Metabolism ◽

Inkjet Printing ◽

Cell Patterning ◽

Microfluidic Chips ◽

Cell Printing ◽

Novel Approach ◽

Multiple Cell ◽

And Diffusion

A novel platform for precise cell patterning and analysis in microchips was developed by combining inkjet cell-printing and microfluidic chips.

Faculty Opinions recommendation of Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734257569.793552446 ◽

2018 ◽

Cited By ~ 1

Author(s):

Geoffrey Tucker

Keyword(s):

Drug Metabolism ◽

Drug Exposure ◽

Ion cluster techniques in drug metabolism: An example of the use of mixtures of the [12C]:[14C] isotopic forms of the synthetic prostaglandin cloprostenol (‘Estrumate’) to Facilitate Metabolite Identification

Journal of Mass Spectrometry ◽

10.1002/bms.1200060811 ◽

1979 ◽

Vol 6 (8) ◽

pp. 359-360 ◽

Cited By ~ 6

Author(s):

G. R. Bourne ◽

S. R. Moss ◽

P. J. Phillips ◽

J. T. A. Webster ◽

D. F. White

Keyword(s):

Drug Metabolism ◽

Ion Cluster

Analytical Tools and Approaches for Metabolite Identification in Drug Metabolism

Biotransformation and Metabolite Elucidation of Xenobiotics ◽

10.1002/9780470890387.ch2 ◽

2010 ◽

pp. 79-123 ◽

Cited By ~ 1

Author(s):

Yongmei Li

Keyword(s):

Drug Metabolism ◽

Analytical Tools

Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure–Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01293 ◽

2016 ◽

Vol 59 (5) ◽

pp. 1818-1829 ◽

Cited By ~ 12

Author(s):

Ting Zhang ◽

Yong Liu ◽

Xianshu Yang ◽

Gary E. Martin ◽

Huifang Yao ◽

...

Keyword(s):

Drug Design ◽

Identification System ◽

Structure Activity Relationships ◽

Factor Ixa ◽

Structure Activity ◽

Novel Approach ◽

Ligand Identification

Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism

Journal of Chromatographic Science ◽

10.1093/chromsci/41.8.398 ◽

2003 ◽

Vol 41 (8) ◽

pp. 398-404 ◽

Cited By ~ 32

Author(s):

A.- E. F. Nassar

Keyword(s):

Liquid Chromatography ◽

Drug Metabolism ◽

Mass Spectrometer ◽

Time Of Flight ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Flight Mass Spectrometer ◽

Hydrogen Deuterium ◽

Tandem Quadrupole

Faculty Opinions recommendation of Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726140974.793529225 ◽

2017 ◽

Author(s):

Andrew Stamford

Keyword(s):

Drug Design ◽

Identification System ◽

Structure Activity Relationships ◽

Factor Ixa ◽

Structure Activity ◽

Novel Approach ◽

Ligand Identification

A Novel Approach to Predicting P450 Mediated Drug Metabolism. CYP2D6 Catalyzed N-Dealkylation Reactions and Qualitative Metabolite Predictions Using a Combined Protein and Pharmacophore Model for CYP2D6

Journal of Medicinal Chemistry ◽

10.1021/jm991058v ◽

1999 ◽

Vol 42 (20) ◽

pp. 4062-4070 ◽

Cited By ~ 101

Author(s):

Marcel J. de Groot ◽

Mark J. Ackland ◽

Valerie A. Horne ◽

Alexander A. Alex ◽

Barry C. Jones

Keyword(s):

Drug Metabolism ◽

Pharmacophore Model ◽

The Role of Drug Metabolism and Metabolite Identification in Drug Discovery

Evaluation of Drug Candidates for Preclinical Development ◽

10.1002/9780470574898.ch5 ◽

2010 ◽

pp. 109-133

Author(s):

Xiangming Guan

Keyword(s):

Drug Discovery ◽

Drug Metabolism ◽

Metabolite Identification