Coupling of Fused Deposition Modeling and Inkjet Printing to Produce Drug Loaded 3D Printed Tablets

In the current study, we have coupled Fused Deposition Modelling (FDM) for the fabrication of plain polyvinyl alcohol (PVA) tablets followed by dispensing of minoxidil ethanolic solutions using inkjet printing. The use of a drop-on-solid printing approach facilitates an accurate and reproducible process while it controls the deposition of the drug amounts. For the purpose of the study, the effect of the solvent was investigated and minoxidil ink solutions of ethanol 70% v/v (P70) or absolute ethanol (P100) were applied on the plain PVA tablets. Physicochemical characterization showed that solvent miscibility with the polymer substrate plays a key role and can lead to the formation of drug crystals on the surface or drug absorption in the polymer matrix. The produced minoxidil tablets showed sustained release profiles or initial bursts strongly affected by the solvent grade used for dispensing the required dose on drug loaded 3D printed tablets. This paradigm demonstrates that the coupling of FDM and inkjet printing technologies could be used for rapid development of personalized dosage forms.

Nickel Oxide-based Flexible Thin-Film NTC Thermistors by using reverse offset printing

In recent years, the use of printing methods to fabricate electronic devices (printed electronics) has attracted attention because of their low cost and low environmental impact. Printing technology enables the high-throughput fabrication of electrical circuits on film substrates, providing inexpensive personal healthcare devices to monitor health status in real-time. Temperature detection is one of the central concerns as a fundamental physical quantity in various fields. In 2013, a highly sensitive flexible thermistor was reported by formulating aqueous inks of nickel oxide nanoparticles for inkjet printing. However, the calcinating of the nickel oxide (NiO) layer required a high-temperature process of more than 200°C, which required expensive polyimide films with high heat resistance. It is necessary to promote further the development of low-temperature processes for printed thermistors to realize flexible NTC thermistors at low cost using printed electronics technology. In screen printing and inkjet printing, the definition of the ink pattern applied on the substrate changes due to spreading and coffee distortion phenomena, and the thickness between sensors becomes non-uniform, which is a structural consistency problem that can lead to variations in sensing performance. This study developed a printing and low-temperature calcinating method of NTC thermistors with a temperature-sensitive layer of nickel oxide by using reverse offset printing. The NTC thermistors were fabricated by printing a comb-like pattern of silver nanoparticles and a thin nickel oxide film on a glass substrate. In addition, the low-temperature formation of a nickel oxide layer by oxygen plasma treatment was investigated, and XPS was used to carry out compositional analysis of the surface. Together with the plasma-assisted calcinating, a flexible NTC thermistor formed on polyethylene terephthalate (PEN) film is demonstrated.

Simulation study of droplet formation in inkjet printing using ANSYS FLUENT

Flow simulations of jetting of inkjet drops are presented for water and ethylene glycol. In the inkjet printing process, droplet jetting behaviour is the deciding parameter for print quality. The multiphase volume of fluid (VOF) method is used because the interaction between two phases (air and liquid) is involved in the drop formation process. The commercial inkjet printer has a nozzle diameter of ∼73.2μm. In this work, a simulation model of inkjet printer nozzles with different diameters 40μm, 60μm, and 80μm are developed using ANSYS FLUENT software. It is observed that when water is taken as solvent then the stable droplets are generated at 60μm nozzle diameter till 9μs because of its low viscosity. For higher diameter, the stamen formation is observed. Ethylene glycol stable droplets are achieved at 80μm nozzle diameter till 9μs because of their high viscosity (∼10 times that of water). Along with the droplet formation, the sustainability of the droplet in the air before reaching the substrate is also important. The simulation model is an inexpensive, fast, and flexible alternative to study the ink characteristics of the real-world system without wasting resources.

Assessing the Relationships between Interdigital Geometry Quality and Inkjet Printing Parameters

Drop on demand (DoD) inkjet printing is a high precision, non-contact, and maskless additive manufacturing technique employed in producing high-precision micrometer-scaled geometries allowing free design manufacturing for flexible devices and printed electronics. A lot of studies exist regarding the ink droplet delivery from the nozzle to the substrate and the jet fluid dynamics, but the literature lacks systematic approaches dealing with the relationship between process parameters and geometrical outcome. This study investigates the influence of the main printing parameters (namely, the spacing between subsequent drops deposited on the substrate, the printing speed, and the nozzle temperature) on the accuracy of a representative geometry consisting of two interdigitated comb-shape electrodes. The study objective was achieved thanks to a proper experimental campaign developed according to Design of Experiments (DoE) methodology. The printing process performance was evaluated by suitable geometrical quantities extracted from the acquired images of the printed samples using a MATLAB algorithm. A drop spacing of 140 µm and 170 µm on the two main directions of the printing plane, with a nozzle temperature of 35 °C, resulted as the most appropriate parameter combination for printing the target geometry. No significant influence of the printing speed on the process outcomes was found, thus choosing the highest speed value within the investigated range can increase productivity.

Influence of the surface characteristics of corrugated cardboard on the quality of inkjet printing

This paper investigates the quality of inkjet printing on corrugated cardboard with various characteristics such as the presence of surface coating, the type of cardboard structure, the corrugated layer profile, and the corrugated cardboard height. The color characteristics of the corrugated board surface of studied samples were analyzed in the CIE Lab system; the value of the discrepancy in the shade of white was established when compared with the reference values of the ISO 12647 standard. During the study, the main criteria for assessing the quality of color reproduction of inkjet imprints were analyzed: an indicator of the general contrast level (K), the value of color differences for the basic tone shades (ΔE), and the volume of the body color coverage (ΔE2). It was found that when printing on various types of corrugated cardboard, there is a general decrease in the overall contrast value. The actual level of color differences is ΔE=10...45 and exceeds the permissible standards for the color reproduction quality. This adversely affects the reproduction of different color tones in the printed image. In general, the quality of color reproduction differs for the test samples of corrugated cardboard in terms of the magnitude of the spread in the values of color distortions on the tone shades. The influence of the main characteristics of the investigated samples of corrugated cardboard on the quality indicators of inkjet printing has been analyzed. In particular, a significant influence of the index of color characteristics of the surface of corrugated cardboard L* and the type of corrugated board structure on the quality of color reproduction has been established. The study results reported here could make it possible to reasonably approach the selection of the corrugated board structure that is optimal in composition, increase the productivity of the technological process for manufacturing containers, and stabilize the quality of printing on corrugated cardboard