Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism

A.- E. F. Nassar

doi:10.1093/chromsci/41.8.398

Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism

Journal of Chromatographic Science ◽

10.1093/chromsci/41.8.398 ◽

2003 ◽

Vol 41 (8) ◽

pp. 398-404 ◽

Cited By ~ 32

Author(s):

A.- E. F. Nassar

Keyword(s):

Liquid Chromatography ◽

Drug Metabolism ◽

Mass Spectrometer ◽

Time Of Flight ◽

Metabolite Identification ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Flight Mass Spectrometer ◽

Hydrogen Deuterium ◽

Tandem Quadrupole

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Increasing throughput and information content forin vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.1859 ◽

2005 ◽

Vol 19 (6) ◽

pp. 843-848 ◽

Cited By ~ 159

Author(s):

Jose Castro-Perez ◽

Robert Plumb ◽

Jennifer H. Granger ◽

Iain Beattie ◽

Karine Joncour ◽

...

Keyword(s):

Liquid Chromatography ◽

Drug Metabolism ◽

Information Content ◽

Mass Spectrometer ◽

Time Of Flight ◽

Ultra Performance Liquid Chromatography ◽

Flight Mass Spectrometer

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A simple method for differentiation of monoisotopic drug metabolites with hydrogen–deuterium exchange liquid chromatography/electrospray mass spectrometry

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2005.02.005 ◽

2005 ◽

Vol 25 (1) ◽

pp. 155-162 ◽

Cited By ~ 28

Author(s):

Ari Tolonen ◽

Miia Turpeinen ◽

Jouko Uusitalo ◽

Olavi Pelkonen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Simple Method ◽

Drug Metabolites ◽

Hydrogen Deuterium

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A new, simple, efficient and robust multi-residue method based on pressurised-liquid extraction of agricultural soils to analyze pesticides by liquid chromatography coupled with a high resolution quadrupole time-of-flight mass spectrometer

International Journal of Environmental & Analytical Chemistry ◽

10.1080/03067319.2021.1889531 ◽

2021 ◽

pp. 1-16

Author(s):

Giovanni Caria ◽

Nicolas Proix ◽

Christian Mougin ◽

Baghdad Ouddane ◽

Sopheak Net

Keyword(s):

Liquid Chromatography ◽

High Resolution ◽

Mass Spectrometer ◽

Agricultural Soils ◽

Time Of Flight ◽

Liquid Extraction ◽

Flight Mass Spectrometer ◽

Pressurised Liquid Extraction

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An efficient and comprehensive plant glycerolipids analysis approach based on high‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometer

Plant Direct ◽

10.1002/pld3.183 ◽

2019 ◽

Vol 3 (11) ◽

Cited By ~ 4

Author(s):

Shaoping Lu ◽

Hongbo Liu ◽

Cheng Jin ◽

Qing Li ◽

Liang Guo

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Mass Spectrometer ◽

High Performance ◽

Time Of Flight ◽

Analysis Approach ◽

Flight Mass Spectrometer

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Isomerization of cannabidiol and Δ9 -tetrahydrocannabinol during positive electrospray ionization. In-source hydrogen/deuterium exchange experiments by flow injection hybrid quadrupole-time-of-flight mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.6244 ◽

2012 ◽

Vol 26 (12) ◽

pp. 1407-1414 ◽

Cited By ~ 13

Author(s):

Sebastian Broecker ◽

Fritz Pragst

Keyword(s):

Mass Spectrometry ◽

Electrospray Ionization ◽

Flow Injection ◽

Time Of Flight ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Flight Mass Spectrometry ◽

Hydrogen Deuterium

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Hydrogen-deuterium exchange studies utilizing a thermospray mass spectrometer interface

Analytical Chemistry ◽

10.1021/ac00170a021 ◽

1988 ◽

Vol 60 (19) ◽

pp. 2090-2095 ◽

Cited By ~ 31

Author(s):

Marshall M. Siegel

Keyword(s):

Mass Spectrometer ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium

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Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique

Journal of Mass Spectrometry ◽

10.1002/jms.1943 ◽

2011 ◽

Vol 46 (8) ◽

pp. 725-733 ◽

Cited By ~ 23

Author(s):

Tian Liu ◽

Fuying Du ◽

Yakun Wan ◽

Fanping Zhu ◽

Jie Xing

Keyword(s):

Phase I ◽

Mass Spectrometer ◽

Rapid Identification ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hybrid Mass Spectrometer ◽

Hydrogen Deuterium ◽

Phase I And Ii ◽

Exchange Technique

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High-throughput liquid chromatography ultraviolet/mass spectrometric analysis of combinatorial libraries using an eight-channel multiplexed electrospray time-of-flight mass spectrometer

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.731 ◽

2002 ◽

Vol 16 (15) ◽

pp. 1440-1447 ◽

Cited By ~ 22

Author(s):

Liling Fang ◽

Jason Cournoyer ◽

Michael Demee ◽

Jiang Zhao ◽

Duayne Tokushige ◽

...

Keyword(s):

Liquid Chromatography ◽

Mass Spectrometer ◽

High Throughput ◽

Time Of Flight ◽

Combinatorial Libraries ◽

Mass Spectrometric ◽

Mass Spectrometric Analysis ◽

Spectrometric Analysis ◽

Flight Mass Spectrometer

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Oligonucleotide Gas-Phase Hydrogen/Deuterium Exchange with D2S in the Collision Cell of a Quadrupole-Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

Analytical Chemistry ◽

10.1021/ac0713095 ◽

2007 ◽

Vol 79 (20) ◽

pp. 7893-7898 ◽

Cited By ~ 7

Author(s):

Jingjie Mo ◽

Kristina Håkansson

Keyword(s):

Fourier Transform ◽

Gas Phase ◽

Mass Spectrometer ◽

Cyclotron Resonance ◽

Deuterium Exchange ◽

Collision Cell ◽

Ion Cyclotron Resonance ◽

Hydrogen Deuterium Exchange ◽

Ion Cyclotron ◽

Hydrogen Deuterium

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Structural characterization of pregnane glycosides from Cynanchum auriculatum by liquid chromatography on a hybrid ion trap time-of-flight mass spectrometer

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.4125 ◽

2009 ◽

Vol 23 (14) ◽

pp. 2151-2160 ◽

Cited By ~ 13

Author(s):

Lian-Wen Qi ◽

Xiao-Jie Gu ◽

Ping Li ◽

Yan Liang ◽

Haiping Hao ◽

...

Keyword(s):

Liquid Chromatography ◽

Mass Spectrometer ◽

Structural Characterization ◽

Ion Trap ◽

Time Of Flight ◽

Flight Mass Spectrometer ◽

Cynanchum Auriculatum

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