Analytical Tools and Approaches for Metabolite Identification in Drug Metabolism

2010 ◽  
pp. 79-123 ◽  
Author(s):  
Yongmei Li
Keyword(s):  
Drug Metabolism ◽  
Metabolite Identification ◽  
Analytical Tools

Analytical Tools and Approaches for Metabolite Identification in Early Drug Discovery

2006 ◽  
Vol 24 (2) ◽  
pp. 248-257 ◽  
Author(s):  
Yuan Chen ◽  
Mario Monshouwer ◽  
William L. Fitch
Keyword(s):  
Drug Discovery ◽  
Metabolite Identification ◽  
Analytical Tools ◽  
Early Drug

In situ TEM studies of irradiation effects for materials improvement

1991 ◽  
Vol 49 ◽  
pp. 452-453
Author(s):  
Charles W. Allen
Keyword(s):  
Nuclear Reactor ◽  
Austenitic Stainless Steels ◽  
High Energy ◽  
Point Of View ◽  
In Situ Tem ◽  
Irradiation Effects ◽  
Tem Analysis ◽  
Radiation Induced ◽  
Analytical Tools

Irradiation effects studies employing TEMs as analytical tools have been conducted for almost as many years as materials people have done TEM, motivated largely by materials needs for nuclear reactor development. Such studies have focussed on the behavior both of nuclear fuels and of materials for other reactor components which are subjected to radiation-induced degradation. Especially in the 1950s and 60s, post-irradiation TEM analysis may have been coupled to in situ (in reactor or in pile) experiments (e.g., irradiation-induced creep experiments of austenitic stainless steels). Although necessary from a technological point of view, such experiments are difficult to instrument (measure strain dynamically, e.g.) and control (temperature, e.g.) and require months or even years to perform in a nuclear reactor or in a spallation neutron source. Consequently, methods were sought for simulation of neutroninduced radiation damage of materials, the simulations employing other forms of radiation; in the case of metals and alloys, high energy electrons and high energy ions.

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