scholarly journals Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry for Analysis of in Vivo and in Vitro Metabolites of Scopolamine in Rats

2008 ◽  
Vol 46 (1) ◽  
pp. 74-80 ◽  
Author(s):  
H. Chen ◽  
Y. Chen ◽  
P. Du ◽  
F. Han
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Electrospray Ionization ◽  
Ion Trap ◽  
Ion Trap Mass Spectrometry

Identification and characterization of in vitro, in vivo, and reactive metabolites of tandutinib using liquid chromatography ion trap mass spectrometry

2021 ◽  
Author(s):  
Nasser S. Al-Shakliah ◽  
Mohamed W. Attwa ◽  
Haitham AlRabiah ◽  
Adnan A. Kadi
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ion Trap ◽  
Reactive Metabolites ◽  
Ion Trap Mass Spectrometry ◽  
Identification And Characterization

Ten metabolites and five cyano adducts of TND were characterized using LC-ITMS. All metabolic and bioactivation reactions occurred at the N-piperidine and piperazine groups, which were predicted to be responsible for the TND toxicity and instability.

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