scholarly journals Development and Validation of a Rapid Liquid Chromatographic Method for the Determination of Oxatomide and Its Related Impurities

2014 ◽  
Vol 52 (10) ◽  
pp. 1267-1272 ◽  
Author(s):  
Laura Curtin Whelan ◽  
Michael Geary ◽  
Paul Sweetman
Keyword(s):  
Chromatographic Method ◽  
Related Impurities ◽  
Liquid Chromatographic Method ◽  
Development And Validation ◽  
Liquid Chromatographic

scholarly journals Development and Validation of a Liquid Chromatographic Method for the Simultaneous Determination of Estradiol, Estriol, Estrone, and Progesterone in Pharmaceutical Preparations

2009 ◽  
Vol 92 (3) ◽  
pp. 846-854 ◽  
Author(s):  
Phyllis Wilson
Keyword(s):  
Mobile Phase ◽  
Chromatographic Method ◽  
Pharmaceutical Preparations ◽  
Men And Women ◽  
Naturally Occurring ◽  
Vital Functions ◽  
Liquid Chromatographic Method ◽  
Development And Validation ◽  
Liquid Chromatographic

Abstract Progesterone and estrogens are hormones produced in the human body that are essential for regulating many vital functions. The three major estrogens produced by women are estriol, estradiol, and estrone. Progesterone is a naturally occurring hormone in both men and women. Pharmaceuticals containing estrogens alone or estrogens in combination with progesterone are commonly used in therapy. Patients requiring unique combinations of the drugs rely on pharmacies to compound the ingredients. In order to assess the potency of drugs containing combinations of estrogens and progesterone, a method was developed to determine all four ingredients simultaneously. The liquid chromatographic method utilized a Bondapak C18 column with an isocratic mobile phase of acetonitrilewater (50 + 50, v/v) at a flow rate of 1.0 mL/min and temperature of 30C. Under these conditions, the order of elution was estriol, estradiol, and estrone, followed by progesterone. UV detection was at 205 nm to monitor elution of the estrogens, then switched to 270 nm to monitor progesterone. The method was applied to the analysis of pharmacy-compounded drugs containing combinations of the hormones. Validation studies demonstrated that the method is accurate and precise.

scholarly journals Development and validation of a High Performance Liquid Chromatographic method for determination of etoposide in biodegradable polymeric implants

Química Nova ◽  
2012 ◽  
Vol 35 (6) ◽  
pp. 1239-1243 ◽  
Author(s):  
Ana Gabriela Reis Solano ◽  
Gisele Rodrigues da Silva ◽  
Silvia Ligório Fialho ◽  
Armando da Silva Cunha Júnior ◽  
Gérson Antônio Pianetti
Keyword(s):  
High Performance ◽  
Chromatographic Method ◽  
High Performance Liquid Chromatographic ◽  
Liquid Chromatographic Method ◽  
Polymeric Implants ◽  
Development And Validation ◽  
Liquid Chromatographic
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