Editorial Commentary: Antifungal Therapeutic Drug Monitoring Progress: Getting It Right the First Time

Therapeutic drug monitoring (TDM) has consistently been shown to be useful for optimization of drug therapy. For the first time, a method has been developed for the text analysis of TDM in SPCs in that a catalogue SPC-ContentTDM (SPCCTDM) provides a codification of the content of TDM in SPCs. It consists of six structure-related items (dose, adverse drug reactions, drug interactions, overdose, pregnancy/breast feeding, and pharmacokinetics) according to implicit or explicit references to TDM in paragraphs of the SPC, and four theory-guided items according to the information about ranges of plasma concentrations and a recommendation of TDM in the SPC. The catalogue is regarded as valid for the text analysis of SPCs with respect to TDM. It can be used in the comparison of SPCs, in the comparison with medico-scientific evidence and for the estimation of the perception of TDM in SPCs by the reader. Regarding the approach as a model of text mining, it may be extended for evaluation of other aspects reported in SPCs.

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SPCCTDM, a Catalogue for Analysis of Therapeutic Drug Monitoring Related Contents in the Drug Prescription Information

International Journal of Knowledge Discovery in Bioinformatics ◽

10.4018/jkdb.2010040101 ◽

2010 ◽

Vol 1 (2) ◽

pp. 1-11

Author(s):

Sven Ulrich ◽

Pierre Baumann ◽

Andreas Conca ◽

Hans-Joachim Kuss ◽

Viktoria Stieffenhofer ◽

...

Keyword(s):

Drug Therapy ◽

Therapeutic Drug Monitoring ◽

Drug Monitoring ◽

Text Analysis ◽

Scientific Evidence ◽

Drug Prescription ◽

Plasma Concentrations ◽

Therapeutic Drug ◽

Drug Reactions ◽

First Time

Therapeutic drug monitoring (TDM) has consistently been shown to be useful for optimization of drug therapy. For the first time, a method has been developed for the text analysis of TDM in SPCs in that a catalogue SPC-ContentTDM (SPCCTDM) provides a codification of the content of TDM in SPCs. It consists of six structure-related items (dose, adverse drug reactions, drug interactions, overdose, pregnancy/breast feeding, and pharmacokinetics) according to implicit or explicit references to TDM in paragraphs of the SPC, and four theory-guided items according to the information about ranges of plasma concentrations and a recommendation of TDM in the SPC. The catalogue is regarded as valid for the text analysis of SPCs with respect to TDM. It can be used in the comparison of SPCs, in the comparison with medico-scientific evidence and for the estimation of the perception of TDM in SPCs by the reader. Regarding the approach as a model of text mining, it may be extended for evaluation of other aspects reported in SPCs.

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Saliva versus Plasma Therapeutic Drug Monitoring of Pregabalin in Jordanian Patients

Drug Research ◽

10.1055/a-0600-2113 ◽

2018 ◽

Vol 68 (10) ◽

pp. 596-600 ◽

Cited By ~ 4

Author(s):

Nasir Idkaidek ◽

Salim Hamadi ◽

Manal El-Assi ◽

Ahmad Al-Shalalfeh ◽

Ahmad Al-Ghazawi

Keyword(s):

Therapeutic Drug Monitoring ◽

Women Elderly ◽

Drug Monitoring ◽

Good Alternative ◽

Therapeutic Drug ◽

P Value ◽

Two Samples ◽

Significant Difference ◽

Class 1 ◽

First Time

AbstractThe objective is using saliva instead of plasma for pregabalin therapeutic drug monitoring (TDM) since saliva reflects the free non–protein bound drug concentration, simple and noninvasive sampling, cheaper and does not require the expertise of drawing blood. Forty four patients participated in this study, two samples of saliva and another two of blood were taken from each patient; first sample of both saliva and blood is the trough sample and was taken just before the first dose of the day and second sample is the peak sample and was taken 1 h after taking the first dose of the day. Descriptive statistics and t-testing after log transformation were done using Excel, p-value=0.05 was adopted for significant difference. Optimized effective intestinal permeability of pregabalin was estimated by PK-Sim program version 7. This study for the first time revealed that pregabalin is excreted in saliva and classified as class 1 based on Salivary Excretion Classification System (SECS). A good correlation of 0.71-0.83 between Cmin and Cmax of plasma and saliva pregabalin was observed respectively which indicate that saliva sampling is a good alternative matrix for pregabalin TDM. C/D-ratios were calculated to demonstrate pharmacokinetic variability of Pregabalin; the results showed that C/D-ratio was higher in women, elderly and in those patients who had Scr.≥0.9 mg/dl. Proposed pregabalin therapeutic ranges are 0.7 to 1.84 µg/ml in plasma and 0.055 to 0.145 µg/ml in saliva, for neuropathic pain, diabetic neuropathy and disc prolapse patients.

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Editorial Commentary: Fluconazole Therapeutic Drug Monitoring in Children With Cancer: Not Today

Clinical Infectious Diseases ◽

10.1093/cid/ciu661 ◽

2014 ◽

Vol 59 (11) ◽

pp. 1534-1536 ◽

Cited By ~ 1

Author(s):

M. Cohen-Wolkowiez ◽

D. K. Benjamin

Keyword(s):

Therapeutic Drug Monitoring ◽

Drug Monitoring ◽

Therapeutic Drug ◽

Children With Cancer ◽

Editorial Commentary

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PKP-026 Therapeutic drug monitoring of vancomycin and evolution of renal function in patients with first time prosthesis replacement

European Journal of Hospital Pharmacy ◽

10.1136/ejhpharm-2016-000875.429 ◽

2016 ◽

Vol 23 (Suppl 1) ◽

pp. A190.1-A190

Author(s):

M Marín-Casino ◽

N Carballo Martínez ◽

M De Antonio Cuscó ◽

S Herrera Fernández ◽

E Esteve Palau ◽

...

Keyword(s):

Renal Function ◽

Therapeutic Drug Monitoring ◽

Drug Monitoring ◽

Therapeutic Drug ◽

Prosthesis Replacement ◽

First Time

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Diagnose und Monitoring bei chronisch-entzündlicher Darmerkrankung

Therapeutische Umschau ◽

10.1024/0040-5930/a001002 ◽

2018 ◽

Vol 75 (5) ◽

pp. 316-328

Author(s):

Christian Ansprenger ◽

Emanuel Burri

Keyword(s):

Therapeutic Drug Monitoring ◽

Drug Monitoring ◽

Morbus Crohn ◽

Therapeutic Drug ◽

Körperliche Untersuchung

Zusammenfassung. Die Diagnose und auch die Überwachung von chronisch entzündlichen Darmerkrankungen ruht auf mehreren Säulen: Anamnese, körperliche Untersuchung, Laborwerte (im Blut und Stuhl), Endoskopie, Histologie und Bildgebung. Die Diagnose kann nicht anhand eines einzelnen Befundes gestellt werden. In den letzten Jahren hat sich das Therapieziel weg von klinischen Endpunkten hin zu endoskopischen und sogar histologischen Endpunkten entwickelt. Für einige dieser neuen Therapieziele existiert allerdings noch keine allgemein gültige Definition. Regelmässige Endoskopien werden von Patienten schlecht toleriert, weshalb Surrogat-Marker wie Calprotectin untersucht wurden und eine gute Korrelation mit der mukosalen Entzündungsaktivität nachgewiesen werden konnte. Entsprechend zeigte sich bei Morbus Crohn eine Algorithmus-basierte Therapiesteuerung – unter anderem basierend auf Calprotectin – einer konventionellen Therapiesteuerung überlegen. Die Überwachung der medikamentösen Therapie («Therapeutic Drug Monitoring» [TDM]) ist ein zweites Standbein des Monitoring von chronisch entzündlichen Darmerkrankungen. Mit zunehmendem Einsatz vor allem der Biologika-Therapien wurden sowohl reaktives TDM (in Patienten mit klinischem Rezidiv) als auch proaktives TDM (in Patienten in Remission / stabiler Erkrankung) untersucht und haben (teilweise) Eingang in aktuelle Richtlinien gefunden. Zukünftige Studien werden die vorgeschlagenen Therapieziele besser definieren und den Nutzen der medikamentösen Therapieüberwachung auf den Krankheitsverlauf weiter untersuchen müssen.

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