Does Empirical Clostridium difficile Infection (CDI) Therapy Result in False-Negative CDI Diagnostic Test Results?

BackgroundThere has been interest in using the non-invasive, home-based quantitative faecal immunochemical test (FIT) to rule out colorectal cancer (CRC) in high-risk symptomatic patients.AimTo elicit public preferences for FIT versus colonoscopy (CC) and its delivery in primary care.Design & settingA cross-sectional online survey in England.MethodA total of 1057 adults (without CRC symptoms and diagnosis) aged 40–59 years were invited from an English online survey panel. Responders were asked to imagine they had been experiencing CRC symptoms that would qualify them for a diagnostic test. Participants were presented with choices between CC and FIT in ascending order of number of CRCs missed by FIT (from 1–10%). It was measured at what number of missed CRCs responders preferred CC over FIT.ResultsWhile 150 participants did not want either of the tests when both missed 1% CRCs, the majority (n = 741, 70.0%) preferred FIT to CC at that level of accuracy. However, this preference reduced to 427 (40.4%) when FIT missed one additional cancer. Women were more likely to tolerate missing CRC when using FIT. Having lower numeracy and perceiving a higher level of risk meant participants were less likely to tolerate a false negative test. Most of those who chose FIT preferred to return it by mail (62.2%), to be informed about normal test results by letter (42.1%), and about abnormal test results face to face (32.5%).ConclusionWhile the majority of participants preferred FIT over CC when both tests had the same sensitivity, tolerance for missed CRCs was low.

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Interpretation of Quick Test Results in Clostridium difficile Infection

Japanese Journal of Infection Prevention and Control ◽

10.4058/jsei.29.203 ◽

2014 ◽

Vol 29 (3) ◽

pp. 203-206 ◽

Cited By ~ 1

Author(s):

Atsuko HORIKOSHI

Keyword(s):

Clostridium Difficile ◽

Clostridium Difficile Infection ◽

Test Results ◽

Quick Test

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Diagnosis ofClostridium difficileassociated diarrhea: comparison of three rapid methods employing different markers for detection

Canadian Journal of Microbiology ◽

10.1139/m95-011 ◽

1995 ◽

Vol 41 (1) ◽

pp. 88-91 ◽

Cited By ~ 4

Author(s):

Kathleen M. Riederer ◽

Patrick Lawson ◽

Marilyn S. Held ◽

Karen Petrylka ◽

Laurence E. Briski ◽

...

Keyword(s):

Clostridium Difficile ◽

False Negative ◽

Latex Agglutination ◽

Cytotoxicity Assay ◽

Test Results ◽

Negative Results ◽

False Negative Results ◽

Hands On ◽

Rapid Tests ◽

Clostridium Difficile Associated Diarrhea

Latex agglutination and the enzyme immunoassays Cytoclone (EIA-C) and VIDAS (EIA-V) were compared with a cytotoxicity assay for the diagnosis of Clostridium difficile associated diarrhea. Among patients with discrepant results, the cytotoxicity assay and clinical assessment were used to evaluate the performance of the latex agglutination and EIA tests. Clostridium difficile associated diarrhea was documented in 30/149 samples (20.1%) from 130 patients. All test results matched in 113 instances. Latex agglutination, EIA-C, and EIA-V yielded false positive results in 10, 4, and 7 samples and false negative results in 8, 9, and 14 samples, respectively. Latex agglutination demonstrated 87.8% efficiency compared with 91.3% for EIA-C and 85.7% for EIA-V and 3 min hands-on time compared with 4.5 min for EIA-V and 10 min for EIA-C. On the basis of these findings and given the fact that all rapid tests have their shortcomings, we believe that latex agglutination is the most practical method.Key words: Clostridium difficile, diarrhea, colitis.

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IDENTIFIKASI MISKONSEPSI MENGGUNAKAN TES DIAGNOSTIK THREE-TIER PADA HUKUM NEWTON DAN PENERAPANNYA

Journal of Teaching and Learning Physics ◽

10.15575/jotalp.v1i1.3438 ◽

2019 ◽

Vol 1 (1) ◽

pp. 24-33

Author(s):

Anna Shalihah ◽

Diah Mulhayatiah ◽

Fathiah Alatas

Keyword(s):

Diagnostic Test ◽

False Positive ◽

Research Method ◽

False Negative ◽

Test Results ◽

Implementation Phase ◽

Legal Principles ◽

Newton's Law ◽

Newton’S Law ◽

Two Stages

This research aims to identify misconceptions that occur in Newton's law and its application based on diagnostic test results of students of class X SMAN 6 Tangerang Selatan and show sub concepts that experienced the highest misconceptions and low. The research was conducted in October 2015 - January 2016. The research method used is descriptive-quantitative. This study was conducted in two stages: stage manufacture of instruments held in SMAN 6 and 4 Tangerang Selatan and the implementation phase of the research conducted at SMAN 6 Tangerang Selatan. The instrument used is a three-tier diagnostic test. Results obtained 20 questions about the making of a valid with validity 0.64 and reliability 0.78. Results of the discussion showed misconception that occurred at 32.50% with a false positive at 20.97% and false negative amounting to 11.67% and misconceptions highest in subconcepts legal principles III Newton with a percentage of 56.92% and the lowest in the subconcepts variety of force with a percentage of 24.08%.

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Outcomes of Clostridium difficile Infection by Diagnostic Test in Inflammatory Bowel Disease

The American Journal of Gastroenterology ◽

10.14309/00000434-201710001-00650 ◽

2017 ◽

Vol 112 ◽

pp. S360

Author(s):

Alexander N. Levy ◽

Rachel Ackerman ◽

Bradley Gardiner ◽

Michael W. Winter ◽

David Snydman

Keyword(s):

Inflammatory Bowel Disease ◽

Clostridium Difficile ◽

Diagnostic Test ◽

Clostridium Difficile Infection ◽

Bowel Disease ◽

Inflammatory Bowel

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Suboptimal Biological Sampling as a Probable Cause of False-Negative COVID-19 Diagnostic Test Results

The Journal of Infectious Diseases ◽

10.1093/infdis/jiaa370 ◽

2020 ◽

Vol 222 (6) ◽

pp. 899-902 ◽

Cited By ~ 12

Author(s):

Natalie N Kinloch ◽

Gordon Ritchie ◽

Chanson J Brumme ◽

Winnie Dong ◽

Weiyan Dong ◽

...

Keyword(s):

Diagnostic Test ◽

False Negative ◽

Test Results ◽

Public Health Response ◽

Human Dna ◽

Health Response ◽

Proper Training ◽

Biological Sampling ◽

Polymerase Chain ◽

Digital Polymerase Chain Reaction

Abstract False-negative severe acute respiratory syndrome coronavirus 2 test results can negatively impact the clinical and public health response to coronavirus disease 2019 (COVID-19). We used droplet digital polymerase chain reaction (ddPCR) to demonstrate that human DNA levels, a stable molecular marker of sampling quality, were significantly lower in samples from 40 confirmed or suspected COVID-19 cases that yielded negative diagnostic test results (ie, suspected false-negative test results) compared with a representative pool of 87 specimens submitted for COVID-19 testing. Our results support suboptimal biological sampling as a contributor to false-negative COVID-19 test results and underscore the importance of proper training and technique in the collection of nasopharyngeal specimens.

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