scholarly journals The Impact of Human Immunodeficiency Virus Exposure on Respiratory Syncytial Virus–associated Severe Respiratory Illness in South African Infants, 2011–2016

2019 ◽  
Vol 69 (12) ◽  
pp. 2208-2211
Author(s):  
Meredith L McMorrow ◽  
Stefano Tempia ◽  
Sibongile Walaza ◽  
Florette K Treurnicht ◽  
Jocelyn Moyes ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Respiratory Syncytial Virus ◽  
South African ◽  
Respiratory Illness ◽  
Immunodeficiency Virus ◽  
Birth Dose ◽  
Virus Exposure ◽  
Syncytial Virus ◽  
The Impact ◽  
Severe Respiratory Illness

Abstract From 2011 through 2016, we conducted surveillance for severe respiratory illness in infants. Human immunodeficiency virus exposure significantly increased the risk of respiratory syncytial virus (RSV)–associated hospitalization in infants aged <5 months. More than 60% of RSV-associated hospitalizations occurred in the first 4 months of life and may be preventable through maternal vaccination or birth-dose monoclonal antibody.

scholarly journals The Impact of Maternal Human Immunodeficiency Virus Infection on the Burden of Respiratory Syncytial Virus Among Pregnant Women and Their Infants, Western Kenya

2020 ◽  
Author(s):  
Bryan O Nyawanda ◽  
Nancy A Otieno ◽  
Michael O Otieno ◽  
Gideon O Emukule ◽  
Godfrey Bigogo ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Respiratory Syncytial Virus ◽  
Hiv Infection ◽  
Pregnant Women ◽  
Respiratory Illness ◽  
Western Kenya ◽  
Immunodeficiency Virus ◽  
Maternal Hiv ◽  
Syncytial Virus ◽  
The Impact

Abstract Background Respiratory syncytial virus (RSV) is an important cause of respiratory illness worldwide; however, burden data on mother–infant pairs remain sparse in sub-Saharan Africa, where human immunodeficiency virus (HIV) is prevalent. We evaluated the impact of maternal HIV infection on the burden of RSV among mothers and their infants in western Kenya. Methods We enrolled pregnant women (≤20 weeks’ gestation) and followed them and their newborns weekly for up to 3–6 months postpartum, to document cases of acute respiratory illness (ARI). Nasal/oropharyngeal swabs were collected and tested for RSV using polymerase chain reaction. Analyses were stratified by maternal HIV status and incidence was computed per 1000 person-months. Results Compared to RSV-negative ARI cases, RSV-positive cases were associated with cough, apnea, and hospitalization among infants. RSV incidence per 1000 person-months among mothers was 4.0 (95% confidence interval [CI], 3.2–4.4), and was twice that among the HIV-infected mothers (8.4 [95% CI, 5.7–12.0]) compared to the HIV-uninfected mothers (3.1 [95% CI, 2.3–4.0]). Among infants, incidence per 1000 person-months was 15.4 (95% CI, 12.5–18.8); incidence did not differ by HIV exposure or prematurity. Conclusions HIV infection may increase the risk of RSV illness among pregnant women. Future maternal RSV vaccines may have added benefit in areas with high HIV prevalence.

Respiratory syncytial virus infection in human immunodeficiency virus-infected children

1990 ◽  
Vol 117 (2) ◽  
pp. 251-254 ◽  
Author(s):  
Sulachni Chandwani ◽  
William Borkowsky ◽  
Keith Krasinski ◽  
Robert Lawrence ◽  
Robert Welliver
Keyword(s):  
Human Immunodeficiency Virus ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Immunodeficiency Virus ◽  
Syncytial Virus
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