Increased β-N-Acetyl-Glucosaminidase Activity in Diabetes Mellitus

1974 ◽  
Vol 20 (9) ◽  
pp. 1229-1230 ◽  
Author(s):  
Francesco Belfiore ◽  
Luigi Lo Vecchio ◽  
Elena Napoli ◽  
Vito Borzi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Urinary Excretion ◽  
Lysosomal Enzymes ◽  
Renal Excretion ◽  
Control Subjects ◽  
Enhanced Activity ◽  
Blood Glucose Concentrations

Abstract In 45 diabetics the 24-h urinary excretion of β-N-acetylglucosaminidase (E.C. 3.2.1.30) was increased by 40% (P < 0.05) compared to 35 control subjects. The enzyme excretion was correlated with glycemia (r = 0.58, P < 0.001), being little changed in diabetics with blood glucose concentrations of less than 200 mg/dl, and markedly elevated (+ 123%, P < 0.001) in those whose blood glucose was greater than 200 mg/dl. The rate of diuresis seemed to have no effect. These data indicate that the enhanced activity previously described in sera of diabetics for β-N-acetyl-glucosaminidase (as well as for other lysosomal enzymes) cannot be attributed to impairment of renal excretion, and support the hypothesis that in diabetes there is an "activation" of lysosomal enzymes in tissues that causes an increase in their activity in serum and, consequently, in urine.

The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Arina D. Puspitasari ◽  
Hayu Kusuma ◽  
Dinda M.N. Ratri ◽  
Cahyo Wibisono ◽  
Budi Suprapti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Postprandial Blood Glucose ◽  
Premixed Insulin ◽  
Acting Insulin ◽  
Blood Glucose Concentrations

AbstractBackgroundOne of the therapies used to treat type 2 diabetes mellitus (T2DM) disease is combination insulin which consists of rapid-acting insulin and intermediate-acting insulin (premixed). This study aimed to examine the profile of premixed insulin related to blood glucose concentration and to identify the drug interactions due to the combination of premixed insulin with other drugs taken by T2DM patients.MethodsThis study was a prospective observational study with cross-sectional data that were analyzed descriptively. The respondents invited were T2DM patients with or without complication or comorbid disease who received premixed insulin with or without a combination of oral antidiabetic therapy in the Outpatient Unit of Universitas Airlangga Hospital, Surabaya. The research instruments used are data sheet, patient medical record, and fasting and postprandial blood glucose concentration.ResultsA total of 118 patients received premixed insulin therapy, but only 80 patients were included in the inclusion criteria. Based on types of insulin, the combination of 30% aspart and 70% protamine aspart was used by 91.25% T2DM patients, and a combination of 25% insulin lispro and 75% protamine lispro was used by 8.75% T2DM patients. There were 30.3% of patients who could achieve the target of 80–130 mg/dL in fasting blood glucose concentrations, and 35.1% of patients achieved the target of ≤180 mg/dL in postprandial blood glucose concentration. Drug interactions may occur in patients who use premixed insulin with glimepiride, lisinopril, fenofibrate, candesartan, irbesartan, and gemfibrozil.ConclusionsIn this study, premixed insulin have not reached the target of fasting and postprandial blood glucose concentrations in most patients.

scholarly journals Effect of Control of Blood Glucose on Urinary Excretion of N-acetyl-β -D-glucosaminidase in Elderly -Type 2 Diabetes Mellitus-

2000 ◽  
Vol 67 (2) ◽  
pp. 143-145 ◽  
Author(s):  
Kenzo Oba ◽  
Yoshimasa Igari ◽  
Noriaki Matsumura ◽  
Kentaro Watanabe ◽  
Yuki Inuzuka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Urinary Excretion

Amino Acids as Substrates in Children with Growth Hormone Deficiency and Hypoglycemia

PEDIATRICS ◽  
1981 ◽  
Vol 68 (2) ◽  
pp. 260-264
Author(s):  
Stephen LaFranchi ◽  
Neil R. M. Buist ◽  
Banoo Jhaveri ◽  
Harvey Klevit
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Human Growth ◽  
Hormone Deficiency ◽  
Total Serum ◽  
Control Subjects ◽  
Fasting Hypoglycemia ◽  
Blood Glucose Concentrations

In order to investigate the role of amino acid (AA) substrates in the hypoglycemia associated with human growth hormone (hGH) deficiency, we measured 12-hour fasting blood glucose and total quantitative AA concentrations in 11 children with hGH deficiency during three study periods: (1) before hGH replacement; (2) after 12 months of hGH treatment; and (3) after discontinuation of hGH for three months. The results were compared to studies in 16 control subjects. Fasting blood glucose concentrations were significantly (P < .05) lower in the hGH-deficient children prior to hGH treatment as compared to the control subjects (67.0 ± 5.3 vs 80.7 ± 5.3 mg/100 ml, X ± SE). Fasting total serum AA concentrations were similar in the patients and in the control subjects; however, after 12 months of hGH replacement, there was a significant (P < .01) elevation of serum AA (2,750 ± 170 vs 2,283 µmoles/liter). Fasting serum concentrations of alanine, glycine, arginine, and tryptophan were also significantly elevated (P < .01) with hGH treatment; ornithine, tyrosine, lysine, methionine, and phenylalanine showed lesser elevations (P < .05), whereas threonine decreased significantly (P < .01). The fasting hypoglycemia seen with isolated hGH deficiency is not an AA substrate-limited disorder. The finding of increased concentrations of AA with hGH replacement suggests increased retention of nitrogen and synthesis of AA or a decreased requirement of AA for gluconeogenesis due to availability of other substrates.

Home-monitoring of blood glucose in cats with diabetes mellitus: Evaluation over a 4-month period

2005 ◽  
Vol 7 (3) ◽  
pp. 163-171 ◽  
Author(s):  
Martina Casella ◽  
Mike Hässig ◽  
Caudia E. Reusch
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Food Intake ◽  
Negative Pressure ◽  
Home Monitoring ◽  
Glucose Levels ◽  
Lower Glucose ◽  
Blood Glucose Concentrations ◽  
At Home

Home-monitoring of blood glucose concentrations has recently been introduced to owners. The objectives of this study were to investigate the feasibility of home-monitoring of blood glucose in diabetic cats by owners, the problems encountered and to compare glucose concentrations at home with those measured in the hospital. Twelve of 15 cat owners were able to generate glucose curves over the study period of 4 months. Most problems were related to restraining the cat, generating negative pressure with the lancing device and producing a blood drop. In the majority of cases, these problems could be resolved during the study. Blood glucose concentrations in the clinic tended to be lower than at home; some of the differences were significant. No association between tolerance of the procedure and blood glucose concentrations measured at home was found. We, therefore, assume that the lower glucose levels in the hospital were caused by lack of food intake. In 38% of cases, treatment based on hospital curves would have been different from that based on home curves. Home-monitoring appears to be a valuable tool in the management of cats with diabetes mellitus. One of its major advantages is that it enables frequent generation of blood glucose curves, which is of particular importance in cats that are difficult to regulate.

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