Gas--liquid chromatographic microdetermination of underivatized ethosuximide (alpha-ethyl-alpha-methyl succinimide) in plasma or serum.
1978 ◽
Vol 24
(10)
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pp. 1821-1823
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Keyword(s):
Abstract A gas-liquid chromatographic procedure for the microdetermination of ethosuximide is described. Ethosuximide is extracted from acidified plasma or serum into chloroform containing an internal standard alpha,alpha-dimethyl-beta-methyl succinimide. Part of the initial chloroform extract is gently evaporated, the residue redissolved in n-heptane at 60 degrees C, and an aliquot analyzed by gas-liquid chromatography. The procedure is rapid, reliable, sensitive, and specific. It requires a 25--50 microliter sample for a single estimation, has a detection threshold of less than 10 micromol/liter, and is suitable for routine clinical use.
1982 ◽
Vol 65
(6)
◽
pp. 1388-1394
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1968 ◽
Vol 46
(4)
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pp. 665-667
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2004 ◽
Vol 42
(2)
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1977 ◽
Vol 60
(4)
◽
pp. 935-939
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