Idiopathic hemochromatosis: serum ferritin concentrations during therapy by phlebotomy.

1982 ◽  
Vol 28 (8) ◽  
pp. 1806-1808 ◽  
Author(s):  
P J Garry ◽  
J H Saiki
Keyword(s):  
Serum Ferritin ◽  
Iron Absorption ◽  
Binding Capacity ◽  
Hemoglobin Concentration ◽  
Total Iron ◽  
Ferritin Iron ◽  
Idiopathic Hemochromatosis ◽  
Total Body ◽  
Almost All ◽  
Iron Binding Capacity

Abstract We report the case of a 54-year-old man who presented with symptoms of idiopathic hemochromatosis, an inherited disorder involving regulation of iron absorption. These symptoms usually do not appear until total body iron content reaches 15 g, about threefold normal. Therapy involves mobilization and removal of excess stored iron through weekly or twice-weekly phlebotomies of 500 mL, until the hemoglobin concentration becomes less than 110 g/L and remains there for several weeks, or until serum ferritin concentrations indicate that almost all the stored iron has been removed (ferritin less than 12 micrograms/L). Here, concentrations of ferritin in serum were used as an index to iron overload and removal of stored iron. We report changes in hemoglobin, serum ferritin, iron, and total iron-binding capacity during the course of removing by phlebotomy more than 20 g of iron from a patient with idiopathic hemochromatosis.

Serum Ferritin and Total Iron-Binding Capacity to Estimate Iron Storage in Pigs

1984 ◽  
Vol 21 (6) ◽  
pp. 597-600 ◽  
Author(s):  
J. E. Smith ◽  
K. Moore ◽  
D. Boyington ◽  
D. S. Pollmann ◽  
D. Schoneweis
Keyword(s):  
Serum Ferritin ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Storage ◽  
Iron Binding Capacity

Serum iron and total iron-binding capacity compared with serum ferritin in assessment of iron deficiency.

1981 ◽  
Vol 27 (2) ◽  
pp. 276-279 ◽  
Author(s):  
F Peter ◽  
S Wang
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Deficient ◽  
Iron Binding Capacity

Abstract Ferritin values for 250 selected sera were compared with values for iron, total iron-binding capacity (TIBC), and transferrin saturation, to assess the potential of the ferritin assay for the detection of latent iron deficiency. The specimens were grouped (50 in each group) according to their values for iron and TIBC. In Group 1 (low iron, high TIBC) the saturation and ferritin values both indicated iron deficiency in all but one. In the 100 specimens of Groups 2 (normal iron, high TIBC) and 4 (normal iron, high normal TIBC), the saturation values revealed 16 iron-deficient cases, the ferritin test 55. For Groups 3 (low iron, normal TIBC) and 5 (low iron, low TIBC), the ferritin test revealed fewer cases of iron deficiency than did the saturation values (37 cases vs 51 cases, in the 100 specimens). Evidently the ferritin test detects iron deficiency in many cases for whom the serum iron and TIBC tests are not positively indicative. The correlation of serum ferritin with iron, TIBC, and transferrin saturation in the five groups was good only in the case of specimens for which the TIBC was normal; if it was abnormal the correlation was very poor.

scholarly journals Association between Serum Ferritin and Iron Parameters with Preeclampsia and its Association with Perinatal Outcome

2019 ◽  
Vol 7 (1-2) ◽  
pp. 64-69
Author(s):  
Lipika Ghosh ◽  
Rowshan Afrooz ◽  
Saleha Begum Chowdhury ◽  
Osman Gani ◽  
Rokhshana Khatun
Keyword(s):  
Pregnant Women ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Outcome Variable ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Parameters ◽  
Iron Binding Capacity

Background & objective: To see the relationship between preeclampsia and iron parameters (serum iron, serum ferritin and total iron binding capacity). Methods: The present case-control study was carried out in the Department of Obstetrics & Gynaecology, Dhaka Medical College Hospital (DMCH), Dhaka in collaboration with the Department of Biochemistry, BSMMU, Dhaka over a period of 1 year from July 2012 to June 2013 Pregnant women with preeclampsia admitted in the above-mentioned hospital were considered as case, while the pregnant women without preeclampsia were included as control. A total of 60 women-31 cases and 29 controls were purposively included in the study. The exposure variables were serum ferritin, serum iron and total iron binding capacity (TIBC), while the outcome variable was preeclampsia. The serum iron level > 100 μg/L was considered as hyperferritenemia. Result: Nearly two-thirds of the women were in their 2nd decades of life belonged to lower socioeconomic class. The body mass index was also fairly comparable between the groups with most women having normal BMI. No significant difference was observed between the groups with respect to obstetric variables as well. Level of haemoglobin and hematocrit were also identically distributed between groups. The result showed that a significantly higher proportion (35.5%) preeclamptic women had elevated serum ferritin (> 100 μg/L) as opposed to 10.3% of the control group (p = 0.021). The risk of developing raised serum ferritin in women with preeclampsia was estimated to be 4-fold (95% CI =1.2 – 19.4) higher than that in the normal pregnant women. Analyses also revealed that women with severe preeclampsia had a higher mean serum ferritin (207.3 ± 44.1 ng/ml) than the women with mild preeclampsia (41.7 ± 2.7) and an even higher level compared with the normal pregnant women (21.7 ± 1.4 μg/ml) (p = 0.001). Similar result was observed in serum iron with greater the severity, higher is the level of serum iron (p = 0.067). Conversely, the serum total iron binding capacity (TIBC) was decreased with severity of preeclampsia (p = 0.058). Conclusion: The study concluded that women with preeclamsia might be associated with higher serum ferritin, higher serum iron and lower serum TIBC although it is not known whether the rise in serum ferritin and serum iron precedes or contributes to the clinical manifestations of preeclampsia. Ibrahim Card Med J 2017; 7 (1&2): 64-69

CIRCADIAN RHYTHM OF PLASMA IRON, TOTAL IRON BINDING CAPACITY AND SERUM FERRITIN IN ARTERIOSCLEROTIC AGED PATIENTS

1981 ◽  
Vol 10 (2) ◽  
pp. 115-118 ◽  
Author(s):  
GIORGIO CASALE ◽  
ANNA MIGLIAVACCA ◽  
CARLO BONORA ◽  
IVAN E. ZURITA ◽  
PIETRO de NICOLA
Keyword(s):  
Circadian Rhythm ◽  
Serum Ferritin ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Aged Patients ◽  
Plasma Iron ◽  
Iron Binding Capacity

Changes in Serum Ferritin and other ‘Acute Phase’ Proteins following Major Surgery

1984 ◽  
Vol 21 (4) ◽  
pp. 290-294 ◽  
Author(s):  
Caroline Rubin ◽  
P J Wood ◽  
T Archer ◽  
D J F Rowe
Keyword(s):  
Serum Ferritin ◽  
Binding Capacity ◽  
Gastrointestinal Surgery ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Healthy Women ◽  
Iron Binding Capacity

We have measured ferritin concentrations in healthy women, and ferritin, C-reactive protein, iron and total iron-binding capacity in patients undergoing hysterectomy or major gastrointestinal surgery. Pre-operative serum ferritin concentrations in patients awaiting hysterectomy were significantly lower than those for patients awaiting gastrointestinal surgery and also lower than those for healthy women of similar age. Healthy women aged between 51 and 60 years had significantly higher ferritin levels than women aged 35–50 years. All patients studied showed large increases in serum ferritin and C-reactive protein concentrations after surgery and approximately similar decreases in iron and in total iron-binding capacity.

Day-to-day variation in serum ferritin concentration in healthy subjects.

1981 ◽  
Vol 27 (1) ◽  
pp. 78-82 ◽  
Author(s):  
V A Pilon ◽  
P J Howanitz ◽  
J H Howanitz ◽  
N Domres
Keyword(s):  
Serum Ferritin ◽  
Healthy Subjects ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Ferritin Concentration ◽  
Iron Saturation ◽  
Iron Binding Capacity

Abstract We report our observations on day-to-day variation in serum ferritin, serum iron, total iron-binding capacity, and percent saturation of binding proteins with iron in 13 ostensibly healthy subjects during five weeks. The average intrasubject coefficients of variation were 14.5, 28.5, 4.8, and 28.0%, respectively. Precision studies on control samples showed greater within-assay and between-assay analytical variation for serum ferritin than for serum iron or total iron-binding capacity. Evidently, serum ferritin varies less in a given individual from day to day than do serum iron and percent iron saturation. Thus, a single measurement of serum ferritin may be a more reliable index of iron stores than an isolated determination of either serum iron or percent iron saturation.

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