Determination of Serum Iron, Total Iron-Binding Capacity and Serum Ferritin in Healthy Saudi Adults

2001 ◽  
Vol 21 (1-2) ◽  
pp. 100-103 ◽  
Author(s):  
Ahlan M. Al-Buhairan ◽  
Olayide A. Oluboyede
Keyword(s):  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Binding Capacity

Serum iron and total iron-binding capacity compared with serum ferritin in assessment of iron deficiency.

1981 ◽  
Vol 27 (2) ◽  
pp. 276-279 ◽  
Author(s):  
F Peter ◽  
S Wang
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Transferrin Saturation ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Deficient ◽  
Iron Binding Capacity

Abstract Ferritin values for 250 selected sera were compared with values for iron, total iron-binding capacity (TIBC), and transferrin saturation, to assess the potential of the ferritin assay for the detection of latent iron deficiency. The specimens were grouped (50 in each group) according to their values for iron and TIBC. In Group 1 (low iron, high TIBC) the saturation and ferritin values both indicated iron deficiency in all but one. In the 100 specimens of Groups 2 (normal iron, high TIBC) and 4 (normal iron, high normal TIBC), the saturation values revealed 16 iron-deficient cases, the ferritin test 55. For Groups 3 (low iron, normal TIBC) and 5 (low iron, low TIBC), the ferritin test revealed fewer cases of iron deficiency than did the saturation values (37 cases vs 51 cases, in the 100 specimens). Evidently the ferritin test detects iron deficiency in many cases for whom the serum iron and TIBC tests are not positively indicative. The correlation of serum ferritin with iron, TIBC, and transferrin saturation in the five groups was good only in the case of specimens for which the TIBC was normal; if it was abnormal the correlation was very poor.

scholarly journals Association between Serum Ferritin and Iron Parameters with Preeclampsia and its Association with Perinatal Outcome

2019 ◽  
Vol 7 (1-2) ◽  
pp. 64-69
Author(s):  
Lipika Ghosh ◽  
Rowshan Afrooz ◽  
Saleha Begum Chowdhury ◽  
Osman Gani ◽  
Rokhshana Khatun
Keyword(s):  
Pregnant Women ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Outcome Variable ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Iron Parameters ◽  
Iron Binding Capacity

Background & objective: To see the relationship between preeclampsia and iron parameters (serum iron, serum ferritin and total iron binding capacity). Methods: The present case-control study was carried out in the Department of Obstetrics & Gynaecology, Dhaka Medical College Hospital (DMCH), Dhaka in collaboration with the Department of Biochemistry, BSMMU, Dhaka over a period of 1 year from July 2012 to June 2013 Pregnant women with preeclampsia admitted in the above-mentioned hospital were considered as case, while the pregnant women without preeclampsia were included as control. A total of 60 women-31 cases and 29 controls were purposively included in the study. The exposure variables were serum ferritin, serum iron and total iron binding capacity (TIBC), while the outcome variable was preeclampsia. The serum iron level > 100 μg/L was considered as hyperferritenemia. Result: Nearly two-thirds of the women were in their 2nd decades of life belonged to lower socioeconomic class. The body mass index was also fairly comparable between the groups with most women having normal BMI. No significant difference was observed between the groups with respect to obstetric variables as well. Level of haemoglobin and hematocrit were also identically distributed between groups. The result showed that a significantly higher proportion (35.5%) preeclamptic women had elevated serum ferritin (> 100 μg/L) as opposed to 10.3% of the control group (p = 0.021). The risk of developing raised serum ferritin in women with preeclampsia was estimated to be 4-fold (95% CI =1.2 – 19.4) higher than that in the normal pregnant women. Analyses also revealed that women with severe preeclampsia had a higher mean serum ferritin (207.3 ± 44.1 ng/ml) than the women with mild preeclampsia (41.7 ± 2.7) and an even higher level compared with the normal pregnant women (21.7 ± 1.4 μg/ml) (p = 0.001). Similar result was observed in serum iron with greater the severity, higher is the level of serum iron (p = 0.067). Conversely, the serum total iron binding capacity (TIBC) was decreased with severity of preeclampsia (p = 0.058). Conclusion: The study concluded that women with preeclamsia might be associated with higher serum ferritin, higher serum iron and lower serum TIBC although it is not known whether the rise in serum ferritin and serum iron precedes or contributes to the clinical manifestations of preeclampsia. Ibrahim Card Med J 2017; 7 (1&2): 64-69

Evaluation of a radiometric method for determination of total and unsaturated iron-binding capacities and serum iron.

1978 ◽  
Vol 24 (2) ◽  
pp. 374-376 ◽  
Author(s):  
A N Fudge ◽  
C G Fraser
Keyword(s):  
Serum Iron ◽  
Binding Capacity ◽  
Flow Analysis ◽  
Correlation Coefficients ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Consensus Values ◽  
Iron Binding Capacity

Abstract We describe an evaluation of the "RES-OMAT FE-59" radiometric kit (Mallinckrodt Australia Pty. Ltd.) for determination of total iron-binding capacity and unsaturated iron-binding capacity; serum iron may be calculated from total iron-binding capacity and unsaturated iron-binding capacity. Values obtained on patients' sera were compared with those obtained by continuous-flow analysis; correlation coefficients were 0.92, 0.93, and 0.88 for total iron-binding capacity, unsaturated iron-binding capacity, and iron, respectively. Precision between-run and within-run was almost identical and compares very favorably with that reported by Dixon [Ann. Clin. Biochem. 10, 127 (1973)] and that achieved in inter-laboratory surveys. Analytical recovery averaged only 83.5%, but results of analyses of sera with assigned or consensus values showed good accuracy. Satisfactory performance cannot be achieved with lyophilzed bovine quality-control materials. The kit has significant technical advantages over colorimetric methods and good short- and long-term analytical performance.

Simplified Determination of Serum Iron and Total Iron-Binding Capacity

1970 ◽  
Vol 16 (2) ◽  
pp. 92-96 ◽  
Author(s):  
John A O’Malley ◽  
Anne Hassan ◽  
Judith Shiley ◽  
Henry Traynor
Keyword(s):  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Ferrous Ion ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Color Reagent ◽  
The Difference ◽  
Iron Binding Capacity

Abstract 2,4,6-Tripyridyl-s-triazine (TPTZ) is a color reagent for ferrous ion in the pH range 2 to 10, when ascorbic acid is used as the reducing agent. In this range TPTZ and ferrous ion combine in the ratio of two to one. Tris buffer is commonly used to maintain an alkaline pH, but it reacts with other reducing agents, rendering them ineffective. These observations suggested a method for the joint determination of serum iron and total iron-binding capacity (TIBC), all done in a single tube and with one color reagent. The method is compared with those of Peters et al. The standard deviation of the difference between the serum iron methods is less than 6 µg/100 ml, between the TIBC methods, less than 19 µg/100 ml.

Day-to-day variation in serum ferritin concentration in healthy subjects.

1981 ◽  
Vol 27 (1) ◽  
pp. 78-82 ◽  
Author(s):  
V A Pilon ◽  
P J Howanitz ◽  
J H Howanitz ◽  
N Domres
Keyword(s):  
Serum Ferritin ◽  
Healthy Subjects ◽  
Serum Iron ◽  
Binding Capacity ◽  
Total Iron ◽  
Iron Binding ◽  
Total Iron Binding Capacity ◽  
Ferritin Concentration ◽  
Iron Saturation ◽  
Iron Binding Capacity

Abstract We report our observations on day-to-day variation in serum ferritin, serum iron, total iron-binding capacity, and percent saturation of binding proteins with iron in 13 ostensibly healthy subjects during five weeks. The average intrasubject coefficients of variation were 14.5, 28.5, 4.8, and 28.0%, respectively. Precision studies on control samples showed greater within-assay and between-assay analytical variation for serum ferritin than for serum iron or total iron-binding capacity. Evidently, serum ferritin varies less in a given individual from day to day than do serum iron and percent iron saturation. Thus, a single measurement of serum ferritin may be a more reliable index of iron stores than an isolated determination of either serum iron or percent iron saturation.

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