Statistical comparison of blood glucose as determined by several test-strip procedures and by a hexokinase procedure.

1983 ◽  
Vol 29 (1) ◽  
pp. 132-135 ◽  
Author(s):  
T C Stewart ◽  
R M Kleyle
Keyword(s):  
Blood Glucose ◽  
Whole Blood ◽  
Test Strip ◽  
Statistical Tool ◽  
Statistical Comparison ◽  
Ordinal Comparison ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract We report a new statistical tool for comparing several dry-reagent strip procedures for whole blood glucose, which produce data in both digital and ordinal form, with results by the well-studied hexokinase-glucose-6-phosphate dehydrogenase procedure coupled to NAD+-NADH. Our use of "ordinal comparison unit" allows for a more equitable comparison of such data. These strip procedures produce biases of -2.21 to 1.74 ordinal comparison units over the range of glucose values corresponding to hypoglycemia and hyperglycemia, as compared with results by the hexokinase procedure, but they are essentially equivalent when compared with each other.

Development and evaluation of a glucose analyzer for a glucose controlled insulin infusion system ((Biostator).

1978 ◽  
Vol 24 (8) ◽  
pp. 1366-1372 ◽  
Author(s):  
E J Fogt ◽  
L M Dodd ◽  
E M Jenning ◽  
A H Clemens
Keyword(s):  
Blood Glucose ◽  
Whole Blood ◽  
Insulin Infusion ◽  
Full Range ◽  
Dynamic Control ◽  
On Line ◽  
The Moment ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Blood Glucose Concentrations ◽  
Infusion System

Abstract The Glucose-Controlled Insulin Infusion System (Biostator) is a modular, computerized, feedback control system for dynamic control of blood glucose concentrations in diabetics. This on-line glucose analyzer for use with whole blood utilizes a novel enzyme (glucose oxidase)-membrane configuration and an electrochemical cell to measure the H202 generated. The analyzer exhibits both short- and long-range stability, and instrument response and analyte concentration are linearly related over the full range of clinical interest. The response is fast, accurate, and precise, and permits determination of blood glucose within 2 min from the moment the blood leaves the patient. Correlation studies were completed to show the agreement between the Biostator Glucose Analyzer and the FDA's recommended hexokinase/glucose-6-phosphate dehydrogenase procedure on whole blood (e.g., average per cent recovered for 11 concentrations between 250 and 900 mg/liter was: hexokinase, 95.6%, Biostator Analyzer, 95.9%; bias and SDd, respectively, at low, normal, and high glucose values were: 12 and 41 mg/liter at the 500 mg/liter level; 4 and 52 mg/liter at the 1000 mg/liter level, and 4 and 128 mg/liter at the 4000 mg/liter level). No appreciable interference is observed with above-normal concentrations of bilirubin, uric acid, creatinine, sodium salicylate, or dextran. Platelet adhesion, which tends to decrease the useful life of the membrane, has been significantly decreased.

scholarly journals Fabrication methods for a gel-based separation-free device for whole blood glucose detection

MethodsX ◽  
2021 ◽  
Vol 8 ◽  
pp. 101236
Author(s):  
Han Zhang ◽  
Yongjian Yang ◽  
Jing Dai ◽  
Arum Han
Keyword(s):  
Blood Glucose ◽  
Whole Blood ◽  
Glucose Detection

Glucose and Adenosine Triphosphate Level in Normal Subjects

1974 ◽  
Vol 125 (588) ◽  
pp. 459-460 ◽  
Author(s):  
J. Damas Mora ◽  
D. Vlissides ◽  
F. A. Jenner
Keyword(s):  
Blood Glucose ◽  
Correlation Coefficient ◽  
Adenosine Triphosphate ◽  
Whole Blood ◽  
Normal Subjects ◽  
Red Cell ◽  
Linus Pauling

In Orthomolecular Psychiatry; Treatment of Schizophrenia, edited by David Hawkins and Linus Pauling (1973), Beebe and Wendel (pp. 278–302) report a high correlation coefficient of r = 0.99 (which we calculate gives N = 42, p very much lower than 0.001) between whole blood glucose and adenosine triphosphate (ATP). This relationship they claim is no longer maintained in schizophrenics with anxiety, r = 0.16 (N = 62, p > 0.1). Erban and Hanzlicek (1966), Hansen (1972) and Hansen and Dimitrakoudi (1974) have suggested a possible significance of whole blood ATP in psychoses, and Naylor, Dick, Dick, Le Poidevin and Whyte (1973) have implicated red cell Na/K ATPases. The mechanisms involved in controlling blood ATP seemed therefore worthy of study especially if they are so dependent on glucose.

scholarly journals Accuracy Evaluation of a New System for Self-Monitoring of Blood Glucose With Three Test Strip Lots Based on ISO 15197:2013

2017 ◽  
Vol 12 (2) ◽  
pp. 539-540 ◽  
Author(s):  
Annette Baumstark ◽  
Nina Jendrike ◽  
Stefan Pleus ◽  
Christina Liebing ◽  
Cornelia Haug ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Test Strip ◽  
Accuracy Evaluation ◽  
Self Monitoring ◽  
New System

scholarly journals Accuracy of Capillary and Arterial Whole Blood Glucose Measurements Using a Glucose Meter in Patients under General Anesthesia in the Operating Room

2017 ◽  
Vol 127 (3) ◽  
pp. 466-474 ◽  
Author(s):  
Brad S. Karon ◽  
Leslie J. Donato ◽  
Chelsie M. Larsen ◽  
Lindsay K. Siebenaler ◽  
Amy E. Wells ◽  
...  
Keyword(s):  
Blood Glucose ◽  
General Anesthesia ◽  
Operating Room ◽  
Whole Blood ◽  
Insulin Infusion ◽  
Subcutaneous Insulin ◽  
Intravenous Insulin ◽  
Diabetes Status ◽  
Glucose Meter ◽  
Arterial Glucose

Abstract Background The aim of this study was to evaluate the use of a glucose meter with surgical patients under general anesthesia in the operating room. Methods Glucose measurements were performed intraoperatively on 368 paired capillary and arterial whole blood samples using a Nova StatStrip (Nova Biomedical, USA) glucose meter and compared with 368 reference arterial whole blood glucose measurements by blood gas analyzer in 196 patients. Primary outcomes were median bias (meter minus reference), percentage of glucose meter samples meeting accuracy criteria for subcutaneous insulin dosing as defined by Parkes error grid analysis for type 1 diabetes mellitus, and accuracy criteria for intravenous insulin infusion as defined by Clinical and Laboratory Standards Institute guidelines. Time under anesthesia, patient position, diabetes status, and other variables were studied to determine whether any affected glucose meter bias. Results Median bias (interquartile range) was −4 mg/dl (−9 to 0 mg/dl), which did not differ from median arterial meter bias of −5 mg/dl (−9 to −1 mg/dl; P = 0.32). All of the capillary and arterial glucose meter values met acceptability criteria for subcutaneous insulin dosing, whereas only 89% (327 of 368) of capillary and 93% (344 of 368) arterial glucose meter values met accuracy criteria for intravenous insulin infusion. Time, patient position, and diabetes status were not associated with meter bias. Conclusions Capillary and arterial blood glucose measured using the glucose meter are acceptable for intraoperative subcutaneous insulin dosing. Whole blood glucose on the meter did not meet accuracy guidelines established specifically for more intensive (e.g., intravenous insulin) glycemic control in the acute care environment.

Determination of Glucose in Serum and Whole Blood: Statistical Relationships between Values Obtained by Different Methods

1972 ◽  
Vol 18 (9) ◽  
pp. 976-979 ◽  
Author(s):  
David G Geeting ◽  
Charles A Suther ◽  
Philip Sylbert
Keyword(s):  
Blood Glucose ◽  
Blood Sample ◽  
Whole Blood ◽  
Serum Glucose ◽  
Statistical Relationships ◽  
Single Blood Sample

Abstract Several methods are available for determination of glucose in whole blood and serum. When comparing the results of these methods on a single blood sample, one may find significantly different values. Here, equations are provided for converting values for whole blood glucose to values for serum glucose, obtained by different methods.

scholarly journals The Influence of Blood Glucose Meter Resistance Variation on the Performance of a Biosensor with a Gold-Coated Circuit Board

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Kun-Yong Kim ◽  
Ho Chang ◽  
Win-Der Lee ◽  
Yi-Fan Cai ◽  
You-Jia Chen
Keyword(s):  
Blood Glucose ◽  
Glucose Oxidase ◽  
Economies Of Scale ◽  
Electrochemical Reaction ◽  
Test Strip ◽  
Circuit Board ◽  
Potential Range ◽  
Test Strips ◽  
Glucose Meter ◽  
Blood Glucose Meter

In this study, a novel gold-coated test strip for blood glucose measurement has been designed. Such gold-coated test strip is feasible for mass production to achieve economies of scale. Cyclic voltammetry was applied to test strips to undergo electrochemical reaction under a potential range of ±0.4 V. Glucose oxidase (GOD) was added into K3[Fe(CN)6]. When glucose oxidase undergoes electrochemical reaction, the medium, K3[Fe(CN)6], will act as an electron acceptor, causing the electrodes on the test strip to generate a pair of clear anodic and reductive peaks. The maximum of the anodic and reductive peaks can be used as reference to adjust the resistance of the blood glucose meter. The experimental results show that by adjusting the resistance of the blood glucose meter, the accuracy of blood glucose meter reading can be tuned and blood glucose reading can be stabilized. Therefore, when the resistance of the blood glucose meter is at 2.4 KΩ, the standard deviation (STD) and coefficient of variation (CV) of the test strip are lower than those of the test strips measured at resistances of 2.2 KΩ and 2.6 KΩ. It has been proved in this study that adjusting the resistance of the blood glucose meter can optimize the chemical reaction on gold-coated test strips as well as its reading. This method can also be applied to tune the accuracy of readings for test strips coated with other materials.

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