Chemical Findings in Patients with Acute Nonfatal Barbiturate Intoxication

1957 ◽  
Vol 3 (3) ◽  
pp. 125-134 ◽  
Author(s):  
Irving Sunshine ◽  
Earl Hackett

Abstract 1. Clinical and chemical data on acutely intoxicated patients show a direct quantitative relationship of the patient's blood barbiturate levels to his clinical condition. 2. The "half-life" of phenobarbital, amobarbital, and pentobarbital was determined to aid in prognosis of an intoxicated patient with a given blood barbiturate level. 3. Urinary clearance studies showed that the clearance was directly proportional to the urine flow. 4. A patient's urine barbiturate level has no relation to his clinical condition.

1964 ◽  
Vol 65 (6) ◽  
pp. 1103
Author(s):  
William Paul Glezen ◽  
George A. Lamb ◽  
Tom D.Y. Chin ◽  
Herbert A. Wenner

1976 ◽  
Vol 108 (4) ◽  
pp. 353-362 ◽  
Author(s):  
Robert N. Coulson ◽  
Adil M. Mayyasi ◽  
J. L. Foltz ◽  
F. P. Hain ◽  
W. C. Martin

AbstractThe process of resource utilization by Dendroctonus frontalis Zimmerman attacking loblolly pine, Pinus taeda L., was investigated. The quantitative relationship of attacking parent adult D. frontalis as a function of the normalized infested bole height is described by the model y = Ax(1−x)eBx. Greatest attack density occurs at the mid-bole of the tree and tapers toward the top and bottom. Gallery length (and hence eggs)/100 cm2 was independent of attack density. The relationship between gallery length (or eggs) per parent adult and parent adult density is described by the exponential decay curve y = AeBx, indicating that gallery length and egg population density are controlled by a density dependent compensatory feedback process operating instantaneously. Further support for the mechanism was obtained by analyzing the gallery length per parent adult at different locations on the infested bole. The relationship is described by the model y = [AeBx]/[x(1−x)] and indicates that gallery construction and egg population per attacking beetle increase in the upper and basal portion of the bole. The result is a uniform amount of food and space per individual of the developing population.


2020 ◽  
Vol 19 (3) ◽  
pp. 482-493
Author(s):  
L. Yang ◽  
B. Yang ◽  
G. W. Yang ◽  
S. N. Xiao ◽  
T. Zhu ◽  
...  

2010 ◽  
Vol 7 (1) ◽  
pp. 78-82
Author(s):  
Harno Dwi Pranowo ◽  
Iqmal Tahir ◽  
Ajidarma Widiatmoko

Electronic structure and inhibition activity relationship study of curcumin analogs has been established for 29 curcumin analogs on Ethoxyresorufin O-Dealkylation (EROD) reaction using atomic net charge descriptor based on AM1 semiempirical calculations. The QSAR (Quantitative Structure and Activities Relationships) equation model was determined by statistical parameter from multiple regression analysis and leave-one-out cross validation method. The best QSAR equation was described:   Keywords: curcumin, QSAR, descriptor, atomic net charge, semiempirical methods.


2001 ◽  
Vol 6 (1) ◽  
pp. 39-43 ◽  
Author(s):  
DAVID M. POLLOCK

Renal clearance studies were conducted to determine the role of ETB receptors in the renal response to big endothelin-1 (big ET-1). Two series of experiments were conducted on Inactin-anesthetized rats to contrast acute pharmacological blockade of ETB receptors vs. genetic ETB receptor deficiency. In the first series, Sprague-Dawley rats were given either ETB-selective antagonist, A-192621, or vehicle (0.9% NaCl) prior to infusion of big ET-1 (10 pmol·kg−1·min−1) for 60 min. A-192621 significantly increased baseline mean arterial pressure (MAP; 102 ± 4 vs. 141 ± 6 mmHg, P < 0.05) and urine flow rate (0.5 ± 0.1 vs. 1.3 ± 0.2 μl/min, P < 0.05) without any effect on glomerular filtration rate (GFR) or effective renal plasma flow (ERPF). Big ET-1 significantly increased MAP in both groups but to a higher level in rats given antagonist (120 ± 6 vs. 169 ± 6 mmHg, P < 0.05). Big ET-1 increased urine flow in control rats but decreased in rats given antagonist. GFR and ERPF were decreased in rats given big ET-1, an effect that was exaggerated by ETB blockade. Another series of experiments examined the response to big ET-1 in rats lacking functional renal ETB receptors, known as spotting lethal ( sl) rats. Surprisingly, rats heterozygous ( sl/+) for ETB receptor deficiency had a significantly higher baseline MAP compared with homozygous ( sl/ sl) rats (134 ± 6 vs. 112 ± 7 mmHg, P < 0.05), although other variables were similar. Big ET-1 produced no significant change in MAP in either group. Urine flow, GFR, and ERPF were significantly decreased in both groups, although these changes were much larger in sl/ sl rats. These experiments indicate that the ETB receptor plays an important role in limiting the renal hemodynamic response to big ET-1. Furthermore, the diuretic actions of big ET-1 require a functional ETB receptor.


2012 ◽  
Vol 198-199 ◽  
pp. 367-373
Author(s):  
Guo Liang Yang ◽  
Jin Hui Zhang ◽  
Hui Sun

An emotional interaction system is designed by using the theories about affective computing in this paper, which includes the emotional information capturing, machine emotional model and emotional expression. This paper focuses on the problem of building machine emotional model, not only gives the basic definitions of personality space, mood space, and emotion space, but also establishes the quantitative relationship of personality mood and emotion. At last, this paper builds a machine affective model which can reflect the transformation law of the mood, emotion and personality. Related simulation results show that the model can effectively simulates the change law of human emotion. Finally, this paper designs the software interface of the emotional interaction system.


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