High-performance liquid chromatography/mass spectrometry: state of the art for the drug analysis laboratory.
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Abstract The combination of HPLC and mass spectrometry has great promise for the toxicology laboratory. In the past five years, significant progress has been made toward producing a reliable interface for these techniques. Thermospray, liquid ion evaporation, ion-spray, and the particle beam separator are all viable "second generation" approaches with significant advantages and disadvantages. I review the operation of these interfaces with an orientation to their use in the drug analysis laboratory. Thermospray, ion-spray, and liquid ion evaporation primarily supply information about molecular mass. The benefits and limitations of using tandem mass spectrometry to obtain additional structural information will also be discussed.
1994 ◽
Vol 23
(8)
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pp. 483-491
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1991 ◽
Vol 549
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pp. 237-245
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1996 ◽
Vol 730
(1-2)
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pp. 231-240
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1993 ◽
Vol 647
(2)
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pp. 203-210
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1990 ◽
Vol 1
(1)
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pp. 92-98
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1998 ◽
Vol 799
(1-2)
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pp. 111-115
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1994 ◽
Vol 688
(1-2)
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pp. 55-65
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1996 ◽
Vol 7
(5)
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pp. 228-232
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1997 ◽
Vol 690
(1-2)
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pp. 153-159
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1994 ◽
Vol 688
(1-2)
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pp. 67-73
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