Complexation of Iron with the Orally Active Decorporation Drug L1 (3-Hydroxy-1,2-Dimethyl-4-Pyridinone)

1992 ◽  
Vol 38 (4) ◽  
pp. 562-565 ◽  
Author(s):  
M A Kline ◽  
C Orvig
Keyword(s):  
Blood Plasma ◽  
Potentiometric Titration ◽  
Stability Constants ◽  
Computer Model ◽  
Chelating Agent ◽  
Glass Electrode ◽  
Simple Computer ◽  
Active Iron ◽  
The Stability ◽  
Orally Active

Abstract The stability constants for the Fe(III) complexes of the orally active iron decorporation drug L1 (3-hydroxy-1,2-dimethyl-4-pyridinone) have been determined by potentiometric titration [glass electrode, 25.0 degrees C, mu = 0.15 mol/L (isotonic) NaCl]. A simple computer model of blood plasma (citrate 100 mumol/L, transferrin 37 mumol/L) has been used to compare the Fe(III) binding efficacies in blood of L1 and the clinically used intravenously administered chelating agent deferoxamine.

SODIUM CHELATES OF ETHYLENEDIAMINETETRAACETIC ACID

1963 ◽  
Vol 41 (1) ◽  
pp. 18-20 ◽  
Author(s):  
Vladimir Palaty
Keyword(s):  
Stability Constant ◽  
Stability Constants ◽  
Ethylenediaminetetraacetic Acid ◽  
Glass Electrode ◽  
Neutral Solution ◽  
Experimental Conditions ◽  
The Stability ◽  
Sensitive Method

The stability constant of the sodium chelate of EDTA was determined by means of a sodium-sensitive glass electrode. It appears that a hydrogen chelate of the formula NaHY2− is formed in the neutral solution of EDTA, but is very unstable. The stability constants, pKNaY = −2.61 and pKNaHY = 0.03, are comparable to the value obtained by Schwarzenbach and Ackermann under different experimental conditions by a less sensitive method.

Transferrin binding of Al3+ and Fe3+.

1987 ◽  
Vol 33 (3) ◽  
pp. 405-407 ◽  
Author(s):  
R B Martin ◽  
J Savory ◽  
S Brown ◽  
R L Bertholf ◽  
M R Wills
Keyword(s):  
Stability Constant ◽  
Blood Plasma ◽  
Stability Constants ◽  
Metal Ion ◽  
Equilibrium Dialysis ◽  
Ion Binding ◽  
Metal Ion Binding ◽  
Quantitative Studies ◽  
Intensity Changes ◽  
The Stability

Abstract An understanding of Al3+-induced diseases requires identification of the blood carrier of Al3+ to the tissues where Al3+ exerts a toxic action. Quantitative studies demonstrate that the protein transferrin (iron-free) is the strongest Al3+ binder in blood plasma. Under plasma conditions of pH 7.4 and [HCO3-]27 mmol/L, the successive stability constant values for Al3+ binding to transferrin are log K1 = 12.9 and log K2 = 12.3. When the concentration of total Al3+ in plasma is 1 mumol/L, the free Al3+ concentration permitted by transferrin is 10(-14.6) mol/L, less than that allowed by insoluble Al(OH)3, by Al(OH)2H2PO4, or by complexing with citrate. Thus transferrin is the ultimate carrier of Al3+ in the blood. We also used intensity changes produced by metal ion binding to determine the stability constants for Fe3+ binding to transferrin: log K1 = 22.7 and log K2 = 22.1. These constants agree closely with a revision of the reported values obtained by equilibrium dialysis. By comparison with Fe3+ binding, the Al3+ stability constants are weaker than expected; this suggests that the significantly smaller Al3+ ions cannot coordinate to all the transferrin donor atoms available to Fe3+.

scholarly journals Effect of Grafted Hydroquinone on the Acid-Base Properties of Poly(acrylic acid) in the Presence of Copper (II)

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Nabila Bensacia ◽  
Saâd Moulay ◽  
François Garin ◽  
Ioana Fechete ◽  
Anne Boos
Keyword(s):  
Acrylic Acid ◽  
Coordination Number ◽  
Potentiometric Titration ◽  
Stability Constants ◽  
Acid Base ◽  
Polymer Complexes ◽  
Ionic Environment ◽  
The Stability ◽  
Hasselbalch Equation ◽  
Poly Acrylic Acid

Potentiometric titration of poly(acrylic acid) and hydroquinone-functionalized poly(acrylic acid) was conducted in the presence of copper (II). The effects of hydroquinone functionalizing and copper (II) complexing on the potentiometric titration of poly(acrylic acid) were studied in an ionic environment and in its absence. Henderson-Hasselbalch equation was applied to assess its validity for this titration. Coordination number and the stability constants of the copper- (II-)complexed polymers were determined, and results showed the formation of mostly monodentate and bidentate copper- (II-)polymer complexes.

scholarly journals Ternary Complexes in Solution, XX

1974 ◽  
Vol 29 (9-10) ◽  
pp. 654-657 ◽  
Author(s):  
Beda E. Fischer ◽  
Helmut Sigel
Keyword(s):  
Potentiometric Titration ◽  
Stability Constants ◽  
Ternary Complexes ◽  
Enhancing Effect ◽  
Titration Curves ◽  
The Stability ◽  
Comparison Of The Results

The stability constants of the ternary Cu2+ complexes containing 1,2-diaminobenzene and oxalate or salicylate have been calculated from potentiometric titration curves published by G. K. CHATURVEDI and J. P. TANDON (Z. Naturforsch. 23b, 303 [1968]; 25b, 26 [1970]). A comparison of the results with data of the literature reveals that the qualities of 1,2-diaminobenzene in ternary complexes correspond to those of ethylenediamine, while the qualities of both amines differ considerably from those of 2,2′-bipyridyl, which has a stability-enhancing effect.

Safety, Tolerability, and Pharmacokinetics of ICL670, a New Orally Active Iron-Chelating Agent in Patients with Transfusion-Dependent Iron Overload Due to β-Thalassemia

2003 ◽  
Vol 43 (6) ◽  
pp. 565-532 ◽  
Author(s):  
Renzo Galanello ◽  
Antonio Piga ◽  
Daniele Alberti ◽  
Marie-Claude Rouan ◽  
Hilde Bigler ◽  
...  
Keyword(s):  
Iron Overload ◽  
Chelating Agent ◽  
Active Iron ◽  
Orally Active

Safety, Tolerability, and Pharmacokinetics of ICL670, a New Orally Active Iron-Chelating Agent in Patients with Transfusion-Dependent Iron Overload Due to β-Thalassemia

2003 ◽  
Vol 43 (6) ◽  
pp. 565-572 ◽  
Author(s):  
Renzo Galanello ◽  
Antonio Piga ◽  
Daniele Alberti ◽  
Marie-Claude Rouan ◽  
Hilde Bigler ◽  
...  
Keyword(s):  
Iron Overload ◽  
Chelating Agent ◽  
Active Iron ◽  
Orally Active
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