The complement system in myocardial ischaemia/reperfusion injury

1994 ◽  
Vol 28 (4) ◽  
pp. 437-444 ◽  
Author(s):  
K. S Kilgore ◽  
G. S Friedrichs ◽  
J. W Homeister ◽  
B. R Lucchesi
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Complement System ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
The Complement System

scholarly journals Complement in ischaemia–reperfusion injury and transplantation

2021 ◽  
Author(s):  
Mark C. Howard ◽  
Christopher L. Nauser ◽  
Conrad A. Farrar ◽  
Steven H. Sacks
Keyword(s):  
T Cell ◽  
Reperfusion Injury ◽  
Complement System ◽  
Therapeutic Benefit ◽  
Rare Occurrence ◽  
Ischaemia Reperfusion Injury ◽  
Antibody Mediated Rejection ◽  
Ischaemia Reperfusion ◽  
The Complement System ◽  
Original Concept

AbstractUntil recently, the only known condition in which complement could mediate transplant injury was the rare occurrence of antibody-mediated rejection, in which the original concept of antibody immunity against the transplant was supported by complementary proteins present in the serum. This has changed within the last two decades because of evidence that the processes of ischaemia–reperfusion injury followed by T cell–mediated rejection are also critically dependent on components generated by the complement system. We now have a clearer understanding of the complement triggers and effectors that mediate injury, and a detailed map of their local sites of production and activation in the kidney. This is providing helpful guidelines as to how these harmful processes that restrict transplant outcomes can be targeted for therapeutic benefit. Here we review some of the recent advances highlighting relevant therapeutic targets.

Nitrite and myocardial ischaemia reperfusion injury. Where are we now?

2021 ◽  
Vol 223 ◽  
pp. 107819
Author(s):  
Kayleigh Griffiths ◽  
Jordan J. Lee ◽  
Michael P. Frenneaux ◽  
Martin Feelisch ◽  
Melanie Madhani
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Hypertrophic Preconditioning Attenuates Myocardial Ischaemia‐Reperfusion Injury by Modulating SIRT3‐SOD2‐mROS‐Dependent Autophagy

2021 ◽  
Author(s):  
Lei‐Lei Ma ◽  
Fei‐Juan Kong ◽  
Zheng Dong ◽  
Kai‐Yue Xin ◽  
Xing‐Xu Wang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Downregulation of microRNA-29 by antisense inhibitors and a PPAR-γ agonist protects against myocardial ischaemia–reperfusion injury

2010 ◽  
Vol 87 (3) ◽  
pp. 535-544 ◽  
Author(s):  
Yumei Ye ◽  
Zhaoyong Hu ◽  
Yu Lin ◽  
Congfang Zhang ◽  
Jose R. Perez-Polo
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Ischaemia Reperfusion Injury ◽  
Ppar Γ ◽  
Ischaemia Reperfusion

scholarly journals Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury

2005 ◽  
Vol 26 (21) ◽  
pp. 2334-2343 ◽  
Author(s):  
Yara Banz ◽  
Otto M. Hess ◽  
Simon C. Robson ◽  
Daniel Mettler ◽  
Pascal Meier ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Myocardial Ischaemia ◽  
Dextran Sulfate ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion
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