scholarly journals The potential role of the red blood cell in nitrite-dependent regulation of blood flow

2010 ◽  
Vol 89 (3) ◽  
pp. 507-515 ◽  
Author(s):  
Rakesh P. Patel ◽  
Neil Hogg ◽  
Daniel B. Kim-Shapiro
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Potential Role

scholarly journals Role of Red Blood Cell Released ATP in Disturbed Blood Flow‐Initiated Vascular Inflammation and Atherosclerosis

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Yunpei Zhang ◽  
Shaowei Huang ◽  
Kyle Brian LaPenna ◽  
Pingnian He
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Vascular Inflammation

Microvascular blood flow resistance: Role of red blood cell migration and dispersion

2015 ◽  
Vol 99 ◽  
pp. 57-66 ◽  
Author(s):  
Dinar Katanov ◽  
Gerhard Gompper ◽  
Dmitry A. Fedosov
Keyword(s):  
Blood Flow ◽  
Cell Migration ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Flow Resistance ◽  
Microvascular Blood Flow

In vivo microvascular structural and functional consequences of muscle length changes

1997 ◽  
Vol 272 (5) ◽  
pp. H2107-H2114 ◽  
Author(s):  
D. C. Poole ◽  
T. I. Musch ◽  
C. A. Kindig
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Oxygen Delivery ◽  
Sarcomere Length ◽  
Flow Dynamics ◽  
Capillary Diameter ◽  
Luminal Diameter ◽  
Length Changes

As muscles are stretched, blood flow and oxygen delivery are compromised, and consequently muscle function is impaired. We tested the hypothesis that the structural microvascular sequellae associated with muscle extension in vivo would impair capillary red blood cell hemodynamics. We developed an intravital spinotrapezius preparation that facilitated direct on-line measurement and alteration of sarcomere length simultaneously with determination of capillary geometry and red blood cell flow dynamics. The range of spinotrapezius sarcomere lengths achievable in vivo was 2.17 +/- 0.05 to 3.13 +/- 0.11 microns. Capillary tortuosity decreased systematically with increases of sarcomere length up to 2.6 microns, at which point most capillaries appeared to be highly oriented along the fiber longitudinal axis. Further increases in sarcomere length above this value reduced mean capillary diameter from 5.61 +/- 0.03 microns at 2.4-2.6 microns sarcomere length to 4.12 +/- 0.05 microns at 3.2-3.4 microns sarcomere length. Over the range of physiological sarcomere lengths, bulk blood flow (radioactive microspheres) decreased approximately 40% from 24.3 +/- 7.5 to 14.5 +/- 4.6 ml.100 g-1.min-1. The proportion of continuously perfused capillaries, i.e., those with continuous flow throughout the 60-s observation period, decreased from 95.9 +/- 0.6% at the shortest sarcomere lengths to 56.5 +/- 0.7% at the longest sarcomere lengths and was correlated significantly with the reduced capillary diameter (r = 0.711, P < 0.01; n = 18). We conclude that alterations in capillary geometry and luminal diameter consequent to increased muscle sarcomere length are associated with a reduction in mean capillary red blood cell velocity and a greater proportion of capillaries in which red blood cell flow is stopped or intermittent. Thus not only does muscle stretching reduce bulk blood (and oxygen) delivery, it also alters capillary red blood cell flow dynamics, which may further impair blood-tissue oxygen exchange.

Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation

2021 ◽  
Author(s):  
Tianhao Wang ◽  
Shouqin Lü ◽  
Yinjing Hao ◽  
Zinan Su ◽  
Mian Long ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformation ◽  
Hepatic Sinusoid

The role of policy in red blood cell storage and transfusion in children

2017 ◽  
Vol 82 (6) ◽  
pp. 894-896
Author(s):  
Jean L Raphael ◽  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Storage

scholarly journals Recent insights into nitrite signaling processes in blood

2017 ◽  
Vol 398 (3) ◽  
pp. 319-329 ◽  
Author(s):  
Christine C. Helms ◽  
Xiaohua Liu ◽  
Daniel B. Kim-Shapiro
Keyword(s):  
Nitric Oxide ◽  
Human Physiology ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Nitrite Reduction ◽  
No Production ◽  
The Past ◽  
Acidic Conditions ◽  
Hypoxic Vasodilation

Abstract Nitrite was once thought to be inert in human physiology. However, research over the past few decades has established a link between nitrite and the production of nitric oxide (NO) that is potentiated under hypoxic and acidic conditions. Under this new role nitrite acts as a storage pool for bioavailable NO. The NO so produced is likely to play important roles in decreasing platelet activation, contributing to hypoxic vasodilation and minimizing blood-cell adhesion to endothelial cells. Researchers have proposed multiple mechanisms for nitrite reduction in the blood. However, NO production in blood must somehow overcome rapid scavenging by hemoglobin in order to be effective. Here we review the role of red blood cell hemoglobin in the reduction of nitrite and present recent research into mechanisms that may allow nitric oxide and other reactive nitrogen signaling species to escape the red blood cell.

Blood viscosity during the neonatal period: The role of plasma and red blood cell type

1982 ◽  
Vol 100 (3) ◽  
pp. 449-453 ◽  
Author(s):  
Lise Riopel ◽  
Jean-Claude Fouron ◽  
Harry Bard
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Viscosity ◽  
Neonatal Period ◽  
Cell Type ◽  
Blood Cell Type

The effect of red blood cell flexibility on blood flow through tubes with diameters in the range 30 to 500 microns

Biorheology ◽  
1979 ◽  
Vol 16 (6) ◽  
pp. 473-483 ◽  
Author(s):  
V. Seshadri ◽  
C. McKay ◽  
M.Y. Jaffrin
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Flow Through
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