scholarly journals P244The possible modulating role of protease nexin 1 and plasmin/plasmingen associated to ldl receptor-related protein-1 in the pathogenesis of human ascending aortic aneurysm

2014 ◽  
Vol 103 (suppl 1) ◽  
pp. S43.5-S43
Author(s):  
L F Borges ◽  
L T Diniz ◽  
G D R Mello ◽  
R R Dias ◽  
P S Gutierrez ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Ldl Receptor ◽  
Related Protein ◽  
Ascending Aortic Aneurysm ◽  
Protease Nexin

Role of cAMP in LDL receptor-related protein 1 signalling

2007 ◽  
Vol 2007 (Fall) ◽  
Author(s):  
Niklas Schreiber ◽  
Joerg Heeren ◽  
Hartwig Schmale
Keyword(s):  
Ldl Receptor ◽  
Related Protein

Role of lipases and LDL receptor-related protein in human chylomicron remnant catabolism

1994 ◽  
Vol 109 (1-2) ◽  
pp. 82
Author(s):  
U. Beisiegel ◽  
W. Weber ◽  
A. Krapp ◽  
N. Meyer ◽  
G. Olivecrona ◽  
...  
Keyword(s):  
Ldl Receptor ◽  
Chylomicron Remnant ◽  
Related Protein

Role of LDL receptor-related protein (LRP) in coronary atherosclerosis

2003 ◽  
Vol 92 (2-3) ◽  
pp. 137-144 ◽  
Author(s):  
Susanne Schulz ◽  
Gerd Birkenmeier ◽  
Undraga Schagdarsurengin ◽  
Katrin Wenzel ◽  
Ursula Müller-Werdan ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
Ldl Receptor ◽  
Related Protein

Role of Heparan Sulfate Proteoglycans and the LDL Receptor-Related Protein in Remnant Lipoprotein Metabolism

1994 ◽  
Vol 737 (1 Biology of 2-) ◽  
pp. 39-52 ◽  
Author(s):  
ROBERT W. MAHLEY ◽  
ZHONG-SHENG JI ◽  
WALTER J. BRECHT ◽  
R. DENNIS MIRANDA ◽  
DONGPING HE
Keyword(s):  
Heparan Sulfate ◽  
Ldl Receptor ◽  
Lipoprotein Metabolism ◽  
Heparan Sulfate Proteoglycans ◽  
Related Protein ◽  
Remnant Lipoprotein

scholarly journals A Case Report of Giant Ascending Aortic Aneurysm: Role of Multimodality Imaging

Aorta ◽  
2021 ◽  
Author(s):  
Shabir H. Shah ◽  
Muhammad A. Shah ◽  
Abudar A. M. Alganadi ◽  
Halia Z. Alshehri ◽  
Mudasir S. Mir ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Multimodality Imaging ◽  
The Elderly ◽  
Rapid Expansion ◽  
Maximum Diameter ◽  
Ascending Aortic Aneurysm ◽  
Increased Risk ◽  
Risk Of Rupture ◽  
Common Etiology

AbstractGiant ascending aortic aneurysm (AscAA >10 cm) is an uncommon entity with a variable presentation. The size of the aneurysm, rapid expansion, and calcification are associated with an increased risk of rupture. Atherosclerosis is the most common etiology of aortic aneurysm in the elderly population. Multimodality imaging can be wisely used for diagnosis, risk stratification, and follow-up. We herein report a case of successfully repaired giant calcified AscAA with a maximum diameter of 10 cm. We also provide a brief discussion on the role of multimodality imaging.

scholarly journals Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature

2018 ◽  
Vol 19 (11) ◽  
pp. 1276-1288 ◽  
Author(s):  
Dianaly T. Au ◽  
Allison L. Arai ◽  
William E. Fondrie ◽  
Selen C. Muratoglu ◽  
Dudley K. Strickland
Keyword(s):  
Signaling Pathways ◽  
Protease Activity ◽  
Ldl Receptor ◽  
Related Protein

The role of the low-density lipoprotein receptor–related protein 1 (LRP-1) in regulating blood-brain barrier integrity

2016 ◽  
Vol 27 (6) ◽  
pp. 623-634 ◽  
Author(s):  
Yahui Zhao ◽  
Dandong Li ◽  
Junjie Zhao ◽  
Jinning Song ◽  
Yonglin Zhao
Keyword(s):  
Endothelial Cells ◽  
Low Density Lipoprotein ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Related Protein ◽  
Tight Junction Proteins ◽  
The Brain ◽  
Junction Proteins

AbstractThe blood-brain barrier (BBB) is a protective structure that helps maintaining the homeostasis in cerebral microenvironment by limiting the passage of molecules into the brain. BBB is formed by closely conjugated endothelial cells, with astrocytic endfeet surrounded and extracellular matrix (ECM) consolidated. Numerous neurological diseases can cause disturbance of BBB, leading to brain edema and neurological dysfunctions. The low-density lipoprotein (LDL) receptor–related protein 1 (LRP-1), a member of the LDL receptor gene family, is involved in a lot of important processes in the brain under both physiological and pathological conditions. As a membrane receptor, LRP-1 interacts with a variety of ligands and mediates the internalization of several important substances. LRP-1 is found responsible for inducing the opening of BBB following ischemic attack. It has also been reported that LRP-1 regulates several tight junction proteins and mediates the clearance of major ECM-degrading proteinases. In this review, we briefly discussed the role of LRP-1 in regulating BBB integrity by modulating tight junction proteins, endothelial cells and the remodeling of ECM.

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