scholarly journals P278 Comparison of prostaglandin E–major urinary metabolite (PGE-MUM) with faecal calprotectin and faecal immunochemical tests for determining endoscopic remission in patients with ulcerative colitis

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S290-S290
Author(s):  
T Sakurai ◽  
A Yoshihiro ◽  
M Haruna ◽  
M Ryosuke ◽  
M Yuki ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Receiver Operating Characteristics ◽  
Urinary Metabolite ◽  
Prostaglandin E ◽  
Operating Characteristics ◽  
Faecal Calprotectin ◽  
Major Urinary Metabolite ◽  
Endoscopic Remission ◽  
Remission Phase ◽  
Receiver Operating

Abstract Background Faecal calprotectin (FC) and faecal immunochemical tests (FIT) have the disadvantage of requiring faecal samples. It has been reported that prostaglandin E–major urinary metabolite (PGE-MUM) values correlate with Mayo endoscopic scores (MESs) for ulcerative colitis (UC). However, there has been no report that PGE-MUM can determine endoscopic remission under remission phase UC, nor comparative study of PGE-MUM with FC and FIT. Thus, we aimed to examine the association between PGE-MUM values and the colonoscopy (CS) results of patients in the remission phase of UC, and to compare the accuracy of using PGE-MUM vs. that of using FC or FIT values for determining endoscopic remission. Methods Patients diagnosed with UC who were under clinical remission and had planned to undergo CS from August 2017 to March 2019 were enrolled. FC levels were measured and FITs were performed on the day of CS; PGE-MUM was measured either the day before or after CS. Three physicians independently scored the CS findings (MES, Modified Mayo Endoscopic Score [MMES], and UC endoscopic index of severity [UCEIS]) while blinded from clinical information. We analysed the differences in PGE-MUM values between two groups, which were divided between those that did achieve and those that did not achieve the following scores: (1) MES 0 point, (2) MES 1 point, (3) modified MES 0 point, (4) modified MES ≤1 point, (5) UCEIS 0 point, (6) UCEIS ≤2 points. In addition, the accuracy of PGE-MUM, FC, and FIT with respect to determining the achievement of (1) through (6) were compared by using areas under the receiver operating characteristics curves. Patients with altered UC activity between the day of PGE-MUM measurement and CS, and those who received NSAIDs on the day of PGE-MUM measurement, were excluded from the analysis. Results Of the 125 enrolled subjects, 30 patients were excluded (urine specimens not submitted, 11; poor stool specimens, 6; NSAIDs users, 10; clearly altered UC activity, 3). The remaining 95 patients (average age 48.2 years, 57 males, and 54 patients with total colitis type), were eligible for analysis. The median PGE-MUM values (in µg/g·Cr) for groups that did or did not achieve (1) through (6) were as follows: (1) 14.6/17.2, p = 0.106; (2) 14.9/20.5, p = 0.039; (3) 14.5/17.4, p = 0.059; (4) 14.1/21.8, p < 0.001; 5) 14.5/17.4, p = 0.059; (6) 14.7/22.2, p = 0.003. The areas under the receiver operating characteristics curves for PGE-MUM/FC/FIT used for determining the achievement of 1) through 6) were as follows: (1) 0.597/0.664/0.682, (2) 0.692/0.74/0.825, (3) 0.613/0.686/0.692, (4) 0.794/0.82/0.786, (5) 0.613/0.686/0.692 and (6) 0.778/0.824/0.825. Conclusion PGE-MUM is equally as effective as FC and FIT for determining the achievement of endoscopic remission.

Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity

2017 ◽  
Vol 64 (6) ◽  
pp. 955-961 ◽  
Author(s):  
Shin-ichiro Hagiwara ◽  
Isao Okayasu ◽  
Mutsunori Fujiwara ◽  
Masaaki Matsuura ◽  
Hiromitsu Ohnishi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Urinary Metabolite ◽  
Prostaglandin E ◽  
Major Urinary Metabolite

scholarly journals Prostaglandin E-Major Urinary Metabolite Predicts Relapse in Patients With Ulcerative Colitis in Clinical Remission

2020 ◽  
Vol 11 (12) ◽  
pp. e00289
Author(s):  
Natsuki Ishida ◽  
Kiichi Sugiura ◽  
Takahiro Miyazu ◽  
Satoshi Tamura ◽  
Satoshi Suzuki ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Remission ◽  
Urinary Metabolite ◽  
Prostaglandin E ◽  
Major Urinary Metabolite

Prostaglandin E–Major Urinary Metabolite as a Reliable Surrogate Marker for Mucosal Inflammation in Ulcerative Colitis

2014 ◽  
Vol 20 (7) ◽  
pp. 1208-1216 ◽  
Author(s):  
Yoshinori Arai ◽  
Seiji Arihiro ◽  
Tomokazu Matsuura ◽  
Tomohiro Kato ◽  
Mika Matsuoka ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Surrogate Marker ◽  
Urinary Metabolite ◽  
Mucosal Inflammation ◽  
Prostaglandin E ◽  
Major Urinary Metabolite

scholarly journals Prostaglandin E-Major Urinary Metabolite as a Biomarker for Inflammation in Ulcerative Colitis: Prostaglandins Revisited

Digestion ◽  
2016 ◽  
Vol 93 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Yoshinori Arai ◽  
Tomokazu Matsuura ◽  
Masaaki Matsuura ◽  
Mutsunori Fujiwara ◽  
Isao Okayasu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Urinary Metabolite ◽  
Prostaglandin E ◽  
Major Urinary Metabolite

scholarly journals Comparison between Prostaglandin E-major urinary metabolite and C-reactive protein levels to reflect endoscopic scores in patients with ulcerative colitis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Natsuki Ishida ◽  
Satoshi Tamura ◽  
Takahiro Miyazu ◽  
Shinya Tani ◽  
Mihoko Yamade ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Significant Rise ◽  
Urinary Metabolite ◽  
Prostaglandin E ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Major Urinary Metabolite ◽  
Endoscopic Score ◽  
The Relationship ◽  
Over Time

AbstractProstaglandin E-major urinary metabolite (PGE-MUM) and C-reactive protein (CRP) are useful biomarkers in patients with ulcerative colitis. However, whether changes in endoscopic scores over time are reflected in the values of these biomarkers has not been verified. This prospective observational study aimed to assess the relationship between changes in biomarker levels and endoscopic scores in patients with ulcerative colitis. A total of 100 colonoscopy intervals of patients with ulcerative colitis were enrolled. The relationship between variations in the Mayo endoscopic subscore over time and the accompanying changes in biomarker values were investigated. PGE-MUM levels showed a significant rise in the increased endoscopic score group (P = 0.007) and a decrease with reduced endoscopic score group (P = 0.023). CRP levels showed a significant decline with lower endoscopic values (P < 0.001); however, there was no corresponding increase with higher endoscopic scores (P = 0.141). Biomarker levels remained unchanged with stable endoscopic scores (P = 0.090 and P = 0.705). PGE-MUM levels varied significantly, and corresponded to the mucosal healing state (P = 0.019 and P = 0.009). The correlation between changes in PGE-MUM and the endoscopic score was stronger than that for CRP (r = 0.518, P < 0.001 vs. r = 0.444, P < 0.001, respectively). PGE-MUM reflected changes in endoscopic scores more accurately than CRP.

Kriteriumsbezogene Cut-Off-Werte für Tätigkeitsspielraum und Arbeitsintensität

Diagnostica ◽  
2019 ◽  
Vol 65 (3) ◽  
pp. 179-190 ◽  
Author(s):  
Vincent Mustapha ◽  
Renate Rau
Keyword(s):  
Receiver Operating Characteristics ◽  
Operating Characteristics ◽  
Receiver Operating

Zusammenfassung. Cut-Off-Werte ermöglichen eine ökonomische, binäre Beurteilung von Summenscores. Für Beanspruchungsfragebögen, die personenbezogene Merkmale erfragen, sind Cut-Off-Werte häufig vorhanden und in der klinischen Diagnostik unerlässlich. Für die Bewertung von Arbeitsmerkmalen sind Cut-Off-Werte ebenfalls wünschenswert. Bislang fehlen sie jedoch für die Beurteilung von Arbeitsmerkmalen wie Arbeitsintensität und Tätigkeitsspielraum. Zwischen 2006 und 2016 wurden daher in verschiedenen Branchen 801 objektive Arbeitsplatzanalysen durchgeführt, welche eine Unterteilung in gut und schlecht gestalteten Tätigkeitsspielraum sowie gut und schlecht gestaltete Arbeitsintensität nach DIN EN ISO 6385 (2016) ermöglichen. Anhand dieser Unterteilung wurden mit der Receiver-Operating-Characteristics-Analyse Cut-Off-Werte für den subjektiv-bedingungsbezogen Fragebogen zum Erleben von Arbeitsintensität und Tätigkeitsspielraum (FIT; Richter et al., 2000 ) ermittelt. Für den Tätigkeitsspielraum weisen Summenscores ≤ 22 und für die Arbeitsintensität Summenscores ≥ 15 auf eine schlechte Gestaltung des jeweiligen Arbeitsmerkmals hin. Anhand einer weiteren Stichprobe von 1 076 Arbeitenden konnte gezeigt werden, dass Arbeitende mit schlecht gestaltetem Tätigkeitspielraum vital erschöpfter sowie weniger engagiert sind und Arbeitende mit schlecht gestalteter Arbeitsintensität eine höhere Erholungsunfähigkeit sowie vitale Erschöpfung aufweisen.

scholarly journals Arterial Digital Pulse Photoplethysmography in Patients with Suspected Thoracic Outlet Syndrome: A Study of the “Ca+Pra” Maneuver

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1128
Author(s):  
Jeanne Hersant ◽  
Pierre Ramondou ◽  
Francine Thouveny ◽  
Mickael Daligault ◽  
Mathieu Feuilloy ◽  
...  
Keyword(s):  
Thoracic Outlet Syndrome ◽  
Pulse Amplitude ◽  
Receiver Operating Characteristics ◽  
Upper Limbs ◽  
Operating Characteristics ◽  
Digital Pulse ◽  
Arterial Inflow ◽  
Receiver Operating

The level of pulse amplitude (PA) change in arterial digital pulse plethysmography (A-PPG) that should be used to diagnose thoracic outlet syndrome (TOS) is debated. We hypothesized that a modification of the Roos test (by moving the arms forward, mimicking a prayer position (“Pra”)) releasing an eventual compression that occurs in the surrender/candlestick position (“Ca”) would facilitate interpretation of A-PPG results. In 52 subjects, we determined the optimal PA change from rest to predict compression at imaging (ultrasonography +/− angiography) with receiver operating characteristics (ROC). “Pra”-PA was set as 100%, and PA was expressed in normalized amplitude (NA) units. Imaging found arterial compression in 23 upper limbs. The area under ROC was 0.765 ± 0.065 (p < 0.0001), resulting in a 91.4% sensitivity and a 60.9% specificity for an increase of fewer than 3 NA from rest during “Ca”, while results were 17.4% and 98.8%, respectively, for the 75% PA decrease previously proposed in the literature. A-PPG during a “Ca+Pra” test provides demonstrable proof of inflow impairment and increases the sensitivity of A-PPG for the detection of arterial compression as determined by imaging. The absence of an increase in PA during the “Ca” phase of the “Ca+Pra” maneuver should be considered indicative of arterial inflow impairment.

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