Differences in rates of percutaneous coronary intervention, cardiac surgery and all-cause mortality in indigenous and non-indigenous Australians with suspected acute coronary events

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
H.M.H Su ◽  
K Kang ◽  
N.A Seton ◽  
S.R Gederts ◽  
Y.S Der ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Ventricular Dysfunction ◽  
Coronary Intervention ◽  
Valvular Disease ◽  
Cardiac Catheterisation ◽  
Indigenous Australians ◽  
Percutaneous Coronary ◽  
All Cause Mortality ◽  
Coronary Events

Abstract Background Indigenous populations globally are known to have lower revascularisation rates following acute coronary events and higher mortality partly due to inequitable access to specialised care like cardiac catheterisation. Whether these disparities persist when access is readily available is unclear. Purpose We compared the rates of percutaneous coronary intervention (PCI), cardiac surgery, 30-day and long-term all-cause mortality in Indigenous (Aboriginal and Torres Strait Islanders) and non-Indigenous Australians in Far North Queensland (FNQ) – a region with a large Indigenous population and 24/7 cardiac catheterisation facilities. Method All public patients in FNQ having their first inpatient angiogram from November 2012 to October 2019 were identified. The primary study outcomes were rates of PCI or cardiac surgery and all-cause mortality at 30 days and long term. Secondary study outcomes were significant left ventricular dysfunction (ejection fraction <50%) and valvular disease (moderate to severe) in the echocardiogram subset. Other differences in baseline characteristics, including age, gender, body mass index, postcode and indication for angiography were accounted for using logistic and cox regression analysis. Results We identified 4489 patients (mean age, 61.7±13.0 years, 64.9% male, median follow-up 1045 days). 1042 (23.2%) self-identified as Indigenous. Indigenous patients were younger (53.7±11.6 vs 64.1±12.5 years, p<0.001), more likely female (45.5% vs 32.0%, p<0.001) and had small differences in angiography indications, ST elevation myocardial infarction (STEMI) 19.1% vs 18.1%, non-STEMI 45.7% vs 41.8%, angina 26.3% vs 28.0%, cardiac arrest 3.1% vs 3.7% and other 5.8% vs 8.4%, p=0.02. Rates of PCI or surgery 35.6% vs 38.5%, p=0.17, 30-day mortality 1.9% vs 2.7%, p=0.17 and long-term mortality 11.0% vs 11.5%, p=0.71 were similar in unadjusted data. 2959 patients (mean age, 62.1±13.0 years, 23.1% Indigenous, 64.9% male) were included in the echocardiogram subgroup. In unadjusted data Indigenous patients had similar rates of ventricular dysfunction 33.3% vs 31.3%, p=0.33 and valvular disease 19.4% vs 19.3%, p=0.93. After adjustment for other baseline characteristics, Indigenous patients had higher rates of PCI or cardiac surgery, OR 1.39 (95% CI, 1.18–1.64, p<0.001), ventricular dysfunction, OR 1.31 (95% CI, 1.07–1.60), p=0.01 and valvular disease, OR 1.93 (95% CI, 1.50–2.48), p<0.001. 30-day mortality was similar but Indigenous patients had higher adjusted long-term hazard of mortality, HR 1.80 (95% CI, 1.42–2.27), p<0.001. Conclusion When cardiac catheterisation was readily available Indigenous patients had higher rates of PCI and cardiac surgery and similar 30-day mortality to non-Indigenous patients. Equitable access to healthcare improves outcomes but the nearly double long-term mortality of Indigenous patients shows more is required to help close the gap for disadvantaged populations. Funding Acknowledgement Type of funding source: None

Gender differences in rates of percutaneous coronary intervention, cardiac surgery and valvular disease in indigenous Australians with suspected acute coronary events

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
H.M.H Su ◽  
K Kang ◽  
Y.S Der ◽  
J.D.S Millhouse ◽  
N.A Seton ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Ventricular Dysfunction ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Indigenous Women ◽  
Valvular Disease ◽  
Cardiac Catheterisation ◽  
All Cause Mortality ◽  
Coronary Events

Abstract Background Indigenous populations globally have a higher burden of cardiovascular disease and increased mortality after acute coronary events, partly due to inequitable access to specialised care like cardiac catheterisation. Gender differences in revascularisation rates have been well described in non-Indigenous patients. Whether this applies to Indigenous patients when cardiac catheterisation facilities are readily available is unclear. Purpose We compared the rates of percutaneous coronary intervention (PCI), cardiac surgery, 30-day and long-term all-cause mortality in Indigenous (Aboriginal and Torres Strait Islanders) patients in Far North Queensland (FNQ) – a region with a large Indigenous population and 24/7 cardiac catheterisation facilities. Method All patients who presented to the tertiary referral center for FNQ, for their first inpatient angiogram between November 2012 and October 2019 were identified. The primary study outcomes were rates of PCI or cardiac surgery and all-cause mortality measured at 30 days and long term. Secondary study outcomes were significant left ventricular dysfunction (ejection fraction <50%) and valvular disease (moderate to severe) in patients who had an echocardiogram. Other differences in baseline characteristics, including age, gender, body mass index, postcode and indication for angiography were accounted for using logistic and cox regression analysis. Results 1042 patients (mean age 53.7±11.6 years, 45.5% female, median follow-up 1092 days) self-identified as Indigenous. Indigenous women were older 54.8±11.4 vs 52.8±11.7 years, p=0.005 and had different angiography indications. For Indigenous women and men respectively, rates of ST elevation myocardial infarction (STEMI) were 14.6% vs 22.9%, non-STEMI 44.3% vs 46.8%, angina 32.7% vs 21.0%, cardiac arrest 2.7% vs 3.3% and other 5.7% vs 6.0%, p<0.001. Indigenous women had significantly lower rates of PCI or cardiac surgery, 40.5% vs 60.7%, p<0.001, but similar 30-day mortality, 1.5% vs 2.3% p=0.34 and long-term all-cause mortality rates 11.2% vs 10.9%, p=0.89, in unadjusted data. 685 patients (mean age 53.8±11.5 years, 45.5% female) were included in the echocardiogram subgroup. Indigenous women had significantly more valvular disease, 23.3% vs 16.3%, p=0.022 but similar rates of left ventricular dysfunction, 30.2% vs 35.8%, p=0.12. Following adjustment for other baseline characteristics female gender independently predicted lower rates of PCI or cardiac surgery, OR 0.49 (95% CI 0.38–0.64) and higher rates of valvular disease, OR 1.60 (95% CI 1.07–2.39). Rates of ventricular dysfunction, 30-day and long-term all-cause mortality were similar. Conclusions Indigenous women had significantly different indications for angiography, lower rates of PCI or cardiac surgery and higher rates of clinically significant valvular disease despite presenting in gender ratios similar to the general population in FNQ. Funding Acknowledgement Type of funding source: None

scholarly journals Treatment and Prognosis of Myocardial Infarction Outside Cardiology Departments

2020 ◽  
Vol 10 (1) ◽  
pp. 106
Author(s):  
Anton Gard ◽  
Bertil Lindahl ◽  
Nermin Hadziosmanovic ◽  
Tomasz Baron
Keyword(s):  
Myocardial Infarction ◽  
Coronary Intervention ◽  
Cardiology Department ◽  
Percutaneous Coronary ◽  
All Cause Mortality ◽  
Short And Long Term ◽  
Long Term Prognosis ◽  
One Year

Aim: Our aim was to investigate the characteristics, treatment and prognosis of patients with myocardial infarction (MI) treated outside a cardiology department (CD), compared with MI patients treated at a CD. Methods: A cohort of 1310 patients diagnosed with MI at eight Swedish hospitals in 2011 were included in this observational study. Patients were followed regarding all-cause mortality until 2018. Results: A total of 235 patients, exclusively treated outside CDs, were identified. These patients had more non-cardiac comorbidities, were older (mean age 83.7 vs. 73.1 years) and had less often type 1 MIs (33.2% vs. 74.2%), in comparison with the CD patients. Advanced age and an absence of chest pain were the strongest predictors of non-CD care. Only 3.8% of non-CD patients were investigated with coronary angiography and they were also prescribed secondary preventive pharmacological treatments to a lesser degree, with only 32.3% having statin therapy at discharge. The all-cause mortality was higher in non-CD patients, also after adjustment for baseline parameters, both at 30 days (hazard ratio (HR) 2.28; 95% confidence interval (CI) 1.62–3.22), one year (HR 1.82; 95% CI 1.39–2.36) and five years (HR 1.62; 95% CI 1.32–1.98). Conclusions: MI treatment outside CDs is associated with an adverse short- and long-term prognosis. An improved use of percutaneous coronary intervention (PCI) and secondary preventive pharmacological treatment might improve the long-term prognosis in these patients.

Prognostic Impact of Red Cell Distribution Width on the Development of Contrast Induced Nephropathy, Major Adverse Cardiac Events, and Mortality in Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention.

2021 ◽  
Vol 17 ◽  
Author(s):  
Azka Latif ◽  
Muhammad Junaid Ahsan ◽  
Noman Lateef ◽  
Vikas Kapoor ◽  
Hafiz Muhammad Fazeel ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Intervention ◽  
Cardiac Events ◽  
Distribution Width ◽  
Adverse Cardiac Events ◽  
Percutaneous Coronary ◽  
All Cause Mortality ◽  
Artery Disease

: Red cell distribution width (RDW) serves as an independent predictor towards the prognosis of coronary artery disease (CAD) in patients undergoing percutaneous coronary intervention (PCI). A systematic search of databases such as PubMed, Embase, Web of Science, and Cochrane library was performed on October 10th, 2019 to elaborate the relationship between RDW and in hospital and long term follow up all-cause and cardiovascular mortality, major adverse cardiac events (MACE) and development of contrast-induced nephropathy (CIN) in patients with CAD undergoing PCI. Twenty-one studies qualified this strict selection criteria (number of patients = 56,425): one study was prospective, and the rest were retrospective cohorts. Our analysis showed that patients undergoing PCI with high RDW had a significantly higher risk of in-hospital all-cause mortality (OR 2.41), long-term all-cause mortality (OR 2.44), cardiac mortality (OR 2.65), MACE (OR: 2.16) and odds of developing CIN (OR: 1.42) when compared to the patients with low RDW. Therefore, incorporating RDW in the predictive models for the development of CIN, MACE, and mortality can help in triage to improve the outcomes in coronary artery disease patients who undergo PCI.

scholarly journals Discharge Hemoglobin Association with Long-Term Outcomes of ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Ming Gao ◽  
Xinying Zhang ◽  
Ling Qin ◽  
Yang Zheng ◽  
Zhiguo Zhang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Primary Percutaneous Coronary Intervention ◽  
Bleeding Event ◽  
Coronary Intervention ◽  
Minor Bleeding ◽  
Percutaneous Coronary ◽  
All Cause Mortality ◽  
Lower Discharge

Background. Anemia following acute myocardial infarction (AMI) is associated with poor outcomes. While previous studies in patients with AMI have focused on anemia at admission, we hypothesized that hemoglobin (Hb) decline during hospitalization and lower discharge Hb would be associated with greater long-term mortality in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods. We analyzed records of 983 STEMI patients who were treated with primary PCI. The primary end point was all-cause mortality at 1 year and 2 years. The relationship between discharge Hb levels, decline in Hb levels, bleeding event classification, and all-cause mortality was determined. Results. Overall, 16.4% of patients had bleeding events, which were classified by the Thrombolysis in Myocardial Infarction (TIMI) score as 7% minimal, 8.6% minor, and 0.9% major. No significant gastrointestinal bleed and cerebral hemorrhage occurred in hospitals among these patients. The incidence rate of the 2-year all-cause mortality increased with severity of the bleeding event score (8.78% for no bleeding vs. 11.59% for minimal bleeding vs. 20.24% for minor bleeding vs. 55.56% for major bleeding, P<0.001). Discharge Hb was significantly associated with 2-year mortality in an unadjusted model (hazard ratio (HR) per 1 g/L decrease in discharge Hb = 1.020, 95% confidence interval (CI): 1.006–1.034, P=0.004) and in a confounder-adjusted model (HR per 1 g/L decrease in discharge Hb = 1.024, 95% CI: 1.011–1.037, P<0.001). The odds ratio (OR) for all-cause mortality at 2 years for participants with Hb below the twentieth percentile was 3.529 (95% CI: 1.976–6.302) and 2.968 (95% CI: 1.614–5.456) after adjustment for age and gender and 2.485 (95% CI: 1.310–4.715) after adjustment for all covariates. Conclusions. In this population of patients hospitalized for STEMI, all-cause mortality increased with lower discharge Hb, and discharge Hb was a significant predictor of mortality risk.

scholarly journals Long-term impact of baseline anaemia on clinical outcomes following percutaneous coronary intervention in stable angina

Open Heart ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. e001319
Author(s):  
Line Davidsen ◽  
Kristian Hay Kragholm ◽  
Mette Aldahl ◽  
Christoffer Polcwiartek ◽  
Christian Torp-Pedersen ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Clinical Outcomes ◽  
Stable Angina ◽  
Coronary Intervention ◽  
Coronary Syndrome ◽  
Percutaneous Coronary ◽  
All Cause Mortality ◽  
The Impact

BackgroundIn patients with stable angina (SA), the clinical benefits of percutaneous coronary intervention (PCI) reside almost exclusively within the realm of symptomatic improvement rather than improvement in hard clinical endpoints. The benefits of PCI should always be balanced against its potential short-term and long-term risks. Common among these risks is the presence of anaemia and its interaction with poor clinical outcomes and increased morbidity; this study aims to elucidate the impact of anaemia on long-term clinical outcomes of this patient group.MethodsFrom Danish national registries, we identified patients with SA treated with PCI who had a haemoglobin measurement maximum of 90 days prior to PCI procedure. Anaemia was defined as haemoglobin <130 and <120 g/L in men and women, respectively. Follow-up was up to 3 years after PCI, and Cox regression was used to estimate HRs with 95% CIs of hospitalisation due to bleeding, acute coronary syndrome (ACS) and all-cause mortality in patients with anaemia compared with patients without anaemia.ResultsOf 2837 included patients, 14.6% had anaemia prior to PCI. During follow-up, 93 patients (3.3%) had a bleeding episode, which was higher in patients with anaemia (5.8%) compared with patients without anaemia (2.8%). A total of 213 patients (7.5%) developed ACS, which was higher in patients with anaemia (10.6%) compared with patients without anaemia (7.0%). Furthermore, 185 patients (6.5%) died, with a mortality rate of 18.1% in patients with anaemia compared with 4.5% in patients without anaemia. In multivariable analyses, anaemia was associated with a significantly increased risk of bleeding (HR 1.69; 95% CI 1.04 to 2.73; P 0.033), ACS (HR 1.47; 95% CI 1.04 to 2.10; P 0.031) and all-cause mortality (HR 2.41; 95% CI 1.73 to 3.30; P <0.001).ConclusionAnaemia in patients with SA was significantly associated with bleeding, ACS and all-cause mortality following PCI.

Prognostic Value of Admission Blood Urea Nitrogen/Creatinine Ratio in Patients with STEMI Undergoing Late Percutaneous Coronary Intervention

2021 ◽  
Author(s):  
Caijuan Dong ◽  
Yanbo Xue ◽  
Yan Fan ◽  
Ruochen Zhang ◽  
Yunfei Feng ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Blood Urea Nitrogen ◽  
Independent Predictor ◽  
Coronary Intervention ◽  
Creatinine Ratio ◽  
Cardiac Mortality ◽  
Urea Nitrogen ◽  
Percutaneous Coronary ◽  
All Cause Mortality

Abstract Objective: Numerous patients with ST-segment elevation myocardial infarction (STEMI), especially in developing countries, undergo late percutaneous coronary intervention (PCI), defined as time of PCI > 24 hours from symptom onset. This study is aimed to identify the predictive value of admission blood urea nitrogen/creatinine ratio (BUN/Cr) on long-term all-cause mortality and cardiac mortality in STEMI patients receiving late PCI. Methods: Eligible STEMI patients who received late PCI between 2009 and 2011 were consecutively enrolled. They were classified into two groups based on the median BUN/Cr: low BUN/Cr group and high BUN/Cr group. Patients were followed up by phone or face to face interviews and medical records review. The primary endpoint was defined as all-cause mortality and cardiac mortality. Results: 780 STEMI patients were enrolled finally. The median BUN/Cr was 14.29. The median follow-up period was 41 months, with 37 all-cause deaths and 25 cardiac deaths. Compared to the low BUN/Cr group, high BUN/Cr group had higher all-cause mortality (6.4% vs. 3.1%, P=0.029), and cardiac mortality (6.3% vs. 1.5%, P<0.001). The Cox proportional hazard analysis revealed that high BUN/Cr at admission was an independent predictor of long-term cardiac mortality (P=0.003), but not of all-cause mortality (P=0.077). Conclusions: High BUN/Cr ratio at admission was an independent predictor of cardiac mortality in STEMI patients receiving late PCI. Brief Summary: In a retrospective study of STEMI patients receiving late PCI, we found that high BUN/Cr ratio (BUN/Cr>14.29) at admission was an independent predictor of long-term cardiac mortality, but not of all-cause mortality. The study showed that BUN/Cr ratio could be a potential indicator of risk stratification models for STEMI patients undergoing late PCI.

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