Long-term effects of the Herbst appliance in relation to the treatment growth period: a cephalometric study

1991 ◽  
Vol 13 (6) ◽  
pp. 471-481 ◽  
Author(s):  
K. Hansen ◽  
H. Pancherz ◽  
U. Hagg
1995 ◽  
Vol 22 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Ken Hansen ◽  
Pannamas Iemamnueisuk ◽  
Hans Pancherz

The purpose of this study was to evaluate biometrically the treatment and post-treatment effects of the Herbst appliance on the dental arches and arch relationships. The sample consisted of 53 Class II, division 1 malocclusion patients (33 boys and 20 girls) treated with the Herbst appliance. The mean age of the patients before treatment was 12·5 years (SD = 1·2 years). Dental casts were analysed before treatment, after treatment, 6 months post-treatment and at the end of the growth period (5–10 years post-treatment). The following variables were assessed: sagittal molar and canine relationships, overjet, overbite, maxillary and mandibular arch perimeters, and inter-molar and inter-canine dental arch widths. During treatment, the overjet, overbite, and sagittal molar relationship were overcorrected in most of the cases, while the sagittal canine relationship was normalized. The maxillary and mandibular arch perimeters increased during treatment, as did dental arch widths (moral and canine). In the long-term (mean = 6·7 years after treatment), Herbst appliance treatment resulted in a normal or over-corrected sagittal molar relationship in 79 per cent and a normal canine relationship in 68 per cent of the cases. Eighty-three per cent of the subjects has an overjet of 4·5 mm or less. In the long-term, the arch perimeters seemed to follow a normal dental development pattern. The increase of the upper molar and canine dental arch widths during treatment remained virtually stable whilst the lower intermolar arch widths seemed unaffected by treatment.


2000 ◽  
Vol 2000 ◽  
pp. 120-120 ◽  
Author(s):  
R. D. Slade ◽  
H. M. Miller

Porcine plasma is known to improve immediate post-weaning performance but this is often only evident in the first week to ten days after weaning (Toplis and Miller, 1999). Few if any studies have investigated whether there are any long term effects over the entire growth period. It has previously been shown that piglets in poor health situations (Coffey and Cromwell, 1995) demonstrate markedly greater responses to porcine plasma. The objective of this study was to determine whether porcine plasma produced long-term benefits and whether this was modulated by health challenge during the weaning period.


2008 ◽  
Vol 275 (1642) ◽  
pp. 1565-1570 ◽  
Author(s):  
François Criscuolo ◽  
Pat Monaghan ◽  
Lubna Nasir ◽  
Neil B Metcalfe

Resting metabolic rate (RMR) is responsible for up to 50% of total energy expenditure, and so should be under strong selection pressure, yet it shows extensive intraspecific variation and a low heritability. Environmental conditions during growth are thought to have long-term effects through ‘metabolic programming’. Here we investigate whether nutritional conditions early in life can alter RMR in adulthood, and whether this is due to growth acceleration or the change in diet quality that prompts it. We manipulated dietary protein levels during the main growth period of zebra finches ( Taeniopygia guttata ) such that an episode of poor nutrition occurred with and without growth acceleration. This produced different growth trajectories but a similar adult body mass. Only the diet that induced growth acceleration resulted in a significant (19%) elevation of RMR at adulthood, despite all the birds having been on the same diet after the first month. This is the first study to show that dietary-induced differences in growth trajectories can have a long-term effect on adult metabolic rate. It suggests that modification of metabolic efficiency may be one of the mechanisms mediating the observed long-term costs of accelerated growth, and indicates links between early nutrition and the metabolic syndrome.


2021 ◽  
Author(s):  
Michele Ori ◽  
Giampietro Ricci ◽  
Maria Capalbo ◽  
Massimo Maranzano ◽  
Antonio Sarno ◽  
...  

Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.


Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.


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