Genetic polymorphisms of interleukin-6 and interleukin-10 are not associated with new onset atrial fibrillation after coronary artery bypass graft surgery

Abstract Purpose To estimate the association of the genetic polymorphisms of Interleukin-6 (IL-6) and Interleukin-10 (IL-10) with new onset atrial fibrillation (AF) in postoperative period of coronary artery bypass graft (CABG) surgery in patients with coronary artery disease (CAD). Methods Studied were 158 patients who underwent CABG. In all the patients routine laboratory and instrumental tests were performed. Patients also underwent genetic polymorphisms of IL-6 C174G, IL-10 C592A and IL-10 G1082A estimation. All the patients were divided into two groups: 1 group comprised 111 patients without AF (82.0% men, median age 62.0 (56.0; 66.0) years, 2 group - 47 patients with AF development after CABG (84.4% men, median age 65.0 (61.0; 70.0) years). Results During the observation period AF occurred in 29.7% patients, on average 5.2 (2.0; 7.0) days after surgery. Patients of group 2 had longer history of CAD (60.0 (13.5; 138.0) vs. 15.5 (8.0; 72.0) months, p=0.01), had more often NYHA III class (27.7% vs. 9.0%, p=0.002) and larger left atrial (LA) diameter (44.0 (40.5; 46.0) mm vs. 38.0 (36.0; 40.0) mm, p<0.0001) comparing with group 1. Genotype CC IL-6 C174G was found in 19.8% patients of the 1 group and in 25.5% patients of the 2 group (p=0.42), genotype CG - in 56.8% and 53.2% (p=0.68), genotype GG - in 23.4% and 21.3% (p=0.77) respectively. Genotype CC IL-10 C592A was found in 62.2% patients of the 1 group and 46.8% patients of the 2 group (p=0.29), genotype CA - in 37.8% patients of the 1 group and in 53.2% patients of the 2 group (p=0.07) respectively. Genotype GG IL-10 G1082A was found in 25.2% patients of the 1 group and 23.4% patients of the 2 group (p=0.8), genotype GA - in 48.6% patients of the 1 group and in 59.6% patients of the 2 group (p=0.2), genotype AA - in 26.2% patients of the 1 group and in 17.0% patients of the 2 group (p=0.3) respectively. All estimated genotypes fulfilled expectations of Hardy-Weinberg equilibrium. According to the result of multivariate regression analysis the odds ratio for AF development in postoperative period of CABG for history of CAD more than 20 months - 1.1 (95% CI, 1.03–1.2, p=0.04), for LA dimension more than 41 mm - 1.5 (95% CI, 1.28–1.79, p<0.0001). Conclusion Our investigation showed that increased left atrial dimension and the history of coronary artery disease were associated with postoperative atrial fibrillation development in patients who underwent coronary artery bypass graft surgery. However, genetic polymorphisms of IL-6 C174G, IL-10 C592A and IL-10 G1082A were not significantly associated with postoperative atrial fibrillation development. FUNDunding Acknowledgement Type of funding sources: None.

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Echocardiography is useful to predict postoperative atrial fibrillation in patients undergoing isolated coronary bypass surgery: A prospective study

European Heart Journal Acute Cardiovascular Care ◽

10.1177/2048872616688419 ◽

2017 ◽

Vol 8 (2) ◽

pp. 104-113 ◽

Cited By ~ 3

Author(s):

Julien Magne ◽

Baptiste Salerno ◽

Dania Mohty ◽

Claire Serena ◽

Florence Rolle ◽

...

Keyword(s):

Atrial Fibrillation ◽

Coronary Artery ◽

Coronary Artery Bypass Graft ◽

Coronary Artery Bypass ◽

Left Atrial ◽

Artery Bypass ◽

Bypass Graft ◽

Postoperative Atrial Fibrillation ◽

Artery Bypass Graft ◽

History Of

Objective: Postoperative atrial fibrillation is a major complication following coronary artery bypass graft. We hypothesized that, beyond clinical and electrocardiogram (ECG) data, transthoracic echocardiography could improve the prediction of postoperative atrial fibrillation. Methods: We prospectively studied 169 patients in sinus rhythm who underwent isolated coronary artery bypass graft in our institution. Clinical, biological, ECG and transthoracic echocardiography data were collected within 24 h before surgery. The patients were continuously monitored during the first five days, and then had daily 12-lead ECG afterwards until discharge. Postoperative atrial fibrillation was defined by any episode >10 min. Results: Postoperative atrial fibrillation was found in 65 patients (38%). Compared with those without, patients with postoperative atrial fibrillation were significantly older ( p=0.008), had more frequently a history of hypertension ( p=0.009), history of atrial fibrillation ( p<0.001) and New York Heart Association class ⩾III ( p=0.004). They also had longer PR interval ( p=0.005), higher preoperative NT-pro brain natriuretic peptide level ( p=0.006), left ventricle end-diastolic volume ( p=0.002), indexed left ventricle mass ( p<0.0001), indexed maximal left atrial volume ( p<0.0001), maximal right atrial area ( p<0.001) and lower left ventricle ejection fraction ( p=0.04). In multivariate analysis, history of atrial fibrillation (odds ratio =6.1, 95% confidence interval: 1.4–26.0, p=0.02) and indexed maximal left atrial volume (odds ratio =1.13, 95% confidence interval: 1.1–1.2, p=0.001) were the only two independent predictive factors of postoperative atrial fibrillation. The addition of echocardiographic parameters improved the predictive value (χ2) of the model, from 34 to 57. Conclusion: A history of atrial fibrillation and indexed left atrial maximal volume are the best predictors of the occurrence of postoperative atrial fibrillation following coronary artery bypass graft. The identification of high risk population of postoperative atrial fibrillation using these two factors could lead to the development of targeted strategies to limit this frequent complication in these patients.

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