scholarly journals Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide

2008 ◽  
Vol 29 (11) ◽  
pp. 1424-1431 ◽  
Author(s):  
L. M.J.W. van Driel ◽  
H. P.M. Smedts ◽  
W. A. Helbing ◽  
A. Isaacs ◽  
J. Lindemans ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Increased Risk

scholarly journals The incidence and diagnostics of congenital heart defects in Kaunas infant population during 1999–2005

Medicina ◽  
2008 ◽  
Vol 44 (2) ◽  
pp. 139
Author(s):  
Virginija Dulskienë ◽  
Vilija Malinauskienë ◽  
Ada Azaravièienë ◽  
Renata Kuèienë
Keyword(s):  
Birth Weight ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Epidemiological Methods ◽  
Normal Birth ◽  
Congenital Heart Malformations ◽  
Increased Risk ◽  
Heart Malformation ◽  
Heart Malformations

The objective of this study was to determinate the incidence and diagnostics of congenital heart defects in Kaunas infant population in 1999–2005 and to compare the data obtained with the data of years 1995–1998. Subject and methods. The study population comprised all newborns born in Kaunas city during 1999– 2005. Congenital heart defects were registered based on clinical diagnosis after its verification using the data from consulting centers and pediatric outpatient departments. To assess the incidence of congenital heart malformations in newborn population, we conducted a validated newborn register based on maternal residential district. Modern epidemiological methods were used for data analysis. Results. In 1999–2005, there were 24 069 live births in Kaunas: 2231 newborns were born with congenital anomalies, 198 had congenital heart malformations. The incidence of congenital heart defects was 8.2 per 1000 live newborns. The majority of congenital heart malformations were diagnosed in delivery units (93.94%). We have analyzed the relationship between birth weight and gestational age of newborns with congenital heart malformations. Newborns with low birth weight were at significantly higher risk of congenital heart malformation than newborns with normal birth weight (OR=3.52, 95% CI, 2.25–5.47). Our data also showed that newborns born before 32 weeks of gestation had a 5-fold increased risk of congenital heart malformation (OR=5.20; 95% CI, 2.50–10.84) and infants born before 37 weeks of gestation had a 4-fold increased risk (OR=4.08; 95% CI, 2.68–6.19) compared with newborns born after 37 weeks of gestation. Conclusions. This study shows that incidence of congenital heart anomalies in Kaunas newborn population was 8.2 cases per 1000 live newborns in 1999–2005. It was determined that during 1999–2005, the number of above-mentioned anomalies diagnosed in delivery units increased by 23%.

scholarly journals Maternal Obesity and the Risk of Congenital Heart Defects: the Mediation Effect of Pregestational Diabetes

2021 ◽  
Author(s):  
Xiao-Xia Wu ◽  
Ru-Xiu Ge ◽  
Le Huang ◽  
Fu-Ying Tian ◽  
Yi-Xuan Chen ◽  
...  
Keyword(s):  
Risk Factor ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Maternal Education ◽  
Maternal Obesity ◽  
Heart Defects ◽  
Normal Weight ◽  
Mediation Effect ◽  
Pregestational Diabetes ◽  
Increased Risk

Abstract Background Congenital heart defects (CHDs) are the most common birth defects worldwide. Maternal obesity has been proposed as a risk factor for CHDs, but the results are controversial and inconclusive. Pregestational diabetes (PGDM) is well known as a risk factor for CHDs and is closely related to obesity. However, the effect of PGDM on the association between maternal obesity and CHDs has not been investigated.Objectives We aimed to explore the association between maternal obesity and CHDs and to further evaluate the mediation effect of PGDM on this association.Methods We involved 53708 mother-infant pairs with deliveries between 2017 and 2019 from the Birth Cohort in Shenzhen (BiCoS). Mothers were categorized into four groups: the underweight group (BMI < 18.5), normal weight group (18.5 ≤ BMI < 24), overweight group (24 ≤ BMI < 28) and obesity group (BMI ≥ 28). To evaluate the association between BMI and CHDs, we fit multivariable logistic regression models, adjusting for maternal age, maternal education level, mode of conception, parity, GDM and offspring sex. Mediation analysis was used to confirm the mediation effect of PGDM on the association between maternal obesity and CHDs.Results The proportion of obese individuals in the BiCoS was 2.11%. Overall, 372 (0.69%) infants were diagnosed with CHDs. The prevalence of CHDs in underweight, normal weight, overweight and obese individuals was 0.64%, 0.68%, 0.72% and 1.24%, respectively. Maternal obesity was associated with an increased risk of CHDs (OR=1.97, 95% CI 1.14–3.41). The offspring of women with PGDM were 6.88 times (95% CI 4.11–11.53) more likely to have CHDs than the offspring of mothers without PGDM. The mediation effect of PGDM on the association between maternal obesity and CHDs was significant (OR=1.18, 95% CI 1.06–1.32). The estimated mediation proportion was 24.83%.Conclusion Our findings suggested that maternal obesity was associated with CHDs and that PGDM partially mediated the association between maternal obesity and CHDs.

High maternal selenium levels are associated with increased risk of congenital heart defects in the offspring

2019 ◽  
Vol 39 (12) ◽  
pp. 1107-1114
Author(s):  
Yixiong Guo ◽  
Ping Yu ◽  
Jun Zhu ◽  
Shuihua Yang ◽  
Jing Yu ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Increased Risk

Proximity of residence to trichloroethylene-emitting sites and increased risk of offspring congenital heart defects among older women

2004 ◽  
Vol 70 (10) ◽  
pp. 808-814 ◽  
Author(s):  
Jennifer S. Yauck ◽  
Marsha E. Malloy ◽  
Kathleen Blair ◽  
Pippa M. Simpson ◽  
D. Gail McCarver
Keyword(s):  
Older Women ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Increased Risk

scholarly journals Increased Risk for Non-Autoimmune Hypothyroidism in Young Patients with Congenital Heart Defects

2011 ◽  
Vol 96 (7) ◽  
pp. E1115-E1119 ◽  
Author(s):  
E. Passeri ◽  
M. Frigerio ◽  
T. De Filippis ◽  
R. Valaperta ◽  
P. Capelli ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Young Patients ◽  
Autoimmune Hypothyroidism ◽  
Increased Risk

Are Black and Hispanic Infants with Specific Congenital Heart Defects at Increased Risk of Preterm Birth?

2009 ◽  
Vol 30 (6) ◽  
pp. 800-809 ◽  
Author(s):  
Wendy N. Nembhard ◽  
Jason L. Salemi ◽  
Melissa L. Loscalzo ◽  
Tao Wang ◽  
Kimberlea W. Hauser
Keyword(s):  
Preterm Birth ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Increased Risk

scholarly journals Maternal obesity and metabolic disorders associate with congenital heart defects in the offspring: A systematic review

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252343
Author(s):  
Gitte Hedermann ◽  
Paula L. Hedley ◽  
Ida N. Thagaard ◽  
Lone Krebs ◽  
Charlotte Kvist Ekelund ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Gestational Diabetes ◽  
Cohort Studies ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Metabolic Disorders ◽  
Maternal Obesity ◽  
Heart Defects ◽  
Increased Risk ◽  
Maternal Overweight

Background Congenital heart defects (CHDs) are the most common congenital malformations. The aetiology of CHDs is complex. Large cohort studies and systematic reviews and meta-analyses based on these have reported an association between higher risk of CHDs in the offspring and individual maternal metabolic disorders such as obesity, diabetes, hypertension, and preeclampsia, all conditions that can be related to insulin resistance or hyperglycaemia. However, the clinical reality is that these conditions often occur simultaneously. The aim of this review is, in consequence, both to evaluate the existing evidence on the association between maternal metabolic disorders, defined as obesity, diabetes, hypertension, preeclampsia, dyslipidaemia and CHDs in the offspring, as well as the significance of combinations, such as metabolic syndrome, as risk factors. Methods A systematic literature search of papers published between January 1, 1990 and January 14, 2021 was conducted using PubMed and Embase. Studies were eligible if they were published in English and were case-control or cohort studies. The exposures of interest were maternal overweight or obesity, hypertension, preeclampsia, diabetes, dyslipidaemia, and/or metabolic syndrome, and the outcome of interest was CHDs in the offspring. Furthermore, the studies were included according to a quality assessment score. Results Of the 2,250 identified studies, 32 qualified for inclusion. All but one study investigated only the individual metabolic disorders. Some disorders (obesity, gestational diabetes, and hypertension) increased risk of CHDs marginally whereas pre-gestational diabetes and early-onset preeclampsia were strongly associated with CHDs, without consistent differences between CHD subtypes. A single study suggested a possible additive effect of maternal obesity and gestational diabetes. Conclusions Future studies of the role of aberrations of the glucose-insulin homeostasis in the common aetiology and mechanisms of metabolic disorders, present during pregnancy, and their association, both as single conditions and–particularly–in combination, with CHDs are needed.

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