scholarly journals The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study

2009 ◽  
Vol 31 (5) ◽  
pp. 602-613 ◽  
Author(s):  
A. Scuteri ◽  
S. S. Najjar ◽  
M. Orru' ◽  
G. Usala ◽  
M. G. Piras ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Men And Women ◽  
The Metabolic Syndrome

Childhood growth and future risk of the metabolic syndrome in normal-weight men and women

2009 ◽  
Vol 35 (2) ◽  
pp. 143-150 ◽  
Author(s):  
M.K. Salonen ◽  
E. Kajantie ◽  
C. Osmond ◽  
T. Forsén ◽  
H. Ylihärsilä ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Normal Weight ◽  
Men And Women ◽  
Childhood Growth ◽  
The Metabolic Syndrome ◽  
Future Risk

Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome

2005 ◽  
Vol 98 (1) ◽  
pp. 168-179 ◽  
Author(s):  
Dustin S. Hittel ◽  
William E. Kraus ◽  
Chuck J. Tanner ◽  
Joseph A. Houmard ◽  
Eric P. Hoffman
Keyword(s):  
Metabolic Syndrome ◽  
Lactate Dehydrogenase ◽  
Pyruvate Dehydrogenase ◽  
Oxidative Metabolism ◽  
Aspartate Aminotransferase ◽  
Aerobic Training ◽  
Exercise Intervention ◽  
Complex Iii ◽  
Men And Women ◽  
The Metabolic Syndrome

Aerobic conditioned muscle shows increased oxidative metabolism or glucose relative to untrained muscle at a given absolute exercise intensity. The studies of a targeted risk reduction intervention through defined exercise (STRRIDE) study is an aerobic exercise intervention in men and women with features of metabolic syndrome (Kraus WE, Torgan CE, Duscha BD, Norris J, Brown SA, Cobb FR, Bales CW, Annex BH, Samsa GP, Houmard JA, and Slentz CA, Med Sci Sports Exerc 33: 1774–1784, 2001), with four muscle biopsies taken during training and detraining time points. Here, we expanded a previous study (Hittel DS, Kraus WE, and Hoffman EP, J Physiol 548: 401–410, 2003) and used mRNA profiling to investigate gene transcripts associated with energy and substrate metabolism in STRRIDE participants. We found coordinate regulation of key metabolic enzymes with aerobic training in metabolic syndrome (aspartate aminotransferase 1, lactate dehydrogenase B, and pyruvate dehydrogenase-α1). All were also quickly downregulated by detraining, although the induction was not an acute response to activity. Protein and enzymatic assays were used to validate mRNA induction with aerobic training and loss with detraining (96 h to 2 wk) in 10 male and 10 female STRRIDE subjects. We propose that training coordinately increases the levels of aspartate aminotransferase 1, lactate dehydrogenase B, and pyruvate dehydrogenase-α1 subunit, increasing glucose metabolism in muscle by liberating pyruvate for oxidative metabolism and, therefore, limiting lactate efflux. Serial measurement of fasting plasma lactate from 62 subjects from the same exercise group demonstrated a significant decrease of circulating lactate with training. We also found evidence for sex-specific molecular remodeling of muscle with ubiquinol-cytochrome c reductase core protein II, a component of mitochondrial respiratory complex III, which showed an increase after training that was specific to women. These biochemical adaptations complement existing molecular models for improved glucose tolerance with exercise intervention in prediabetic individuals.

scholarly journals Association of Cortisol and the Metabolic Syndrome in Korean Men and Women

2011 ◽  
Vol 26 (7) ◽  
pp. 914 ◽  
Author(s):  
Sat Byul Park ◽  
James A. Blumenthal ◽  
Soon Young Lee ◽  
Anastasia Georgiades
Keyword(s):  
Metabolic Syndrome ◽  
Men And Women ◽  
The Metabolic Syndrome

Abstract P084: Associations of Anger and Hostility with the Metabolic Syndrome: Cross-sectional Analyses from the Jackson Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Janice E Williams ◽  
Sharon B Wyatt ◽  
Mario Sims ◽  
Thomas H Mosley ◽  
Patricia M Dubbert ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
African American ◽  
Disease Risk ◽  
African American Men ◽  
Cardiovascular Disease Risk ◽  
Continuous Variables ◽  
Jackson Heart Study ◽  
Men And Women ◽  
The Metabolic Syndrome ◽  
Heart Study

There is evidence that anger and hostility are positively associated with the metabolic syndrome. In turn, the metabolic syndrome mediates the association between anger and hostility and adverse cardiac events. Very little is known about these associations in African-American populations. We assessed the hypothesis that anger and hostility are positively associated with the metabolic syndrome in an African-American cohort. Participants were 2,732 African-American men and women, ages 45 – 95, who were enrolled in the Jackson Heart Study at baseline. Anger was measured using the Spielberger State-Trait Anger Inventory, and hostility was measured using the Cook-Medley Hostility Scale. The metabolic syndrome was defined by the National Cholesterol Education Program, Adult Treatment Panel III criteria. Overall anger, components anger-in and anger-out, and hostility scores were entered into separate logistic regression models as continuous variables. In models adjusted for age, sex, educational level, and physical activity, higher levels of overall anger (β = 0.024, p = 0.006), anger-in (β = 0.028, p = 0.04), anger-out (β = 0.037, p = 0.04), and hostility (β = 0.021, p = 0.04) were associated with an increased prevalence of the metabolic syndrome. The correlation between anger and hostility was statistically significant but not strong (r = 0.38, p <0.0001). In men, 5 of the 16 individual anger items were significantly associated with the metabolic syndrome. The strongest was “I lose my temper” (β = 0.395, p = 0.003) and “I tend to harbor grudges” (β = 0.314, p = 0.008). In women, only 1 anger item, “I make sarcastic remarks” (β = 0.189, p = 0.04) was associated with the metabolic syndrome. In conclusion, higher levels of overall anger, anger-in, anger-out, and hostility were associated with an increased prevalence of the metabolic syndrome in middle- and older-aged African-American men and women. In men, an angry temperament and a tendency to hold grudges were particularly strong correlates of the metabolic syndrome. Increased understanding of the negative emotions anger and hostility among African-Americans may provide greater insights into cardiovascular disease risk in their population.

Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and women

2009 ◽  
Vol 71 (5) ◽  
pp. 673-678 ◽  
Author(s):  
Tommy Ahlström ◽  
Emil Hagström ◽  
Anders Larsson ◽  
Claes Rudberg ◽  
Lars Lind ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Parathyroid Hormone ◽  
Plasma Calcium ◽  
Community Based ◽  
Men And Women ◽  
The Metabolic Syndrome

scholarly journals Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study

2007 ◽  
Vol 18 (10) ◽  
pp. 1337-1344 ◽  
Author(s):  
D. von Muhlen ◽  
S. Safii ◽  
S. K. Jassal ◽  
J. Svartberg ◽  
E. Barrett-Connor
Keyword(s):  
Metabolic Syndrome ◽  
Bone Health ◽  
Older Men ◽  
Men And Women ◽  
The Metabolic Syndrome ◽  
Older Men And Women

scholarly journals Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study

2007 ◽  
Vol 24 (4) ◽  
pp. 430-435 ◽  
Author(s):  
R. K. Schindhelm ◽  
J. M. Dekker ◽  
G. Nijpels ◽  
C. D. A. Stehouwer ◽  
L. M. Bouter ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Alanine Aminotransferase ◽  
Men And Women ◽  
The Metabolic Syndrome ◽  
Caucasian Men

scholarly journals Osteoarthritis and the metabolic syndrome: more evidence that the etiology of OA is different in men and women

2012 ◽  
Vol 20 (7) ◽  
pp. 603-604 ◽  
Author(s):  
K.M. Huffman ◽  
W.E. Kraus
Keyword(s):  
Metabolic Syndrome ◽  
Men And Women ◽  
The Metabolic Syndrome

scholarly journals Metabolic Factors and the Risk of Pancreatic Cancer: A Prospective Analysis of almost 580,000 Men and Women in the Metabolic Syndrome and Cancer Project

2010 ◽  
Vol 19 (9) ◽  
pp. 2307-2317 ◽  
Author(s):  
Dorthe Johansen ◽  
Tanja Stocks ◽  
Håkan Jonsson ◽  
Björn Lindkvist ◽  
Tone Björge ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Metabolic Syndrome ◽  
Prospective Analysis ◽  
Metabolic Factors ◽  
Men And Women ◽  
The Metabolic Syndrome ◽  
Cancer Project
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