scholarly journals Metabolic Factors and the Risk of Pancreatic Cancer: A Prospective Analysis of almost 580,000 Men and Women in the Metabolic Syndrome and Cancer Project

2010 ◽  
Vol 19 (9) ◽  
pp. 2307-2317 ◽  
Author(s):  
Dorthe Johansen ◽  
Tanja Stocks ◽  
Håkan Jonsson ◽  
Björn Lindkvist ◽  
Tone Björge ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Metabolic Syndrome ◽  
Prospective Analysis ◽  
Metabolic Factors ◽  
Men And Women ◽  
The Metabolic Syndrome ◽  
Cancer Project

scholarly journals Metabolic factors and the risk of colorectal cancer in 580,000 men and women in the metabolic syndrome and cancer project (Me-Can)

Cancer ◽  
2010 ◽  
Vol 117 (11) ◽  
pp. 2398-2407 ◽  
Author(s):  
Tanja Stocks ◽  
Annekatrin Lukanova ◽  
Tone Bjørge ◽  
Hanno Ulmer ◽  
Jonas Manjer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metabolic Syndrome ◽  
Metabolic Factors ◽  
Men And Women ◽  
The Metabolic Syndrome ◽  
Cancer Project

scholarly journals Metabolic factors and blood cancers among 578,000 adults in the metabolic syndrome and cancer project (Me-Can)

2012 ◽  
Vol 91 (10) ◽  
pp. 1519-1531 ◽  
Author(s):  
Gabriele Nagel ◽  
Tanja Stocks ◽  
Daniela Späth ◽  
Anette Hjartåker ◽  
Björn Lindkvist ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Factors ◽  
The Metabolic Syndrome ◽  
Cancer Project

Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can)

2011 ◽  
Vol 22 (5) ◽  
pp. 743-751 ◽  
Author(s):  
Martin Almquist ◽  
Dorthe Johansen ◽  
Tone Björge ◽  
Hanno Ulmer ◽  
Björn Lindkvist ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Thyroid Cancer ◽  
Metabolic Factors ◽  
The Metabolic Syndrome ◽  
Cancer Project

scholarly journals The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study

2009 ◽  
Vol 31 (5) ◽  
pp. 602-613 ◽  
Author(s):  
A. Scuteri ◽  
S. S. Najjar ◽  
M. Orru' ◽  
G. Usala ◽  
M. G. Piras ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Men And Women ◽  
The Metabolic Syndrome

Childhood growth and future risk of the metabolic syndrome in normal-weight men and women

2009 ◽  
Vol 35 (2) ◽  
pp. 143-150 ◽  
Author(s):  
M.K. Salonen ◽  
E. Kajantie ◽  
C. Osmond ◽  
T. Forsén ◽  
H. Ylihärsilä ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Normal Weight ◽  
Men And Women ◽  
Childhood Growth ◽  
The Metabolic Syndrome ◽  
Future Risk

Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome

2005 ◽  
Vol 98 (1) ◽  
pp. 168-179 ◽  
Author(s):  
Dustin S. Hittel ◽  
William E. Kraus ◽  
Chuck J. Tanner ◽  
Joseph A. Houmard ◽  
Eric P. Hoffman
Keyword(s):  
Metabolic Syndrome ◽  
Lactate Dehydrogenase ◽  
Pyruvate Dehydrogenase ◽  
Oxidative Metabolism ◽  
Aspartate Aminotransferase ◽  
Aerobic Training ◽  
Exercise Intervention ◽  
Complex Iii ◽  
Men And Women ◽  
The Metabolic Syndrome

Aerobic conditioned muscle shows increased oxidative metabolism or glucose relative to untrained muscle at a given absolute exercise intensity. The studies of a targeted risk reduction intervention through defined exercise (STRRIDE) study is an aerobic exercise intervention in men and women with features of metabolic syndrome (Kraus WE, Torgan CE, Duscha BD, Norris J, Brown SA, Cobb FR, Bales CW, Annex BH, Samsa GP, Houmard JA, and Slentz CA, Med Sci Sports Exerc 33: 1774–1784, 2001), with four muscle biopsies taken during training and detraining time points. Here, we expanded a previous study (Hittel DS, Kraus WE, and Hoffman EP, J Physiol 548: 401–410, 2003) and used mRNA profiling to investigate gene transcripts associated with energy and substrate metabolism in STRRIDE participants. We found coordinate regulation of key metabolic enzymes with aerobic training in metabolic syndrome (aspartate aminotransferase 1, lactate dehydrogenase B, and pyruvate dehydrogenase-α1). All were also quickly downregulated by detraining, although the induction was not an acute response to activity. Protein and enzymatic assays were used to validate mRNA induction with aerobic training and loss with detraining (96 h to 2 wk) in 10 male and 10 female STRRIDE subjects. We propose that training coordinately increases the levels of aspartate aminotransferase 1, lactate dehydrogenase B, and pyruvate dehydrogenase-α1 subunit, increasing glucose metabolism in muscle by liberating pyruvate for oxidative metabolism and, therefore, limiting lactate efflux. Serial measurement of fasting plasma lactate from 62 subjects from the same exercise group demonstrated a significant decrease of circulating lactate with training. We also found evidence for sex-specific molecular remodeling of muscle with ubiquinol-cytochrome c reductase core protein II, a component of mitochondrial respiratory complex III, which showed an increase after training that was specific to women. These biochemical adaptations complement existing molecular models for improved glucose tolerance with exercise intervention in prediabetic individuals.

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