Aging is associated with decreases in aerobic capacity, cardiac function, and insulin sensitivity as well as alterations in myocardial substrate metabolism. Endurance exercise training (EET) improves cardiac function in a gender-specific manner, and EET has been shown to improve whole body glucose tolerance, but its effects on myocardial metabolism are unclear. Accordingly, we studied the effect of EET on myocardial substrate metabolism in older men and women. Twelve healthy older individuals (age: 60–75 yr; 6 men and 6 women) underwent PET with [15O]water, [11C]acetate, [11C]glucose, and [11C]palmitate for the assessment of myocardial blood flow (MBF), myocardial O2 consumption (MV̇o2), myocardial glucose utilization (MGU), and myocardial fatty acid utilization (MFAU), respectively, at rest and during dobutamine infusion (10 μg·kg−1·min−1). Measurements were repeated after 11 mo of EET. Maximal O2 uptake (V̇o2max) increased ( P = 0.005) after EET. MBF was unaffected by training, as was resting MV̇o2; however, posttraining dobutamine MV̇o2 was significantly higher ( P = 0.05), as was MGU ( P < 0.04). Although overall dobutamine MFAU was unchanged, posttraining dobutamine MFAU increased in women ( P = 0.01) but decreased in men ( P = 0.03). Thus, EET in older individuals improves the catecholamine response of myocardial glucose metabolism. Moreover, gender differences exist in the myocardial fatty acid metabolic response to training. These findings suggest a role for altered myocardial substrate metabolism in modulating the cardiovascular benefits of EET in older individuals.
P2095SIRT4 regulates fatty acid utilisation and cardiac function in the normal and diabetic heart
