scholarly journals Increased energy metabolism rescues glia-induced pathology in a Drosophila model of Huntington's disease

2010 ◽  
Vol 19 (17) ◽  
pp. 3372-3382 ◽  
Author(s):  
Marie-Thérèse Besson ◽  
Pascale Dupont ◽  
Yih-Woei C. Fridell ◽  
Jean-Charles Liévens
Keyword(s):  
Energy Metabolism ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Drosophila Model

Methylene Blue Partially Rescues Heart Defects in a Drosophila Model of Huntington’s Disease

2015 ◽  
Vol 4 (2) ◽  
pp. 173-186 ◽  
Author(s):  
Raheleh Heidari ◽  
Véronique Monnier ◽  
Elodie Martin ◽  
Hervé Tricoire
Keyword(s):  
Methylene Blue ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Heart Defects ◽  
Drosophila Model

NMR Spectroscopy-based Metabolomics of Drosophila Model of Huntington’s Disease Suggests Altered Cell Energetics

2017 ◽  
Vol 16 (10) ◽  
pp. 3863-3872 ◽  
Author(s):  
Virender Singh ◽  
Raj Kumar Sharma ◽  
Thamarailingam Athilingam ◽  
Pradip Sinha ◽  
Neeraj Sinha ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Drosophila Model ◽  
Altered Cell

scholarly journals Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models

2021 ◽  
Vol 14 (10) ◽  
pp. 1044
Author(s):  
Letizia Pruccoli ◽  
Carlo Breda ◽  
Gabriella Teti ◽  
Mirella Falconi ◽  
Flaviano Giorgini ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuronal Death ◽  
Trinucleotide Repeat ◽  
Neurodegenerative Disorder ◽  
Positive Impact ◽  
Neuroprotective Effects ◽  
Drosophila Model ◽  
Exon 1 ◽  
Transgenic Drosophila

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene. This mutation leads to the production of mutant HTT (mHTT) protein which triggers neuronal death through several mechanisms. Here, we investigated the neuroprotective effects of esculetin (ESC), a bioactive phenolic compound, in an inducible PC12 model and a transgenic Drosophila melanogaster model of HD, both of which express mHTT fragments. ESC partially inhibited the progression of mHTT aggregation and reduced neuronal death through its ability to counteract the oxidative stress and mitochondria impairment elicited by mHTT in the PC12 model. The ability of ESC to counteract neuronal death was also confirmed in the transgenic Drosophila model. Although ESC did not modify the lifespan of the transgenic Drosophila, it still seemed to have a positive impact on the HD phenotype of this model. Based on our findings, ESC may be further studied as a potential neuroprotective agent in a rodent transgenic model of HD.

Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease

2006 ◽  
Vol 48 (2) ◽  
pp. 93-99 ◽  
Author(s):  
Svatava Kašparová ◽  
Zuzana Sumbalová ◽  
Peter Bystrický ◽  
Jarmila Kucharská ◽  
Tibor Liptaj ◽  
...  
Keyword(s):  
Animal Model ◽  
Vitamin E ◽  
Energy Metabolism ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Coenzyme Q10 ◽  
Brain Energy Metabolism ◽  
Brain Energy

scholarly journals Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

2014 ◽  
Vol 51 (1) ◽  
pp. 331-348 ◽  
Author(s):  
Luana Naia ◽  
I. Luísa Ferreira ◽  
Teresa Cunha-Oliveira ◽  
Ana I. Duarte ◽  
Márcio Ribeiro ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Huntington's Disease ◽  
Signaling Pathways ◽  
Huntington’S Disease ◽  
Mitochondrial Function ◽  
Insulin Signaling

Deficits in Striatal Dopamine D2 Receptors and Energy Metabolism Detected by in Vivo MicroPET Imaging in a Rat Model of Huntington's Disease

2000 ◽  
Vol 166 (2) ◽  
pp. 287-297 ◽  
Author(s):  
Dalia M. Araujo ◽  
Simon R. Cherry ◽  
Keith J. Tatsukawa ◽  
Tatsushi Toyokuni ◽  
Harley I. Kornblum
Keyword(s):  
Energy Metabolism ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Rat Model ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Micropet Imaging ◽  
Dopamine D2

scholarly journals A study of molecular changes relating to energy metabolism and cellular stress in people with Huntington’s disease: looking for biomarkers

2012 ◽  
Vol 45 (1-2) ◽  
pp. 71-85 ◽  
Author(s):  
Jolanta Krzysztoń-Russjan ◽  
Daniel Zielonka ◽  
Joanna Jackiewicz ◽  
Sylwia Kuśmirek ◽  
Irena Bubko ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cellular Stress ◽  
Molecular Changes
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