scholarly journals Does lobar or size-reduced lung transplantation offer satisfactory early and late outcomes?

2020 ◽  
Vol 31 (1) ◽  
pp. 93-97
Author(s):  
João Santos Silva ◽  
Anne Olland ◽  
Gilbert Massard ◽  
Pierre-Emmanuel Falcoz
Keyword(s):  
Intensive Care Unit ◽  
Lung Transplantation ◽  
Therapeutic Option ◽  
Survival Rates ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Medium Term ◽  
Size Mismatch ◽  
Study Type

Summary A best evidence topic was constructed according to a structured protocol. The question addressed was whether size-reduced or lobar lung transplantation (LLTx) offers the same benefit as classic lung transplantation (LTx). Of the 147 papers found using the reported search, 9 were selected to provide the best evidence. Details of the studies regarding authors, date, journal, country of publication, study type, group studied, relevant outcomes and results are given. All studies reported survival rates of LLTx and most compared it with classical LTx. No statistical differences were reported in medium term and long term. Two of the studies reported a higher incidence of postoperative complications, such as the need for cardiopulmonary bypass, reperfusion oedema or primary graft dysfunction, and longer intubation or intensive care unit stay times. Although the largest study showed a significantly worse 1-year survival in LLTx, a sub-analysis considering patients successfully discharged showed similar outcomes at 1, 3 and 5 years when compared with classic LTx patients. We conclude that LLTx is a valid therapeutic option for recipients with significant donor size mismatch, offering similar outcomes as classical LTx in the medium term and long term.

Primary Graft Dysfunction and Long-term Pulmonary Function After Lung Transplantation

2007 ◽  
Vol 26 (10) ◽  
pp. 1004-1011 ◽  
Author(s):  
Bryan A. Whitson ◽  
Matthew E. Prekker ◽  
Cynthia S. Herrington ◽  
Timothy P.M. Whelan ◽  
David M. Radosevich ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction

Extracorporeal membrane oxygenation for grade 3 primary graft dysfunction after lung transplantation: Long‐term outcomes

2019 ◽  
Vol 33 (3) ◽  
pp. e13480 ◽  
Author(s):  
Jocelyn Bellier ◽  
Pierre Lhommet ◽  
Pierre Bonnette ◽  
Philippe Puyo ◽  
Morgan Le Guen ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Long Term Outcomes ◽  
Membrane Oxygenation ◽  
Grade 3

Extracorporeal Membrane Oxygenation for Primary Graft Dysfunction After Lung Transplantation: Long-Term Survival

2009 ◽  
Vol 87 (3) ◽  
pp. 854-860 ◽  
Author(s):  
Christian A. Bermudez ◽  
Prasad S. Adusumilli ◽  
Kenneth R. McCurry ◽  
Diana Zaldonis ◽  
Maria M. Crespo ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Term Survival ◽  
Long Term Survival ◽  
Membrane Oxygenation

scholarly journals Lung transplantation for acute exacerbation of interstitial lung disease

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2020-215681
Author(s):  
Mwelwa Chizinga ◽  
Tiago N Machuca ◽  
Abbas Shahmohammadi ◽  
Divya C Patel ◽  
Ayoub Innabi ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Stable Disease ◽  
Therapeutic Option ◽  
Group Versus ◽  
Hospital Length ◽  
Interstitial Lung Diseases ◽  
Hospital Length Of Stay ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Post Transplant

BackgroundAcute exacerbations of interstitial lung diseases (AE-ILD) have a high mortality rate with no effective medical therapies. Lung transplantation is a potentially life-saving option for patients with AE-ILD, but its role is not well established. The aim of this study is to determine if this therapy during AE-ILD significantly affects post-transplant outcomes in comparison to those transplanted with stable disease.MethodsWe conducted a retrospective study of consecutive patients with AE-ILD admitted to our institution from 2015 to 2018. The comparison group included patients with stable ILD listed for lung transplant during the same period. The primary end-points were in-hospital mortality for patients admitted with AE-ILD and 1-year survival for the transplanted patients.ResultsOf 53 patients admitted for AE-ILD, 28 were treated with medical therapy alone and 25 underwent transplantation. All patients with AE-ILD who underwent transplantation survived to hospital discharge, whereas only 43% of the AE-ILD medically treated did. During the same period, 67 patients with stable ILD underwent transplantation. Survival at 1 year for the transplanted patients was not different for the AE-ILD group versus stable ILD group (96% vs 92.5%). The rates of primary graft dysfunction, post-transplant hospital length-of-stay and acute cellular rejection were similar between the groups.ConclusionPatients with ILD transplanted during AE-ILD had no meaningful difference in overall survival, rate of primary graft dysfunction or acute rejection compared with those transplanted with stable disease. Our results suggest that lung transplantation can be considered as a therapeutic option for selected patients with AE-ILD.

scholarly journals Lung size mismatch and primary graft dysfunction after bilateral lung transplantation

2015 ◽  
Vol 34 (2) ◽  
pp. 233-240 ◽  
Author(s):  
Michael Eberlein ◽  
Robert M. Reed ◽  
Servet Bolukbas ◽  
Joshua M. Diamond ◽  
Keith M. Wille ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Size Mismatch ◽  
Bilateral Lung Transplantation ◽  
Bilateral Lung

Primary graft dysfunction after lung transplantation: Medium and long term outcomes

2015 ◽  
Author(s):  
Valeria Rossetti ◽  
Letizia Corinna Morlacchi ◽  
Maria Pappalettera ◽  
Paolo Tarsia ◽  
Alessandro Palleschi ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Long Term Outcomes

In lung transplantation, are pulmonary grafts from donors deceased from hanging as suitable as grafts from donors deceased from other causes?

2019 ◽  
Vol 30 (1) ◽  
pp. 30-32
Author(s):  
João Santos Silva ◽  
Anne Olland ◽  
Gilbert Massard ◽  
Pierre-Emmanuel Falcoz
Keyword(s):  
Lung Transplantation ◽  
Observational Studies ◽  
Ex Vivo ◽  
Lung Perfusion ◽  
Graft Dysfunction ◽  
Post Transplantation ◽  
Donor Pool ◽  
Ex Vivo Lung Perfusion ◽  
Study Type

Abstract A best evidence topic was constructed according to a structured protocol. The question addressed was whether pulmonary grafts from donors deceased from hanging offer the same benefit as grafts from donors deceased from other causes in lung transplantation. Of the 17 papers found, 4 provided the best evidence to answer the question. The authors, date, journal, country of publication, study type, group studied, relevant outcomes and results of these papers are tabulated. One study reported a large cohort of donors and analysed the outcomes by cause of death, reporting no differences in survival. The remaining 3 papers analysed observational studies on the outcomes of lung transplantation using pulmonary grafts from donors deceased from hanging, compared with donors deceased from other causes. No differences in the rates of post-transplantation pulmonary graft dysfunction and long-term overall survival were reported. Although the cohort of donors deceased from hanging is small, we conclude that these donors are an important contribution to the donor pool. Ex vivo lung perfusion may have a role in assessing graft viability in this scenario.

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