scholarly journals Association Between Maternal Human Papillomavirus Infection and Adverse Pregnancy Outcomes: Systematic Review and Meta-Analysis

2020 ◽  
Vol 221 (12) ◽  
pp. 1925-1937 ◽  
Author(s):  
Joseph Niyibizi ◽  
Nadège Zanré ◽  
Marie-Hélène Mayrand ◽  
Helen Trottier
Keyword(s):  
Human Papillomavirus ◽  
Pregnancy Outcomes ◽  
Intrauterine Growth Restriction ◽  
Meta Analysis ◽  
Adverse Pregnancy Outcomes ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Intrauterine Growth ◽  
Preterm Premature Rupture ◽  
Adverse Pregnancy

Abstract Background Experimental studies provide evidence of the harmful effect of human papillomavirus (HPV) infection on pregnancy, but observational studies are inconclusive. We systematically assessed the association between HPV and adverse pregnancy outcomes. Methods We searched electronic databases up to December 1, 2019. We included observational studies on the association between HPV and adverse pregnancy outcomes. We conducted a random-effect meta-analysis for each outcome and assessed heterogeneity between studies. Results From 3034 citations, we included 38 studies and quantitatively synthesized 36 studies. Human papillomavirus was significantly associated with preterm birth (age-adjusted odds ratio [aOR], 1.50; 95% confidence interval [CI], 1.19–1.88), preterm premature rupture of membranes (aOR, 1.96; 95% CI, 1.11–3.45), premature rupture of membranes (aOR, 1.42; 95% CI, 1.08–1.86), intrauterine growth restriction (aOR, 1.17; 95% CI, 1.01–1.37), low birth weight (aOR, 1.91; 95% CI, 1.33–2.76), and fetal death (aOR, 2.23; 95% CI, 1.14–4.37). No significant association was found for spontaneous abortion (aOR, 1.14; 95% CI, 0.40–3.22) and pregnancy-induced hypertensive disorders (aOR, 1.24; 95% CI, 0.80–1.92). Most of the studies were of moderate or low quality, and substantial between-studies heterogeneity remained unexplained. Conclusions We found a consistent and significant association between HPV and preterm birth and preterm premature rupture of membranes. Human papillomavirus may also be associated with intrauterine growth restriction, low birth weight, and fetal death, but findings are limited by suboptimal control of biases.

scholarly journals Pregnancy Outcome in Uterine Anomalies

2017 ◽  
Vol 3 (1) ◽  
pp. 31-33
Author(s):  
Nagendra Prasad ◽  
James Thingujam
Keyword(s):  
Retrospective Study ◽  
Pregnancy Outcome ◽  
Pregnancy Outcomes ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Premature Rupture ◽  
Intrauterine Growth ◽  
Preterm Premature Rupture ◽  
Uterine Anomalies ◽  
Uterine Anomaly

ABSTRACT Maternal with congenitial anomalies are known to have higher incidence of infertility, intrauterine growth restriction, fetal malposition, preterm labor, preterm premature rupture of membrane and increased cesaerean section rate. Study Design This is retrospective study, the pregnancies with uterine anomaly confirmed by ultrasound between Jan 2016 to jan 2017 at our hospital was taken and its outcome is observed. Reults The majority of preterm delivery in our study are mainly associated with septate and bicornuate uterus. Cesaerean section comprised of 80% and its major indication is due to fetal malpresentation (breech). Thus Pregnancy outcomes of individual depending on the type of uterine anomalies. How to cite this article Nagarathnamma R, James T, Prasad N. Pregnancy Outcome in Uterine Anomalies. J Med Sci 2017;3(1):31-33.

Intrauterine Growth Restriction, Low Birth Weight, and Preterm Birth: Adverse Pregnancy Outcomes and Their Association With Maternal Periodontitis

2007 ◽  
Vol 78 (12) ◽  
pp. 2266-2276 ◽  
Author(s):  
Fernanda Mafra Siqueira ◽  
Luís Otávio Miranda Cota ◽  
José Eustáquio Costa ◽  
João Paulo Amaral Haddad ◽  
Ângela Maria Quintão Lana ◽  
...  
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Pregnancy Outcomes ◽  
Intrauterine Growth Restriction ◽  
Adverse Pregnancy Outcomes ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Adverse Pregnancy

scholarly journals Intersections between Adverse Pregnancy Outcomes

2005 ◽  
Vol 1 (2) ◽  
pp. 245-251
Author(s):  
Roberta B Ness
Keyword(s):  
Pregnancy Outcomes ◽  
Intrauterine Growth Restriction ◽  
Reproductive Failure ◽  
Adverse Pregnancy Outcomes ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Adverse Impacts ◽  
Adverse Pregnancy

Reproductive failure in a variety of forms, whether it be infertility, miscarriage, pre-eclampsia, prematurity or intrauterine growth restriction, may aggregate within individuals. This observation, although rarely studied, suggests that single pathophysiologies may be associated with a variety of reproductive morbidities. In this review, hyperimmune responsiveness to pregnancy is provided as one example of a process leading to a multitude of adverse impacts on healthy childbearing. Further research on reproductive failure as a spectrum is warranted.

Increased levels of serum clusterin is associated with intrauterine growth restriction and adverse pregnancy outcomes in preeclampsia

2016 ◽  
Vol 44 (3) ◽  
Author(s):  
Efser Oztas ◽  
Sibel Ozler ◽  
Ali Ozgur Ersoy ◽  
Can Tekin Iskender ◽  
Ayhan Sucak ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Intrauterine Growth Restriction ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Outcomes ◽  
Growth Restriction ◽  
Enzyme Linked Immunosorbent Assay ◽  
Multivariable Logistic Regression Analysis ◽  
Maternal Outcomes ◽  
Intrauterine Growth ◽  
Adverse Pregnancy

AbstractOur aim was to investigate serum clusterin levels in preeclampsia and to determine whether any changes in clusterin levels are useful in distinguishing the presence of concomitant intrauterine growth restriction (IUGR) and in predicting adverse pregnancy outcomes.A prospective case-control study was carried out which included 86 pregnant women (47 patients with preeclampsia and 39 healthy controls). Maternal serum samples obtained from all participants and clusterin levels were determined by enzyme-linked immunosorbent assay (ELISA).Compared with controls, women with preeclampsia had significantly higher clusterin levels (mean 83.8±23.6 vs. 119.2±40.5, P<0.01). Further analysis revealed the highest clusterin levels were in patients with preeclampsia and IUGR (P<0.001). According to the receiver operating characteristic (ROC) analysis performed for the predictive value of clusterin levels for adverse maternal outcomes, the area under the curve (AUC) was 0.738 (95% CI: 0.616–0.859). The best clusterin cut-off value in predicting adverse maternal outcomes was 102.6 pg/mL with 75% sensitivity and 66% specifity. Multivariable logistic regression analysis revealed serum clusterin levels of >102.6 pg/mL was independently associated with preeclampsia (OR: 6.18, 95% CI: 2.41–15.9) and maternal adverse outcomes (OR: 5.13, 95% CI: 2.01–13.1) and also clusterin levels higher than 117.4 pg/mL were associated with adverse neonatal outcomes (OR: 5.02, 95% CI: 1.04–24.3).The current study suggests that increased levels of clusterin is associated with IUGR and probably predictive for adverse pregnancy outcomes in preeclampsia.

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