scholarly journals Comparative immunogenicity of enhanced seasonal influenza vaccines in older adults: a systematic review and meta-analysis

2018 ◽  
Author(s):  
Tiffany W Y Ng ◽  
Benjamin J Cowling ◽  
Hui Zhi Gao ◽  
Mark G Thompson
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Seasonal Influenza ◽  
Meta Analysis ◽  
Influenza Vaccines

Relative Effectiveness of Cell-Cultured versus Egg-Based Seasonal Influenza Vaccines in Preventing Influenza-Related Outcomes in Subjects 18 Years Old or Older: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Joan Puig-Barberà ◽  
Sonia Tamames-Gómez ◽  
Pedro Plans-Rubio ◽  
José María Eirós-Bouza
Keyword(s):  
Systematic Review ◽  
Seasonal Influenza ◽  
Influenza Season ◽  
Meta Analysis ◽  
Relative Effectiveness ◽  
Risk Of Bias ◽  
Influenza Vaccines ◽  
Sensitivity Analyses ◽  
Exclusion Criteria ◽  
Seed Cell

Avian mutations in vaccine strains obtained from embryonated eggs could impair vaccine effec-tiveness. We performed a systematic review and meta-analysis of the adjusted relative vaccine effectiveness (arVE) of seed cell-cultured influenza vaccines (ccIV) compared to egg-based influ-enza vaccines (eIV) in preventing laboratory-confirmed influenza related outcomes (IRO) or IRO by clinical codes, in subjects 18 and over. We completed the literature search in January 2021; ap-plied exclusion criteria, evaluated risk of bias of the evidence, and performed heterogeneity, pub-lication bias, qualitative, quantitative and sensitivity analyses. All estimates were computed us-ing a random approach. International Prospective Register of Systematic Reviews, CRD42021228290. We identified 12 publications that reported 26 adjusted arVE results. Five publications reported 13 laboratory confirmed arVE and seven reported 13 code-ascertained arVE. Nine publications with 22 results were at low risk of bias. Heterogeneity was explained by season and risk of bias. We found a significant 11% (8 to 14%) adjusted arVE favoring ccIV in preventing any IRO in the 2017-2018 influenza season. The arVE was 3% (-01 to 7%) in the 2018-2019 influenza season. We found moderate evidence of a significant advantage of the ccIV in preventing IRO, compared to eIV, in a well-matched A(H3N2) predominant season.

scholarly journals Effectiveness of seasonal influenza vaccines in children – a systematic review and meta-analysis

2013 ◽  
Vol 54 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Ivana Lukšić ◽  
Sarah Clay ◽  
Rachel Falconer ◽  
Dražen Pulanić ◽  
Igor Rudan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Seasonal Influenza ◽  
Meta Analysis ◽  
Influenza Vaccines

Priming with MF59 adjuvanted versus nonadjuvanted seasonal influenza vaccines in children – A systematic review and a meta-analysis

Vaccine ◽  
2020 ◽  
Vol 38 (3) ◽  
pp. 608-619 ◽  
Author(s):  
Manish M. Patel ◽  
William Davis ◽  
Lauren Beacham ◽  
Sarah Spencer ◽  
Angela P. Campbell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Seasonal Influenza ◽  
Meta Analysis ◽  
Influenza Vaccines

scholarly journals Relative Effectiveness of Cell-Cultured versus Egg-Based Seasonal Influenza Vaccines in Preventing Influenza-Related Outcomes in Subjects 18 Years Old or Older: A Systematic Review and Meta-Analysis

2022 ◽  
Vol 19 (2) ◽  
pp. 818
Author(s):  
Joan Puig-Barberà ◽  
Sonia Tamames-Gómez ◽  
Pedro Plans-Rubio ◽  
José María Eiros-Bouza
Keyword(s):  
Systematic Review ◽  
Seasonal Influenza ◽  
Influenza Season ◽  
Meta Analysis ◽  
Relative Effectiveness ◽  
Vaccine Effectiveness ◽  
Risk Of Bias ◽  
Influenza Vaccines ◽  
Sensitivity Analyses ◽  
Exclusion Criteria

Avian mutations in vaccine strains obtained from embryonated eggs could impair vaccine effectiveness. We performed a systematic review and meta-analysis of the adjusted relative vaccine effectiveness (arVE) of seed cell-cultured influenza vaccines (ccIV) compared to egg-based influenza vaccines (eIV) in preventing laboratory-confirmed influenza related outcomes (IRO) or IRO by clinical codes, in subjects 18 and over. We completed the literature search in January 2021; applied exclusion criteria, evaluated risk of bias of the evidence, and performed heterogeneity, publication bias, qualitative, quantitative and sensitivity analyses. All estimates were computed using a random approach. International Prospective Register of Systematic Reviews, CRD42021228290. We identified 12 publications that reported 26 adjusted arVE results. Five publications reported 13 laboratory confirmed arVE and seven reported 13 code-ascertained arVE. Nine publications with 22 results were at low risk of bias. Heterogeneity was explained by season. We found a significant 11% (8 to 14%) adjusted arVE favoring ccIV in preventing any IRO in the 2017–2018 influenza season. The arVE was 3% (−2% to 7%) in the 2018–2019 influenza season. We found moderate evidence of a significant advantage of the ccIV in preventing IRO, compared to eIV, in a well-matched A(H3N2) predominant season.

scholarly journals Relative Effectiveness of Cell-Cultured versus Egg-Based Seasonal Influenza Vaccines in Preventing Influenza-Related Outcomes in Subjects 18 Years Old or Older: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Joan Puig-Barberà ◽  
Sonia Tamames-Gómez ◽  
Pedro Plans-Rubio ◽  
José María Eirós-Bouza
Keyword(s):  
Systematic Review ◽  
Seasonal Influenza ◽  
Influenza Season ◽  
Meta Analysis ◽  
Relative Effectiveness ◽  
Risk Of Bias ◽  
Influenza Vaccines ◽  
Sensitivity Analyses ◽  
Exclusion Criteria ◽  
Seed Cell

Avian mutations in vaccine strains obtained from embryonated eggs could impair vaccine effec-tiveness. We performed a systematic review and meta-analysis of the adjusted relative vaccine effectiveness (arVE) of seed cell-cultured influenza vaccines (ccIV) compared to egg-based influ-enza vaccines (eIV) in preventing laboratory-confirmed influenza related outcomes (IRO) or IRO by clinical codes, in subjects 18 and over. We completed the literature search in January 2021; ap-plied exclusion criteria, evaluated risk of bias of the evidence, and performed heterogeneity, pub-lication bias, qualitative, quantitative and sensitivity analyses. All estimates were computed us-ing a random approach. International Prospective Register of Systematic Reviews, CRD42021228290. We identified 12 publications that reported 26 adjusted arVE results. Five publications reported 13 laboratory confirmed arVE and seven reported 13 code-ascertained arVE. Nine publications with 22 results were at low risk of bias. Heterogeneity was explained by season and risk of bias. We found a significant 11% (8 to 14%) adjusted arVE favoring ccIV in preventing any IRO in the 2017-2018 influenza season. The arVE was 3% (-01 to 7%) in the 2018-2019 influenza season. We found moderate evidence of a significant advantage of the ccIV in preventing IRO, compared to eIV, in a well-matched A(H3N2) predominant season.

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