The relationship between exposure to PM2.5 and atrial fibrillation in older adults: A systematic review and meta-analysis

Background: Chronic kidney disease (CKD) strongly predicts sudden cardiac death and may elevate the risk of certain cardiac arrhythmias like atrial fibrillation; however, the relationships between CKD and various types of arrhythmia are not well-characterized. Methods: We performed a systematic review and meta-analysis by searching Embase and PubMed for prospective, cross-sectional, and case-control studies examining the associations of two key CKD measures, estimated glomerular filtration rate (eGFR) and albuminuria, with arrhythmias in adults that were published until July 2018. We performed qualitative assessment of studies using the Newcastle Ottawa Quality Assessment Scale. We pooled the results using random-effects models. Results: Among 16,245 articles, we identified 34 prospective (n=24,213,233), 21 cross-sectional (n=253,328), and 4 case-control (n=1,694) studies that included diverse study populations from 19 countries and were mostly high quality. Most prospective studies examined the relationship between eGFR and atrial fibrillation (AF), and demonstrated that lower eGFR was associated with a higher risk of AF (pooled hazard ratio [HR] 1.72 [95% CI: 1.30, 2.27] comparing reduced vs. referent eGFR groups)[ Figure ]. A few studies examined albuminuria and demonstrated its associations with AF (pooled HR 2.16 [95% CI: 1.74, 2.67] comparing high vs. low albuminuria). Results were similar for cross-sectional studies. Four prospective studies reported a higher incidence of ventricular tachycardia resulting in ICD shock according to reduced eGFR (pooled HR 2.32 [95% CI: 1.74, 3.09] comparing reduced vs. referent eGFR groups). Limited number of studies examined other types of arrhythmia. Conclusion: We identified robust data on the relationship between CKD (eGFR and albuminuria) and AF. Reduced eGFR was associated with life-threatening ventricular arrhythmias. Our review highlights the need of future studies for non-AF arrhythmias, especially in the context of albuminuria.

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Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis

Cardiology Research and Practice ◽

10.1155/2019/8985273 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Ming Yuan ◽

Zhiwei Zhang ◽

Gary Tse ◽

Xiaojin Feng ◽

Panagiotis Korantzopoulos ◽

...

Keyword(s):

Atrial Fibrillation ◽

Systematic Review ◽

Cancer Diagnosis ◽

Meta Analysis ◽

Solid Cancer ◽

Hazard Ratios ◽

Increased Risk ◽

The Relationship ◽

Onset Atrial Fibrillation ◽

Embolic Risk

Aims. Previous studies have demonstrated epidemiological evidence for an association between cancer and the development of new-onset atrial fibrillation (AF). However, these results have been conflicting. This systematic review and meta-analysis was conducted to examine the relationship between cancer and the risk of developing atrial fibrillation. Methods. PubMed and Web of Science were searched for publications examining the association between cancer and atrial fibrillation risk published until June 2017. Adjusted odds ratios (ORs) or hazard ratios (HRs) and 95% CI were extracted and pooled. Results. A total of five studies involving 5,889,234 subjects were included in this meta-analysis. Solid cancer patients are at higher risk developing atrial fibrillation compared to noncancer patients (OR 1.47, 95% CI 1.31 to 1.66, p<0.00001; I2 = 67%, p=0.02). The risk of atrial fibrillation was highest within 90 days of cancer diagnosis (OR 7.62, 95% CI 3.08 to 18.88, p<0.00001) and this risk diminished with time. Conclusions. The risk of AF was highest within 90 days of cancer diagnosis. We should take into account the increased risk of atrial fibrillation development and, after this, study the embolic risk and potential indication of oral anticoagulation.

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The Relationship Between Depression and Frailty in Community‐Dwelling Older People: A Systematic Review and Meta‐Analysis of 84,351 Older Adults

Journal of Nursing Scholarship ◽

10.1111/jnu.12501 ◽

2019 ◽

Vol 51 (5) ◽

pp. 547-559 ◽

Cited By ~ 11

Author(s):

Wen Chu ◽

Shu‐Fang Chang ◽

Hsu‐Yu Ho ◽

Hsiang‐Chun Lin

Keyword(s):

Systematic Review ◽

Older Adults ◽

Older People ◽

Meta Analysis ◽

Community Dwelling ◽

Community Dwelling Older People ◽

The Relationship

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The relationship between exposure to PM2.5 and heart rate variability in older adults: A systematic review and meta-analysis

Chemosphere ◽

10.1016/j.chemosphere.2020.127635 ◽

2020 ◽

Vol 261 ◽

pp. 127635

Author(s):

Fenghong Wang ◽

Qingqing Liang ◽

Mengqi Sun ◽

Yuexiao Ma ◽

Lisen Lin ◽

...

Keyword(s):

Systematic Review ◽

Older Adults ◽

Heart Rate ◽

Heart Rate Variability ◽

Meta Analysis ◽

The Relationship

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The relationship between preoperative serum vitamin D deficiency and postoperative atrial fibrillation: A systematic review and meta-analysis

Journal of Cardiovascular and Thoracic Research ◽

10.34172/jcvtr.2021.25 ◽

2021 ◽

Vol 13 (2) ◽

pp. 102-108

Author(s):

Mehran Rahimi ◽

Mohammadreza Taban-Sadeghi ◽

Leila Nikniaz ◽

Fariba Pashazadeh

Keyword(s):

Atrial Fibrillation ◽

Systematic Review ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Serum Vitamin ◽

Postoperative Atrial Fibrillation ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Relationship

Postoperative atrial fibrillation (POAF) is the most common arrhythmia seen in the first days following cardiac surgeries. Recently, there is a growing discussion regarding the link between vitamin D deficiency and POAF development. This systematic review and meta-analysis of the observational studies aimed at evaluating the association between preoperative vitamin D deficiency and Postoperative atrial fibrillation. In this study, using PubMed, Scopus, Google Scholar, EMBASE, Web of Science, and Cochrane Libraries, we searched for records published before July 2020. Two reviewers screened for studies that examined the relationship between preoperative vitamin D levels and the generation of POAF. Data regarding study design, patient characteristics, definition of atrial fibrillation (AF) , type of surgery, vitamin D levels, and measurement methods were extracted. Five studies were included in the meta-analysis. Our primary analysis showed a significant relationship between preoperative levels of vitamin D and POAF development (mean differences (MD) = -2.851, 95% confidence interval (CI) =-5.506 to -0.195; P value 0.035). Our meta-analysis suggested serum vitamin D deficiency is associated with an increased risk of POAF development. Further large scale interventional studies are needed to explore whether vitamin D supplementation will prevent POAF.

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Is Epicardial Adipose Tissue Associated with Atrial Fibrillation Following Cardiac Surgery? A Systematic Review and Meta-Analysis

The Heart Surgery Forum ◽

10.1532/hsf.3975 ◽

2021 ◽

Vol 24 (5) ◽

pp. E801-E807

Author(s):

Rina Sha ◽

Wenqiang Han ◽

Mingjie Lin ◽

Jingquan Zhong

Keyword(s):

Atrial Fibrillation ◽

Systematic Review ◽

Adipose Tissue ◽

Cardiac Surgery ◽

Epicardial Adipose Tissue ◽

Meta Analysis ◽

Random Effects Model ◽

Meta Analyses ◽

The Relationship ◽

Af Recurrence

Background: Although epicardial adipose tissue (EAT) has been proven to be related to atrial fibrillation (AF) and post-ablation AF recurrence, the association between EAT and AF after cardiac surgery (AFACS) remains unclear. Objective: This study was a systematic review and meta-analysis that assessed the relationship between EAT and AFACS. Methods: Electronic databases were systematically searched for “atrial fibrillation” and “epicardial adipose tissue.” The analysis was stratified according to the EAT measurement into three meta-analyses as (1) total EAT volume, (2) left atrial (LA)-EAT volume, and (3) EAT thickness. Standardized mean difference (SMD) was estimated using a random effects model. Results: Eight articles with 10 studies (546 patients) were included. The meta-analysis revealed that EAT was higher in those with AFACS irrespective of the EAT measurement (total EAT volume: SMD = 0.56 mL, 95% confidence interval, CI = 0.56–1.10 mL, I2 = 0.90, P = .04; EAT thickness: SMD = 0.85 mm, 95% CI = 0.04–1.65 mm, I2 = 0.90, P = .04; LA-EAT volume: SMD = 0.57 mL, 95% CI = 0.23–0.92 mL, I2 = 0.00, P = .001). Conclusion: EAT was higher in patients with AFACS, measured either as volume or thickness.

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Falls in older adults with major depressive disorder (MDD): a systematic review and exploratory meta-analysis of prospective studies

International Psychogeriatrics ◽

10.1017/s104161021500126x ◽

2015 ◽

Vol 28 (1) ◽

pp. 23-29 ◽

Cited By ~ 22

Author(s):

Brendon Stubbs ◽

Jean Stubbs ◽

Solomon Donald Gnanaraj ◽

Andrew Soundy

Keyword(s):

Systematic Review ◽

Older Adults ◽

Major Depressive Disorder ◽

Methodological Quality ◽

Meta Analysis ◽

Major Depressive ◽

Depressive Symptomology ◽

Falls In Older Adults ◽

The Relationship

ABSTRACTBackground:Depressive symptomology is now widely recognized as a key risk factor for falls. The evidence regarding the impact of major depressive disorder (MDD) on falls is unclear. A systematic review and exploratory meta-analysis was undertaken to explore the relationship between MDD and falls.Methods:Major electronic database were searched from inception till April 2015. Studies that defined MDD and measured falls prospectively in older adults (≥60 years) were included. Studies relying on depressive symptomology alone were excluded. The methodological quality of included articles was assessed and study findings were synthesized using an exploratory meta-analysis.Results:From a potential of 415 articles, only three studies met the inclusion criteria. This included 976 unique older adults with a range of mean age from ≥65 to 83 years. The methodological quality of included studies was satisfactory. None of the included studies’ primary aim was to investigate the relationship between MDD and falls. The exploratory meta-analysis demonstrated older adults with MDD are at increased risk of falling compared to non-depressed older adults (odds ratio (OR) 4.0, 95% CI 2.0–8.1, I2 = 60%, n = 976).Conclusion:There is a paucity of research considering falls in older adults with MDD. Our results demonstrate that the odds of falling appear to be greater among people with MDD (OR 4.0) than in previous meta-analyses that have only considered subthreshold depressive symptoms. Given the distinct nature and challenges with MDD, more research is required to better understand the falls risk in this group.

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