Surface immunoglobulin ligands and cytokines differentially affect proliferation and antibody production by human CD5+ and CD5− B lymphocytes

1990 ◽  
Vol 2 (7) ◽  
pp. 603-614 ◽  
Author(s):  
Yasushi Nawata ◽  
Alan M. Stall ◽  
Leonore A. Herzenberg ◽  
Elsie M. Eugui ◽  
Anthony C. Allison
Keyword(s):  
B Lymphocytes ◽  
Antibody Production ◽  
Surface Immunoglobulin

Surface immunoglobulin isotype, activation, and tolerance susceptibility of B lymphocytes of New Zealand black mice

1981 ◽  
Vol 63 (2) ◽  
pp. 385-399 ◽  
Author(s):  
B.L. Pike ◽  
J.E. Layton ◽  
N.R. Rose ◽  
G.J.V. Nossal
Keyword(s):  
New Zealand ◽  
B Lymphocytes ◽  
Immunoglobulin Isotype ◽  
Surface Immunoglobulin

Visualization of surface immunoglobulin of human B lymphocytes using microsphere—Immunoglobulin conjugate in Giemsa-stained preparations

1977 ◽  
Vol 8 (1) ◽  
pp. 51-63 ◽  
Author(s):  
I.L. Gordon ◽  
R.J. Lukes ◽  
R.L. O'Brien ◽  
J.W. Parker ◽  
A. Rembaum ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Surface Immunoglobulin

scholarly journals Spurious E rosette formation in B cell chronic lymphocytic leukemia due to monoclonal anti-sheep RBC antibody

Blood ◽  
1985 ◽  
Vol 65 (2) ◽  
pp. 270-274 ◽  
Author(s):  
LE Mills ◽  
JF O'Donnell ◽  
PM Guyre ◽  
PJ LeMarbre ◽  
JD Miller ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
B Lymphocytes ◽  
Lymphocytic Leukemia ◽  
Rosette Formation ◽  
Surface Markers ◽  
Simultaneous Presence ◽  
Surface Immunoglobulin ◽  
Monospecific Antisera ◽  
Cell Chronic Lymphocytic Leukemia

Abstract The apparent simultaneous presence of surface markers characteristic of both B and T cells is a phenomenon being described with increasing frequency in patients with chronic lymphocytic leukemia (CLL). We describe a patient with CLL whose B lymphocytes possessed surface immunoglobulin reactive with neuraminidase-treated sheep erythrocytes (SRBCs) and produced E rosette formation. Cytofluorography using monoclonal antibodies demonstrated the B cell nature of these cells and the absence of the SRBC receptor. Further documentation that the binding of SRBCs was mediated through immunologic reaction included E rosette formation inhibition by monospecific antisera and hemagglutination of SRBCs by a paraprotein isolated from the patient's serum. Fusion of the CLL cells with a human hypoxanthine-aminopterin- thymidine-sensitive plasma cell line resulted in the production of human hybridomas that secreted the SRBC-reactive IgM antibody. An analysis of clinical histories of CLL patients whose cells exhibited this phenomenon from both immunologic and clinical perspectives is presented.

Generation of phosphatidic acid and diacylglycerols following ligation of surface immunoglobulin in human B lymphocytes: Potential role in PKC activation

1992 ◽  
Vol 141 (2) ◽  
pp. 373-387 ◽  
Author(s):  
Mary A. Valentine ◽  
Stuart L. Bursten ◽  
Ward E. Harris ◽  
Kevin E. Draves ◽  
Brian A. Pollok ◽  
...  
Keyword(s):  
Phosphatidic Acid ◽  
B Lymphocytes ◽  
Potential Role ◽  
Surface Immunoglobulin ◽  
Pkc Activation

Surface Immunoglobulin D as a Functional Receptor for a Subclass of B Lymphocytes

1977 ◽  
Vol 37 (1) ◽  
pp. 89-104 ◽  
Author(s):  
Donald E. Mosier ◽  
Ian M. Zitron ◽  
James J. Mond ◽  
Aftab Ahmed ◽  
Irwin Scher ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Surface Immunoglobulin ◽  
Immunoglobulin D ◽  
Functional Receptor

scholarly journals the relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. III. Expression of a single predominant isotype on primed and unprimed B cells

1978 ◽  
Vol 147 (5) ◽  
pp. 1374-1394 ◽  
Author(s):  
I Zan-Bar ◽  
ES Vitetta ◽  
F Assisi ◽  
S Strober
Keyword(s):  
B Cells ◽  
Bovine Serum Albumin ◽  
Antibody Response ◽  
B Lymphocytes ◽  
Primary Response ◽  
Spleen Cells ◽  
Cell Sorter ◽  
Immunoglobulin Isotype ◽  
Surface Immunoglobulin ◽  
The Relationship

We determined whether primed and unprimed B cells in the spleen of (BALB/c × C57BL/Ka)F(1) mice contain subpopulations that express a predominant surface Ig isotype. Spleen cells were stained for surface isotypes and sorted on the fluorescence-activated cell sorter (FACS) in order to obtain B cells bearing predominantly IgM (μp cells), IgD (δp cells), or IgG (γp cells). Each population was assayed for its capacity to restore the adoptive primary and secondary anti-bovine serum albumin (BSA) antibody response in irradiated syngeneic recipients. In addition, the adoptive response restored by isotype-predominant cells was compared to that restored by isotype- positive cells (B cells bearing a given surface isotype alone or in combination with others). The experimental results show that μp cells restore the adoptive primary and secondary IgM and IgG responses to BSA, and γP cells restore only the primary and secondary IgG response. Δp Cells restored the adoptive secondary IgG response, but failed to restore the adoptive primary response at the cell doses tested. ΓP Cells but not δp cells suppressed the IgM response of the μ(+) and δ(+) cells. The contribution of isotype-predominant cells to both the adoptive primary and secondary anti-BSA response was smaller than that of B cells bearing a combination of surface isotypes. Differences in the Ig isotype pattern expressed on the surface of primed and unprimed B cells are discussed.

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