scholarly journals Subcellular localization and translocation of protein kinase C isoforms zeta and epsilon in human peripheral blood lymphocytes

1997 ◽  
Vol 9 (10) ◽  
pp. 1431-1439 ◽  
Author(s):  
C Keenan
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Subcellular Localization ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes ◽  
Kinase C ◽  
Protein Kinase C Isoforms

Cyclosporine inhibits protein kinase C-dependent signals in human peripheral blood lymphocytes

1989 ◽  
Vol 46 (4) ◽  
pp. 292-295 ◽  
Author(s):  
Marvin A. McMillen ◽  
Harold A. Schaefer ◽  
John D. MacArthur ◽  
Thomas A. Adrian ◽  
Irvin M. Modlin
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes ◽  
Kinase C

scholarly journals Regularities of endogenous lipid metabolites formation in phorbol 12-miristate 13-acetate-stimulated peripheral blood lymphocytes at leukemia

2011 ◽  
Vol 57 (4) ◽  
pp. 420-428
Author(s):  
T.B. Batikyan ◽  
G.V. Hakopyan ◽  
M.P. Lazyan ◽  
T.P. Torgomyan ◽  
R.A. Kazaryan ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Palmitic Acid ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Biologically Active ◽  
Leukemic Cells ◽  
Blood Lymphocytes ◽  
Kinase C ◽  
Lipid Metabolites

Regularities of biologically active lipid metabolites formation in dynamics (5, 10, 30, 60 s) by phorbol 12-miristate 13-acetate stimulation in [14C]palmitic acid have been investigated in normal and leukemia peripheral blood lymphocytes prelabeled with [14C]palmitate. In normal cells there was two-phase formation of 1,2-diacylglycerol (5, 30 s), lysophosphatidylcholine (10, 60 s), as well as free palmitic acid at 10 s of stimulation. Under the identical experimental conditions there was inhibition of investigated lipid release processes at early (5 and 10 s) stages of stimulation of leukemic lymphocytes. At later (30, 60 s) terms of these lymphocytes the activation, basically, similar to norm changes in the formation of palmitic acid-containing metabolites except free palmitic acid (the level of which raised only at 60 second of the post-stimulation) was found. Various protein kinases C are involved in the regulation of investigated lipid levels at certain stages of signal transduction both in norm, and in blast cells. Short-term (5, 10 s) activations of healthy donors lymphocytes are coupled to functioning of Са2+-independent isoforms of protein kinase C. The inhibition of this protein kinase C in leukemic cells leads to normalization of the investigated lipid release. The data obtained suggests disorders of early membrane-bound reactions in agonist - and a protein kinase C-mediated processes of formation palmitic acid-containing lipid metabolites in the leukemic cells in comparison with the norm.

Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization

2016 ◽  
Vol 300 ◽  
pp. 18-25 ◽  
Author(s):  
Sabrina Sayori Okada ◽  
Edson Mendes de Oliveira ◽  
Tomaz Henrique de Araújo ◽  
Maria Rita Rodrigues ◽  
Renata Chaves Albuquerque ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Human Peripheral Blood Lymphocytes
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