scholarly journals Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

2015 ◽  
Author(s):  
L. Foquet ◽  
C. C. Hermsen ◽  
L. Verhoye ◽  
G.-J. van Gemert ◽  
R. Cortese ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Mouse Model ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Liver Infection

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

2018 ◽  
Vol 61 (13) ◽  
pp. 5692-5703 ◽  
Author(s):  
Nishanth Kandepedu ◽  
Diego Gonzàlez Cabrera ◽  
Srinivas Eedubilli ◽  
Dale Taylor ◽  
Christel Brunschwig ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Mouse Model ◽  
Kinase Inhibitors ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
In Vivo Efficacy ◽  
Phosphatidylinositol 4

scholarly journals Plasmodium falciparum genetic crosses in a humanized mouse model

2015 ◽  
Vol 12 (7) ◽  
pp. 631-633 ◽  
Author(s):  
Ashley M Vaughan ◽  
Richard S Pinapati ◽  
Ian H Cheeseman ◽  
Nelly Camargo ◽  
Matthew Fishbaugher ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Mouse Model ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Genetic Crosses

scholarly journals A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugs

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yoann Duffier ◽  
Audrey Lorthiois ◽  
Pau Cisteró ◽  
Florian Dupuy ◽  
Grégory Jouvion ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Mouse Model ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
In Vivo Evaluation ◽  
Sexual Stages

scholarly journals Preclinical platform for long-term evaluation of immuno-oncology drugs using hCD34+ humanized mouse model

2020 ◽  
Vol 8 (2) ◽  
pp. e001513
Author(s):  
Nahee Park ◽  
Kamal Pandey ◽  
Sei Kyung Chang ◽  
Ah-Young Kwon ◽  
Young Bin Cho ◽  
...  
Keyword(s):  
Mouse Model ◽  
Humanized Mice ◽  
Preclinical Models ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Durable Response ◽  
Term Efficacy ◽  
Nsg Mice ◽  
Oncology Research

BackgroundWell-characterized preclinical models are essential for immune-oncology research. We investigated the feasibility of our humanized mouse model for evaluating the long-term efficacy of immunotherapy and biomarkers.MethodsHumanized mice were generated by injecting human fetal cord blood-derived CD34+ hematopoietic stem cells to NOD-scid IL2rγnull (NSG) mice myeloablated with irradiation or busulfan. The humanization success was defined as a 25% or higher ratio of human CD45+ cells to mice peripheral blood mononuclear cells.ResultsBusulfan was ultimately selected as the appropriate myeloablative method because it provided a higher success rate of humanization (approximately 80%) and longer survival time (45 weeks). We proved the development of functional T cells by demonstrating the anticancer effect of the programmed cell death-1 (PD-1) inhibitor in our humanized mice but not in non-humanized NSG mice. After confirming the long-lasting humanization state (45 weeks), we further investigated the response durability of the PD-1 inhibitor and biomarkers in our humanized mice. Early increase in serum tumor necrosis factor α levels, late increase in serum interleukin 6 levels and increase in tumor-infiltrating CD8+ T lymphocytes correlated more with a durable response over 60 days than with a non-durable response.ConclusionsOur CD34+ humanized mouse model is the first in vivo platform for testing the long-term efficacy of anticancer immunotherapies and biomarkers, given that none of the preclinical models has ever been evaluated for such a long duration.

scholarly journals LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes

2015 ◽  
Vol 39 (6) ◽  
pp. 649-656 ◽  
Author(s):  
Kristina M. DiFranco ◽  
Nadine Johnson-Farley ◽  
Joseph R. Bertino ◽  
David Elson ◽  
Brian A. Vega ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tumor Regression ◽  
Caspase 8 ◽  
Humanized Mouse ◽  
Humanized Mouse Model
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