Extraction and Spectrophotometry Determination of Benzthiazide, Hydrochlorothiazide, and Hydroflumethiazide in Pharmaceuticals

1970 ◽  
Vol 53 (3) ◽  
pp. 582-584
Author(s):  
F Raymond Fazzari
Keyword(s):  
Acetic Acid ◽  
Spectrophotometric Determination ◽  
Organic Phase ◽  
Active Ingredient ◽  
Separation Techniques

Abstract A method has been developed for the determination of benzthiazide, hydrochlorothiazide, and hydroflumethiazide in pharmaceuticals. The procedure is rapid and specific and employs established separation techniques. The active ingredient is eluted from a basic Celite column with an acetic acid-ether solvent and extracted from the organic phase into NaOH for the spectrophotometric determination.

Collaborative Study of a Column Chromatographic Method for Chlorothiazide, Methyclothiazide, and Polythiazide

1973 ◽  
Vol 56 (3) ◽  
pp. 677-680
Author(s):  
F Raymond Fazzari
Keyword(s):  
Acetic Acid ◽  
Spectrophotometric Determination ◽  
Organic Phase ◽  
Chromatographic Method ◽  
Collaborative Study ◽  
Standard Deviations ◽  
Column Chromatographic

Abstract Chlorothiazide is eluted from a K2HPO4 column with acetic acid-ether solvent and extracted from the organic phase into HCl for the Spectrophotometric determination. Methyclothiazide and polythiazide are eluted from a NaHCO3 column with CHCl3 and measured directly. The method was collaboratively studied by 10 analysts. The average per cent recovered and standard deviations for preparations of chlorothiazide and methyclothiazide were 100.2±0.67 and 99.8±1.64, respectively. The method for chlorothiazide and methyclothiazide has been adopted as official first action.

Spectrophotometric determination of bismuth with diethylenetriaminepenta-acetic acid

Talanta ◽  
1978 ◽  
Vol 25 (11-12) ◽  
pp. 691-692 ◽  
Author(s):  
P. Nenova ◽  
D. Kantcheva ◽  
B. Karadakov
Keyword(s):  
Acetic Acid ◽  
Spectrophotometric Determination

TLC Separation and Spectrophotometric Determination of 2-Aminoanthraquinone in D&C Blue No. 9

1969 ◽  
Vol 52 (4) ◽  
pp. 831-832
Author(s):  
Sandra J Bell
Keyword(s):  
Acetic Acid ◽  
Thin Layer ◽  
Spectrophotometric Determination ◽  
Diethyl Ether ◽  
Thin Layer Plate ◽  
Color Additive ◽  
Tlc Separation

Abstract Batches of 3,3’-dichloroindanthrene meeting the specifications set forth in the Color Additive Regulations are certifiable as D&C Blue No. 9. One of the specifications requires that D&C Blue No. 9 contain no more than 0.2% 2-aminoanthraquinone. In the method described, 2-aminoanthraquinone is extracted from D&C Blue No. 9 with dimethylsulfoxide, together with several other impurities. This solution is spotted onto a thin layer plate and developed with diethyl ether. After removal from t he plate, the 2-aminoanthraquinone is extracted into acetic acid and the amount is determined spectrophotometrically. Recoveries of 0.1, 0.2, and 0.5% of added intermediate ranged from 86 to 96%.

Spectrophotometric determination of acetone in acetic acid

1983 ◽  
Vol 28 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Wadala A. Bashir ◽  
Ghazar W. Hagop ◽  
S. Flamerz
Keyword(s):  
Acetic Acid ◽  
Spectrophotometric Determination
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