Gradient Liquid Chromatographic Method for Determination of Chlorhexidine and Its Degradation Products in Bulk Material
1996 ◽
Vol 79
(3)
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pp. 636-639
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Keyword(s):
Abstract A liquid chromatographic method was developed for determination of chlorhexidine and its degradation products in unformulated drug substance. A nonlinear gradient from 80% 0.1 M ammonium acetate buffer, pH 5.0, to 20% buffer over 90 min (balance is acetonitrile) is applied to a 3 μm octadecylsilane bonded-phase column. The drug and some of its degradation products are determined at 230 nm. Of 11 previously identified degradation products, 9 are determined with good precision (relative standard deviation of peak area is <2%).
2004 ◽
Vol 87
(5)
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pp. 1093-1097
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2015 ◽
Vol 05
(51)
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pp. 13-20
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2020 ◽
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pp. 1037-1051
2010 ◽
Vol 72
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pp. 401
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2009 ◽
Vol 92
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pp. 404-409
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2004 ◽
Vol 87
(4)
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pp. 842-846
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1985 ◽
Vol 318
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pp. 144-148
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1992 ◽
Vol 75
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pp. 379-383
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1991 ◽
Vol 74
(3)
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pp. 487-493
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